The 10 Best Anti-Aging Serums That Gave Testers Botox-Level Results

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The 10 Best Anti-Aging Serums That Gave Testers Botox-Level Results

Target dark spots, fine lines, dullness, and more.

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In This Article

  • Top Picks
  • Reviews
  • What to Look For
  • How We Tested
  • Frequently Asked Questions
  • Meet Our Experts
  • Why Trust Byrdie
Two women applying anti-aging serums to their faceTwo women applying anti-aging serums to their face

Byrdie

TL;DR

Our top pick, Estée Lauder Advanced Night Repair, won us over with its silky texture, rapid absorption, and potent blend of hyaluronic acid and peptides that left our skin plumper and smoother overnight. If you want a retinol that really works without the steep price tag, La Roche-Posay’s Retinol B3 Serum is gentle yet effective for improving texture, tone, and firmness.

When I turned 40 at the end of last year, I started analyzing my face with even more scrutiny. After over a decade working as a beauty editor and writer, I’ve been schooled on how to take meticulous care of my skin—and have been proactive about it for years (sunscreen, always; vitamin C, acids, all the things). Still, I notice gradual changes in my skin texture and tone that have me reaching for the most potent formulas to help slow the clock. We can embrace the beauty and privilege of aging while also not loving all of the physical changes that come with it.

If you’d also like to soften the signs of aging, there are noninvasive products that can help. Hardworking, “active” face serums are a great place to start. “Anti-aging serums have been proven to help reduce the signs of agingby lessening fine lines and wrinkles, fading sunspots, and tightening sagging skin,” says board-certified plastic surgeon Dr. Sheila Malek Kassir, M.D. She explains that the results will vary depending on how significant your signs of aging are, how your skin reacts to the product, and how consistently you use it. “So, while anti-aging serums can be game changers, it’s all about finding the right fit for you and sticking with it.”

To find the best anti-aging serums on the market, we enlisted the help of some of our testers with varying age-related skin concerns (including me) to try out dozens of popular and highly rated formulas. Over eight weeks (in several rounds), our editors and testers of various ages, skin types, and skin concerns evaluated each serum. We considered the ingredients, consistency, absorption, effectiveness, and overall results (we even paid attention to packaging). And then we carefully checked our skin to see if the products smoothed fine lines, softened texture, and made our skin feel more hydrated. Here, we’re sharing which ones impressed us the most.

Top Picks

Best Overall:

Estée Lauder Estée Lauder Advanced Night Repair at Amazon$128

Jump to Review

Best Budget-Friendly:

The Ordinary GF 15% Serum for Visible Skin Repair and Wrinkles at Amazon$16

Jump to Review

Best Firming:

Caudalie Premier Cru Anti-Aging Serum at Amazon$129

Jump to Review

Best Brightening:

Environ Vita-Peptide C-Quence Serum 1 at Joannaczech.com

Jump to Review

Best for Fine Lines:

Lancôme Advanced Génifique Youth Activating Concentrate at Amazon$89

Jump to Review

Best Drugstore:
SALE

No7 Protect & Perfect Serum at Amazon$28$19

Jump to Review

Best Plumping:
SALE

Sulwhasoo Concentrated Ginseng Rejuvenating Serum at Amazon$215$174

Jump to Review

Best With Retinol:

La Roche-Posay Retinol B3 Retinol Serum at Amazon$45

Jump to Review

Best Hydrating:
SALE

Clarins Double Serum Firming at Amazon$140$114

Jump to Review

Best for Rapid Results:

Murad Retinal ReSculpt Overnight Treatment at Amazon$105

Jump to Review


Best Overall

Estée Lauder Estée Lauder Advanced Night Repair

Estee Lauder Advanced Night RepairEstee Lauder Advanced Night Repair
Credit: Amazon
$128 at Amazon

$85

$81 at Amazon$85 at Sephora

What We Like
  • Layers nicely with other skincare products

  • Helps smooth the appearance of fine lines

  • Makes skin feel soft and plump

  • Chic bottle with ideal dropper

What to Consider
  • Need to use consistently to see results

  • Short shelf-life after opening

Key Ingredients: Hyaluronic acid, peptide| Dosage: A few drops twice daily| Cruelty-Free: No

Certain products stand the test of time, and this iconic, deeply hydrating overnight serum is one of them. Out of all of the products we tested, it secured the top spot thanks to its ideal texture and potent ingredients. We’re talking water-loving hyaluronic acid, antioxidants, and the brand’s patent peptides. Peptides are a hero ingredient that smooths fine lines and improves collagen production.

Our tester, who has combination skin that’s also sensitive, was looking to combat seasonal dryness and a loss of firmness. He raved about the serum’s silky texture and how quickly it absorbs: It’s like my skin is drinking water,” he shared, adding that results were noticeable right away. He experienced firmer, brighter, and plumper skin. It glides on effortlessly, doesn’t pill, and layers seamlessly with other products (even retinol; though always check with your dermatologist if you have any concerns). Bonus points for the chic, dark glass bottle that looks great on your vanity and a dropper that dispenses just the right amount every time.

Site Loop: Person’s face before and after using x Estee Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum product.

Alfredo, tester age 40-44: “I used this product consistently without fail, and I noticed a difference in my skin firmness, brightness, plumpness, and hydration. I also got compliments—some assumed that I had retouched my Botox (which I hadn’t!).”


Best Budget-Friendly

The Ordinary GF 15% Serum for Visible Skin Repair and Wrinkles

The Ordinary GF 15% Serum for Visible Skin Repair and WrinklesThe Ordinary GF 15% Serum for Visible Skin Repair and Wrinkles
Credit: The Ordinary
$16 at Amazon$16 at Sephora$16 at Ulta
What We Like
  • Very affordable price

  • Smooths appearance of fine lines

  • Layers well with other skincare products

What to Consider
  • Texture is more lotion-like than a standard serum

Key Ingredients: Three different growth factors (EGF, IGF, and TGF)| Dosage: A few drops twice daily | Cruelty-Free: Yes

If you’re looking for an anti-aging serum at a super reasonable price point, I highly recommend this option from The Ordinary. Formulated with three different growth factor ingredients, it’s meant to help the skin regenerate and improve the visible signs of aging. Trust me, it does. After just 10 days, I noticed an improvement in fine lines on my forehead.

I was taken aback by the lightweight, lotion-like texture at first, but ended up appreciating it since it layered beautifully in my skincare routine without pilling or feeling too heavy. My skin felt smoother overall with consistent use.

before and after of a person using The Ordinary GF serumbefore and after of a person using The Ordinary GF serum

Byrdie


Best Firming

Caudalie Premier Cru Anti-Aging Serum

Caudalie Premier Cru Anti-Aging Serum with Niacinamide and Hyaluronic AcidCaudalie Premier Cru Anti-Aging Serum with Niacinamide and Hyaluronic Acid
Credit: Caudalie

$129

$123 at Amazon$129 at Sephora$129 at Nordstrom

What We Like
  • Great for skin tightening

  • A little goes a long way

  • Feels refreshing and smoothing on skin

  • Layers well with other products

What to Consider
  • May not be ideal for sensitive skin

  • Has a mild fragrance

Key Ingredients: niacinamide, hyaluronic acid, grapeseed extract | Dosage: 1-2 drops morning and evening| Cruelty-Free: no

If “French-girl skin” is your vibe, this Caudalie serum delivers it in a bottle. It’s packed with a high concentration of hyaluronic acid, an instant skin-plumper, and niacinamide, which is known for its calming and texture-improving properties. Add on antioxidants, such as grapeseed extract, and you’re on your way to that coveted Parisian radiance.

What our tester, who has “normal,” smooth skin and a penchant for “clean beauty,” loved most about it are the skin-tightening and hydrating benefits. We’re talking an instant face lift in a bottle. She noted the texture having a little weight to it, which felt nice as it penetrated deeply into the skin. It’s easy to layer under makeup and skincare, making it an excellent morning pick. It did, however, cause itching on her jawline, so for anyone with sensitive skin, it may be too potent.

Site Loop: Person’s face before and after using x Caudalie Premier Cru Anti-Aging Serum with Niacinamide and Hyaluronic Acid product.

Rachel, tester age 40-44: “My skin felt refreshed and a bit pulled back (in the best way!) after using the serum. It was like having a protective seal on the face.”


Best Brightening

Environ Vita-Peptide C-Quence Serum 1

Environ Vita-Peptide C-Quence Serum 1Environ Vita-Peptide C-Quence Serum 1
Credit: Environ
View on Joannaczech.com
What We Like
  • Brightens and evens skin tone

  • Milky, hydrating texture

  • Plays well with other products

What to Consider
  • Packaging feels a bit medicinal

Key Ingredients: vitamins C, E, and A, peptides, antioxidants (green tea extract, rosemary leaf extract), sodium hyaluronate| Dosage: A few pumps morning and evening| Cruelty-Free: yes

Vitamin C serums are often sticky and smelly, which is why this milky, scent-free formula is such a standout. Blessed by celebrity esthetician Joanna Czech, the serum offers potent vitamin A to skin while being suitable for more sensitive skin types. Expect it to tackle everything from tightening the look of pores to fading hyperpigmentation and smoothing fine lines over time. Keep in mind: daily SPF is a must, since this potent serum can increase sun sensitivity.

When I tested this product, I appreciated how well it worked for my combination skin, which tends to be sensitive. I loved the hydrating, skin-brightening results so much that I’m using this serum to the very last drop (and would gladly repurchase it). Elements I appreciated most: the light, milky texture that melted into skin, how it sits smoothly under makeup, and that it absorbs instantly. If I could change one thing, I would put it in prettier packaging and create a travel-size offering.

Site Loop: Person’s face face before and after using x Environ Vita-Peptide C-Quence Serum product.


Best for Fine Lines

Lancôme Advanced Génifique Youth Activating Concentrate

Lancôme Advanced Génifique Youth Activating ConcentrateLancôme Advanced Génifique Youth Activating Concentrate
Credit: Ulta Beauty

$89

$85 at Amazon$220 at Sephora$220 at Nordstrom

What We Like
  • Tackles 10 anti-aging concerns

  • Layers nicely with other skincare products

  • Hydrates and softens skin

What to Consider
  • It could work better in a pump bottle

Key Ingredients: Bifidusprebiotic, hyaluronic acid, vitamin C| Dosage: A few drops morning and night | Cruelty-Free: No

This is another iconic serum that’s been around the block for some time. Since the aughts, this formula has been helping people tackle the “10 signs of aging,” including everything from lack of radiance and fine lines to uneven skin texture and tones. Even though it’s considered tried and true, we had to test it ourselves, of course.

What our reviewer, whose combination skin tends to lean dry, discovered is that it’s still a high-quality formula that feels light, absorbs evenly, and offers significant hydration. She noticed line-smoothing results on her neck, even though it’s not marketed as a décolleté product. On her wish list? A pump bottle instead of a dropper since it’s such a watery consistency.

Site Loop: Person’s face before and after using x Lancôme Advanced Génifique Youth Activating Concentrate product.

Ashley, tester age 35-39: “I noticed a big change [in fine lines] on my neck. The serum isn’t specifically for the neck, but I applied it there anyway and am happy with the results.”


Best Drugstore

No7 Protect & Perfect Serum

No7 Protect & Perfect Intense Advanced SerumNo7 Protect & Perfect Intense Advanced Serum
Credit: Ulta beauty

$28

$19 at Amazon

$35

$21 at Ulta$28 at Target

What We Like
  • Powder-like finish

  • Actually minimizes fine lines

  • Super hydrating

  • Brightens complexions

What to Consider
  • May need to build tolerance for sensitive skin

Key Ingredients: peptide duo, vitamin A (pro-retinol), hyaluronic acid, vitamin C, Salicylic Acid, hydrolyzed rice protein, botanical extracts (alfalfa, mulberry ginseng)| Dosage: 1-2 pumps once a day| Cruelty-Free: Yes

It’s rare to find a product—especially a drugstore gem—that our tester wouldn’t tweak in some way, so when we do, we stock up. That was exactly the case with this No. 7 serum. It’s packed with a potent medley of skin-loving ingredients: collagen-stimulating peptides, cell-renewing retinol, antioxidant vitamins C and E, hydrating hyaluronic acid, and botanical boosters. For under $30, this anti-aging blend won our tester’s heart and noticeably improved her skin.

Though she often struggles with redness (on her forehead, chin, and around her nose) and age-related fine lines, this lightweight serum absorbed beautifully and helped blur away imperfections, even the stubborn wrinkles around her mouth. One standout feature is its ultra-hydrating yet featherweight texture: it glides on smoothly and dries down to a soft, powder-like finish. Bonus points for being odorless, non-pilling, and flake-free. Just note it’s pretty potent, so those with sensitive skin may want to slowly build up a tolerance.

Site Loop: Person’s face before and after using x No. 7 Protect & Perfect Intense Advanced Serum product.

Heidi, tester age 50-59: “Overall, the serum made my skin softer, more hydrated, and brighter with softened lines around my mouth.”


Best Plumping

Sulwhasoo Concentrated Ginseng Rejuvenating Serum

Sephora Sulwhasoo Concentrated Ginseng Rejuvenating Serum for Anti-AgingSephora Sulwhasoo Concentrated Ginseng Rejuvenating Serum for Anti-Aging
Credit: Sephora

$215

$174 at Amazon$215 at Sephora$135 at Nordstrom

What We Like
  • Super skin plumping

  • Quick and easy application

  • Helps instantly smooth skin

What to Consider
  • Has a subtle ginseng scent

  • Bulky bottle

Key Ingredients: ginseng actives, peptides, and retinol capsules plus hyaluronic acid, niacinamide, vitamin E, and cocoa extract| Dosage: 2-3 pumps warmed up in hands, twice a day| Cruelty-Free: No

If you like your skincare fast and effective, this skin-plumping serum delivers. Our tester, who has combination and sensitive skin, noted that it feels weightless and sinks in within about 30 seconds. So if you’re rushing in the morning (hi, fellow moms), rest assured, it absorbs quickly and layers well under other products. It does have a slightly herbal, floral scent, but that fades fast, too.

While the bottle is hefty with an oversized cap, you can easily see how much product you have left (always helpful), and the pump dispenses just the right amount for your face and neck. With consistent use, expect skin that feels fresher, bouncier, and deeply nourished.

Site Loop: Person’s face before and after using x Sulwhasoo Concentrated Ginseng Rejuvenating Serum for Anti-Aging product.

Ally Hirschlag, associate editorial director, age 40-44: “The improvements I’ve noticed are subtle, but upon looking at my before and after, I can see smoother, brighter, plumper-looking skin that generally seems more hydrated.”


Best With Retinol

La Roche-Posay Retinol B3 Retinol Serum

La Roche-Posay Retinol Face Serum with Vitamin B3La Roche-Posay Retinol Face Serum with Vitamin B3
Credit: Amazon
$45 at AmazonView on UltaView on Dermstore
What We Like
  • Improves uneven skin texture

  • Increases skin firmness

  • Lightweight and fast-absorbing

What to Consider
  • Could be better at addressing fine lines

Key Ingredients: Pure retinol, niacinamide, hyaluronic acid| Dosage: 3-4 drops nightly | Cruelty-Free: No

Finding an over-the-counter retinol that truly works is no easy feat, so discovering one at a drugstore price makes it even better. This pick from French pharmacy favorite La Roche-Posay is an excellent choice for a retinol serum that truly transforms the skin. It combines pure retinol, niacinamide, and hyaluronic acid to boost cell turnover, smooth uneven texture and tone, and keep the skin barrier healthy and hydrated.

The formula is lightweight, fast-absorbing, and layers beautifully with the rest of your routine. After eight weeks of nightly use, our tester saw firmer, clearer skin with a noticeably smoother feel and fewer blemishes and dark spots. While fine lines didn’t change dramatically in that time, we’re confident longer use would reveal even more results, especially given the gentle, well-balanced formula. Considering that it’s suitable for all skin types and relatively affordable compared to similar options, we can’t recommend it enough.

A person before, during, and after applying the La Roche-Posay Retinol B3 Pure Retinol SerumA person before, during, and after applying the La Roche-Posay Retinol B3 Pure Retinol Serum

Byrdie

Lauren Pardee, senior editor with dry skin, age 25-32: “What sets this serum apart is how gentle it feels (for retinol!) when using an appropriate amount. It doesn’t dry my skin out to an insane degree like others can. After a few weeks of use, I noticed that it improved my skin texture and gave me a glowy complexion.”


Best Hydrating

Clarins Double Serum Firming

Clarins Double SerumClarins Double Serum
Credit: Sephora

$140

$114 at AmazonView on Sephora$95 at Ulta

What We Like
  • Rich texture feels hydrating

  • Makes skin look plump and dewy

  • Great for incorporating into nighttime skincare routine

What to Consider
  • Has a strong floral fragrance

Key Ingredients: Turmeric, Harungana extract, peptides| Dosage: A few drops 1-2 times daily| Cruelty-Free: No

According to Dr. Kassir, our skin loses elasticity and buoyancy as we age (starting in our 20s), so if you’re looking for an anti-aging serum to give your skin a softer, more plump appearance and hydrated feel, it’s important to find something that supports elasticity. This popular one from Clarins is great because it’s packed with peptides known to help plump and nourish the skin. The texture is rich and a bit oily, making it a hydrating formula that I preferred to use at night. I loved how it added a moisturizing layer to my winter skincare routine. It’s worth noting that if you prefer a lighter serum, it comes in a more lightweight version (I used this for daytime!).

After using it at night consistently, I woke up with dewier skin. While I didn’t see any major changes in dark spots or fine lines, I still recommend it if you’re looking for a plumping serum that offers a healthy dose of hydration.

A person before and after using Clarins Double Serum Firming & Smoothing Anti-Aging ConcentrateA person before and after using Clarins Double Serum Firming & Smoothing Anti-Aging Concentrate

Byrdie


Best for Rapid Results

Murad Retinal ReSculpt Overnight Treatment

Ulta Murad Retinal ReSculpt Overnight TreatmentUlta Murad Retinal ReSculpt Overnight Treatment
Credit: Ulta

$105

$95 at Amazon$105 at Sephora$105 at Ulta

What We Like
  • Provides noticeable results in just 10 days

  • Smooths skin

  • Not super drying

What to Consider
  • Might not be ideal for retinol beginners

Key Ingredients: Encapsulated retinal, olive, oat, and alpha glucan| Dosage: Apply a thin layer at night | Cruelty-Free: Yes

Serums are not miracle workers that magically make you look 10 years younger, but if you’re looking for one that provides some noticeable results quickly, this is the one for you. Powered by encapsulated retinol, which is potent yet gentle, it works to smooth fine lines and skin texture and improve firmness. After using it for just 10 days, our tester began to notice visible results. Her skin felt smoother, and she noted that her usually very dark under-eye area looked a bit brighter. She also appreciated the formula’s lotion-like texture that didn’t dry out her skin. Plus, it layered beautifully in her skincare routine without pilling or taking too long to absorb.

This stuff is potent, so if you have sensitive skin or are new to retinol, we recommend slowly incorporating it into your routine or opting for a more gentle formula. But if you’ve been using retinol for a while and you’re looking for a stronger over-the-counter option, this is a great choice.

before and after of a person applying the Murad Retinal ReSculpt Overnight Treatmentbefore and after of a person applying the Murad Retinal ReSculpt Overnight Treatment

Byrdie

Ashley, tester age 35-39: “It’s stronger than what I’m used to, but it wasn’t harsh on my skin and didn’t dry me out. [After 10 days] the results weren’t drastic, but my skin looked smoother, and the horrible dark circles under my eyes looked slightly better.”

What to Look for When Buying Anti-Aging Serums

A good anti-aging serum is also a good multitasker, simultaneously reducing fine lines, sun spots, and sagging skin. To determine which anti-aging serum is right for you, we suggest keeping the following factors in mind.

  • Retinoids: Dr. Kassir and board-certified dermatologist Dr. Teresa Song, M.D., highly recommend looking for serums containing retinoids. “Retinoids stimulate collagen production, promote cell turnover, and improve skin texture. They are the family of products which contain vitamin A—the most powerful ingredient to help us stimulate the production of collagen and elastin in our skin,” says Dr. Kassir. Dr. Song notes that the powerful ingredient can improve pigmentation, skin texture, and clogged pores that contribute to acne.  
  • Peptides: “Peptides are a game changer,” Dr. Kassir says. “These amino acids can help improve skin firmness and elasticity by stimulating collagen production.”
  • Antioxidants: According to Dr. Song, antioxidants like vitamin C, vitamin E, and green tea extracts “can help neutralize free radicals, which contributes to skin aging and damage from UV radiation.”  
  • Hyaluronic Acid: “Hyaluronic acid is another hero must-have in every skin routine,” says Dr. Kassir. “This is a humectant that attracts and retains moisture in the skin, helping to plump and hydrate, reducing the appearance of fine lines and wrinkles.”

How We Tested Anti-Aging Serums

Here is exactly how our team of editors and contributors evaluated more than 30 serums over several eight-week periods to determine our top picks.

  • Consistency: The feel of an anti-aging serum can make or break whether you will use it consistently, so it’s important to pick one you like. We noted which serums were runny or thick, how they felt on our skin, and how much product was needed to cover our whole face. We also observed how well each serum layered under our other skincare products and makeup.
  • Absorption: The time it takes for an anti-aging serum to fully absorb into the skin is another essential factor in determining whether you will use the product consistently—we know you have things to do! As such, we paid attention to how long it took for each serum to sink into our skin, docking points if they felt tacky, tight, or sticky.
  • Effectiveness: While an anti-aging serum will never totally turn back the clock, a visible change is possible over time. To track if each product lived up to its claims, we noted if our skin’s texture looked and felt more plump and supple post-testing.
  • Overall Results: When we saw great results from an anti-aging serum, we said something. We made sure to track general improvements (or setbacks) in our skin when using each serum, as well as whether the formula was irritating in any way.
FAQ
  • When should you start using an anti-aging serum?

    The effects of sun exposure often begin to surface in your 20s and 30s, which is why Dr. Song suggests starting an anti-aging serum during these pivotal decades. Dr. Kassir agrees, noting that collagen production starts decreasing in our 20s. But if you’re already seeing physical signs of aging in your skin, it’s not too late to start using these potent serums. They can absolutely help to reduce the appearance of already present concerns.

  • When should you apply anti-aging serums?

    While many anti-aging serums can be applied morning and night, they’re typically most effective while you get your beauty sleep. “When it comes to using anti-aging serums, it’s best to apply at night after you’ve cleansed and toned your skin, but before you moisturize,” says Dr. Kassir. “This way, those active ingredients can really get to work deep down into your skin overnight.” That said, it’s always best to follow the instructions on the specific serum you’re using.

  • Who shouldn’t use anti-aging serums?

    As is true with all skincare products, not every anti-aging serum is for everyone. If you’re pregnant or breastfeeding, it’s recommended to avoid using products containing retinol. If you have sensitive or dry skin, you should also be careful about using serums with retinol or high concentrations of active ingredients. Instead, be sure to choose something that’s gentle and contains hydrating ingredients. And talk to your healthcare provider about any concerns.

Meet Our Experts

We spoke to experts to discuss important things to consider when purchasing anti-aging serums. Those experts included:

  • Dr. Sheila Malek Kassir, M.D., is a German board-certified plastic surgeon and co-founder of Kassir Plastic Surgery and Inside Beauty Spa.
  • Dr. Teresa Song, M.D., is a New York City-based board-certified dermatologist at Marmur Medical.

Why Trust Byrdie

Lauren Levinson is an experienced beauty editor, writer, and product tester with over 15 years in the industry. She’s tested countless anti-aging serums over the years—including several featured in this roundup—and has a deep knowledge of what really works. Plus, since she turned 40 years old, she’s taking her anti-aging skincare routine extra seriously. Lauren holds a degree in magazine journalism from Syracuse University and has led editorial teams at top brands Popsugar Beauty, Verywell Family, and Allergan Aesthetics.

Edited by
Alyssa Kaplan
Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Bauza E, Oberto G, Berghi A, Dal CF, Domloge N. Collagen-like peptide exhibits a remarkable antiwrinkle effect on the skin when topically applied: in vivo study. Int J Tissue React. 2004;26(3-4):105-11. PMID: 15648443.

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Source URL: https://www.byrdie.com/best-anti-aging-serums-4582774


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