Exosomes

By now, you’ve likely heard the term “exosome” mentioned. Simply put, exosomes are what Engelman calls messenger particles that carry proteins and genetic material to other cells. “In skincare, they are being explored for their potential to support repair processes and boost overall skin health,” she says. “Exosomes used by doctors in clinical settings are typically more concentrated than those in skincare products, and they are often delivered through procedures like microneedling or injections, allowing them to penetrate deeper and work more intensively.” She notes that dermatologists utilize exosomes to accelerate the healing process after specific in-office procedures.

On the other hand, topical exosomes are formulated to sit on the skin’s surface and gradually support its natural repair processes. Engelman says, “They carry key messengers that encourage cells to repair and regenerate, which can lead to smoother texture, improved elasticity, and a more radiant appearance.”

Proponents of exosomes believe they also have a place in haircare routines. Engelman shares that exosomes can help with hair growth by sending signals to the hair follicles to extend their hair growth phase, supporting fuller and healthier strands over time.

Yet, despite the buzz surrounding exosomes, they are not currently FDA-approved, which has sparked some controversy. “While the research is still evolving, exosomes are an exciting innovation that could complement existing approaches to maintaining healthy and resilient skin,” Engelman says.

PDRN

If you’ve been seeing PDRN (polydeoxyribonucleotide) creams and serums all over your For You Page, it’s because the ingredient continues to gain significant attention for its regenerative properties. But, what exactly is PDRN? Kim describes it as fragments of salmon sperm DNA. “It’s widely used in Korea as an injectable and skincare ingredient because PDRN can improve the skin’s elasticity, firmness, and texture, and we can also use it on sensitive skin,” he shares.

Several topical skincare products contain PDRN, such as IOPE PDRN Caffeine Shot Serum, Genabell PDRN Enriched Recovery Balm, Medicube PDRN Pink Collagen Gel Mask, and Biodance PDRN Mask, to help improve the skin’s elasticity and hydration levels while also reducing inflammation. This makes the ingredient a good at-home option for post-procedure recovery after a procedure, such as laser or microneedling.

While PDRN-powered skincare products are gaining popularity right now, Kim says that PDRN in injectable form represents a whole new category. “Rejuran is the OG of PDRN, but this new type of injectable product doesn’t sculpt or contour the face but rather rejuvenates and hydrates the skin without changing the way you look,” he adds.

Miniproteins

2025 is the year of the miniprotein. While similar to peptides, what sets miniproteins apart is their formulation and mode of action. Garshick describes miniproteins as short chains of amino acids that serve as signaling molecules. “They instruct the skin to carry out specific functions like collagen production, hydration, or healing,” she says.

Because mini proteins are slightly longer, Garshick says they can fold into more defined three-dimensional shapes, which may allow for greater specificity and more targeted results when binding specific receptors. Another benefit of these small but mighty proteins is that when paired with active ingredients that stimulate collagen within the skin (such as vitamin C, retinol, peptides, and growth factors), they help boost the benefits for an even more dramatic improvement.

Plant-Based Adaptogens

For years, adaptogens such as ashwagandha, holy basil, ginseng, reishi, and rhodiola have held a firm hold in the supplement world, and now, these well-known stress fighters are making their mark on skincare. “These ingredients have been used in traditional medicine for centuries because of their ability to help the body adapt to stress, and now that’s being applied to the skin to combat oxidative stress, soothe inflammation, and support the skin’s natural barrier,” Garshick says.

For the remainder of 2025 and into 2026, expect to see more plant-based adaptogens emerge as key ingredients in every skincare category. “We are going to see plant-based adaptogens in everything from cleansers and serums to moisturizers, oils, masks, and more,” Engelman adds.

NAD

NAD (nicotinamide adenine dinucleotide) is a naturally occurring element found in the body. However, like other essential components of healthy skin, such as peptides and collagen, NAD naturally dips in production and quality with age. With less NAD circulating in the body, the signs of aging become more pronounced.

NAD is one of the more advanced ingredients that can shape the way the skin ages and potentially repair damaged DNA, as it focuses on rebuilding the skin at a cellular level. Although Engelman says NAD is still a relatively new topical skincare ingredient, it’s becoming increasingly prevalent, and there’s some valid science that backs it up. “Studies suggest that NAD can aid in cellular repair, reducing signs of aging and improving barrier function,” she adds. “Right now, there’s interest in functional medicine ingredients in skincare because people are looking for more holistic, root-cause approaches to maintaining healthy skin rather than quick fixes. It’s about treating the skin as an extension of your overall health.”

Ectoin

Ectoin is quickly becoming the must-have ingredient for calming, soothing, and reducing skin stress. According to Garshick, ectoin (sometimes classified as an extremolyte) offers protection from external stressors and helps moisturize the skin while supporting the skin barrier. “It creates a protective shield on the skin that helps support the barrier and prevent water loss,” she says. “By safeguarding against external stressors, it also offers defense against blue light and pollution.”

The antioxidant-rich ingredient is derived from microorganisms and helps them survive in some of the harshest geographical conditions. “In skincare, it helps stabilize cell membranes and maintain hydration, which is key for keeping the skin barrier strong and resilient,” Engelman explains. “It is a wonderful ingredient for dry or compromised skin because it helps the skin hold onto moisture and maintain its natural balance.”

Malassezin

Malassezin is quickly earning a reputation as the next vitamin C, offering greater stability and gentleness for reducing hyperpigmentation, sunspots, dark spots, and various other types of discoloration. “Like vitamin C, it helps to brighten, even out the skin’s tone, and protect against environmental stressors,” Engelman says. “It is also a great alternative to it, especially for sensitive skin types or those who struggle with redness or inflammation.”

The multi-tasking ingredient helps reduce discoloration and fade hyperpigmentation by blocking excess melanin production. Engelman says that this process helps to fade existing dark spots and prevent new ones from forming. “It also has strong antioxidant properties, which help to reduce oxidative stress, a key cause of hyperpigmentation,” she explains. “It can be especially beneficial for those with melasma or post-acne marks.” A good one to try is Mother Science Molecular Hero Serum, which Garshick says is great for dark spots.

Spicules

Spicules, which first gained traction in Korean skincare products, are essentially tiny, needle-like structures derived from sea sponges that help exfoliate the skin and create microchannels to open the pores. The idea of using spicules in skincare is to achieve similar results to microneedling, allowing topically applied skincare ingredients to penetrate the skin at a deeper level and absorb more effectively.

Kim says that spicules can also help improve skin texture and reduce hyperpigmentation, and some studies show that their exfoliating actions can help treat acne. “They don’t replace in-office microneedling treatments, but they can help maintain the results for as long as possible,” he says. His favorite spicule-packed skincare products, which give a prickly sensation when massaged appropriately into the skin, include VT Cosmetics Reedle Shot 50 and the 100 version for those with more sensitive skin.