Whether you’re considering a GLP-1 medication or simply curious about the cost, you’re hardly alone in either camp. With so many virtual health marketplaces advertising “low” monthly prices, it can be difficult to pin down what GLP-1 medications actually cost—with and without insurance.

Ahead, I spoke with two experts to unpack GLP-1 costs, including how pricing works, how insurance factors in and why monthly costs can vary so widely.

Featured Experts

• Eduardo Grunvald, MD is an internist and obesity medicine specialist in San Diego, CA
• Ashley Koff is a registered dietitian and founder of The Better Nutrition Program in Portland, OR

GLP-1 List Prices

List price is essentially the sticker price set by the manufacturer, so what a medication costs before insurance, discounts or savings programs. For GLP-1s, this usually reflects the price of a one-month supply.

There are two important things to know about list prices. First, they’re rarely what people actually pay—even without health insurance—since pharmacy pricing and savings programs can vary widely. Second, list prices aren’t a flat monthly cost across all doses. Instead, they’re tied to specific dose strengths and package sizes defined by the manufacturer.

According to manufacturer list prices, current costs for brand-name GLP-1 medications include:

Ozempic: $1,027.51
Wegovy: $1,349.02
Zepbound: $1,086.37
Mounjuaro: $1,112.16 

Prices and coverage change frequently; these figures reflect manufacturer list pricing available in early 2026.

What GLP-1s Cost With Insurance

There’s no single coverage standard for GLP-1 medications, which is why costs can look very different from one insurance plan to the next. “For commercial insurance, it boils down to the specific policy,” says San Diego internist and obesity medicine specialist Eduardo Grunvald, MD. “This can range from complete plan exclusion to complete coverage. Most of the time, there are restrictions; for example, having a BMI > 40, certain medical conditions or high copays.” Even with insurance approval, the monthly costs for GLP-1s can range from relatively manageable copays to several hundred dollars, depending on the plan’s structure.

That variability isn’t limited to private insurance. “By law, Medicare cannot cover medications for weight loss,” Dr. Grunvald continues. “However, they are covering them for specific conditions as supported by high-quality studies. For example, Zepbound is covered for moderate to severe obstructive sleep apnea; Wegovy is covered for certain heart disease conditions or advanced fatty liver disease. Medicaid programs base their policies on a case-by-case basis, dependent on the individual state.”

What to Do if Your Claim Is Denied

Even when coverage exists, a denial isn’t uncommon, especially at the outset. What to do in this case? “The first step for a patient to consider is to confirm whether it is a plan exclusion or whether prior authorization is required,” says Dr. Grunvald. “It is important for a patient to work closely with their healthcare professional after reviewing the criteria set forth in the denial letter.”

From there, it becomes a question of how clearly that eligibility is documented. “If a patient thinks they qualify based on the documented criteria, their provider should clearly state those reasons in their clinical note for appeal purposes,” Dr. Grunvald explains.

When that process isn’t possible, he notes that seeking specialized care may help. “If the prescriber cannot or will not attempt those steps, the patient can consider seeing a healthcare professional who focuses on weight management. For example, physicians can be certified by the American Board of Obesity Medicine.”

What GLP-1s Cost Without Insurance

For patients paying out of pocket, options—and prices—vary. In some situations, “costs may be even lower” for patients with commercial insurance but no coverage, says Dr. Grunvald. It really “depends on the medication,” he says.

“Eli Lilly has direct-to-consumer pharmacy programs where Zepbound, in vial and syringe form, can be purchased for $300–$450 per month, depending on the dose.” Other branded GLP-1s may fall into a lower range through manufacturer programs. “For injectable Wegovy, it can cost $200–$350 per month from Novo Nordisk’s pharmacy program or with a cost savings card,” he continues.

How the medication is taken also factors in. “For oral Wegovy, with cost savings cards or going through Novo Nordisk’s pharmacy, the price can range from $150–$300 per month, again depending on the dose,” Dr. Grunvald adds.

There are also some lesser-discussed weight-loss medications that may come with very different price points. “Older weight-loss medications such as Qsymia, Contrave and phentermine can be effective, and the cost is usually less than $100 per month,” he says. “Liraglutide (the ingredient in Saxenda, a daily injection) is available in generic form for approximately $200 per month.”

Common Cash-Pay Mistakes

Even with these options, navigating cash-pay pricing (meaning, paying out of pocket without insurance) isn’t always straightforward. Dr. Grunvald says the same missteps tend to come up again and again, including “not confirming that prior authorization is needed for coverage,” “not seeking out obesity medicine-certified professionals if their regular provider does not have the experience to navigate these challenges,” and “not using savings cards for cost savings.” Pharmacies need to be looped in, too. “Confirming their local pharmacy is also aware of the cost-saving options so mistakes are not made in securing the best price.”

Dose, too, can influence monthly costs more than many patients expect. “Some patients do very well at lower doses of drugs,” notes Dr. Grunvald. “One does not always need to be at the maximum dose, which may translate to cash pay savings.”

Paying for GLP-1s via Telehealth

Telehealth platforms (virtual care services that prescribe medications online), have made GLP-1s feel more accessible, often touting low monthly prices and easy sign-ups. But those numbers don’t always reflect the full cost of care.

“There may be a special to ‘get started,’ and just like a radio or TV station trying to get you in, that amount may go up after a month(s),” says registered dietitian Ashley Koff. “You may also have to pay for the medical provider (whether you see them or not) to review your information and write the prescription (or this may be covered but you have to pay for the medication), they may bundle fees with other services (and you may not want or need these), almost none provide the services and products you will need and they may or may not sell to you (personalized nutrition from a qualified clinician, supplements and other medications (how they may impact and what needs to be changed), additional testing, evaluation and adjustments to all aspects of the above ongoing for optimization.”

Evaluating whether a telehealth GLP-1 program is medically appropriate often comes down to understanding what level of support is included—and what may cost extra. “If you are working with a qualified clinical team who is assessing your total nutrition (food and supplements), medications, lifestyle choices and will do so while you are on the medication, you may not need other services, so just getting the medication could be a win.”