{"id":846935,"date":"2025-11-19T14:00:00","date_gmt":"2025-11-19T11:00:00","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=846935"},"modified":"2025-11-19T14:00:00","modified_gmt":"2025-11-19T11:00:00","slug":"what-is-alloclae-before-and-afters","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=846935","title":{"rendered":"What Is Alloclae? | Before and Afters"},"content":{"rendered":"
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FAT CHANCE<\/span><\/span><\/div>\n<\/div>\n<\/div>\n

Would You Get a Fat Transfer With Someone Else’s Fat?<\/h1>\n<\/div>\n
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It\u2019s the newest frontier in regenerative medicine. We asked plastic surgeons for all the details, gory and otherwise.<\/div>\n
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By <\/span>Jolene Edgar<\/span><\/span><\/span><\/div>\n

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Photography by Hannah Khymych<\/span><\/div>\n<\/div>\n<\/figure>\n<\/div>\n<\/div>\n<\/header>\n<\/div>\n
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These days, it\u2019s rare to write about plastic surgery without mentioning fat. We\u2019re either losing it (courtesy of GLP-1s), removing it (via liposuction, the top-ranking surgical procedure last year), reusing it (to plump and contour), or, not uncommonly, doing all three in succession\u2014a sort of carefully orchestrated fat shuffle.<\/p>\n

Now, plastic surgeons are experimenting with a first-of-its-kind body filler derived from\u2014guess what\u2014fat. Donated human fat, to be exact, which has been procured from cadavers and meticulously processed into a thick injectable called Alloclae. Donor tissue\u2014which includes everything from skin and cartilage to ligaments and heart valves\u2014is frequently used in all fields of medicine, including aesthetics, but for some patients, the idea of receiving \u201cfat from a dead person is still a little macabre,\u201d says Troy Pittman, MD, a board-certified plastic surgeon with practices in Washington, DC, and New York City.<\/p>\n

To secure the donor adipose tissue\u2014aka fat\u2014Tiger Aesthetics, the makers of Alloclae, partners with recovery agencies who \u201cwork closely with healthcare providers and family members of donors to review the scope of the deceased individual\u2019s donation,\u201d says a representative for Tiger. Some of you may be morally opposed to (or just totally turned by) the idea of using human parts for cosmetic purposes and will choose to avoid Alloclae just as you might forgo Botox (which contains albumin, a protein in human blood) or exosomes (which are commonly sourced from human cells). But this donated fat can also be considered \u201ca natural alternative [to synthetic fillers and implants],\u201d says Dr. Pittman, explaining that the donor tissues are really acting as a scaffolding for your own fat to grow into. \u201cOnce your body incorporates the graft, the fat is going to be more yours than the donor\u2019s.\u201d<\/p>\n

This isn\u2019t the first time Allure<\/em> has reported on Alloclae. Back in January, before the product officially launched, I included it in a story about the fat-stimulating shot Renuva. Alloclae isn\u2019t a Renuva knockoff, however. It falls into a separate category all its own. What makes it unique and \u201cpotentially groundbreaking,\u201d says Darren Smith, MD, a board-certified plastic surgeon in New York City, is the inclusion of intact, nonliving donor fat cells (and their naturally occurring growth factors), which impart instant volume. Supporting the fat cells in the formula is a proprietary stew of extracellular matrix proteins. These collagens, elastins, and glycoproteins help the donor cells integrate into the body\u2019s own tissue while encouraging innate fat cells and blood vessels to bloom in the area. Renuva, if you recall, is fat cell-free and composed solely of fat-adjacent proteins, which recruit the body\u2019s own fat cells over time.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Designed specifically for the body (the consistency isn\u2019t smooth and fluid enough for the face), Alloclae essentially provides a fat transfer\u2014natural, long-lasting volume\u2014without the hassle, anesthesia, expense, and downtime associated with liposuction. Lipo has forever been a prerequisite for fat grafting\u2014surgeons have to harvest fat from the belly, love handles, thighs, or other areas of excess before processing it and reinjecting it into the body\u2014but it unequivocally adds to the cost and recovery of the procedure and presents its own set of risks, namely contour irregularities (lumps, dents, ripples, and otherwise uneven results). Plus, the thinnest of patients\u2014who are increasing in number with the popularity of GLP-1s\u2014aren\u2019t suitable candidates for liposuction (and therefore fat transfer), since they don\u2019t have much fat to spare. Alloclae not only offers a workaround for these people, but also allows for a non-surgical\u2014and potentially less expensive\u2014fat grafting experience for everyone who might want one. Board-certified plastic surgeon Ashley Gordon, MD, tells me that in her Austin, Texas practice, patients currently pay between $5,000 and $7,000 for 25 ccs of Alloclae, which is enough to \u201cfeather in the cleavage\u201d for a modest boost or to hide the edges of breast implants, which can show through the skin of slender patients. Fat grafting done for the same purpose would cost $10,000 or more, because of the time and anesthesia involved with the lipo.<\/p>\n

The Science and Safety of Alloclae<\/div>\n

\u201cIs it FDA approved?\u201d This is generally the first question we\u2019d urge you to ask about any product you might put in your body. But human tissue-derived materials aren\u2019t vetted in the same way as drugs (like botulinum toxins) and devices (fillers and breast implants). As with Renuva, the FDA regulates Alloclae as a human cell, tissue, and cellular and tissue-based product (HCT\/P), which means that while it must meet certain requirements\u2014related to minimizing the risk of disease transmission as well as contamination during manufacturing, for instance\u2014it doesn\u2019t technically have to be \u201capproved\u201d or \u201ccleared\u201d by the FDA, per the agency\u2019s web site.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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The Center for Biologics Evaluation and Research, a branch of the FDA, governs these materials, ensuring they meet stringent requirements for safety and sterility. Donors must be thoroughly screened and tested to protect against infectious diseases and microorganisms, for example. (Before gifting any tissues, Alloclae donors \u201cgo through an aggressive screening process after they\u2019ve passed away,\u201d explains Sachin M. Shridharani, MD, a board-certified plastic surgeon in New York City and clinical trial investigator for Alloclae.) Additionally, donated tissues must be cleaned and processed in accordance with specific protocols to remove possible contaminants and reduce DNA and other cell components that could provoke an immune reaction or all-out rejection of the fat. \u201cWe know that you need to have less than a certain amount of DNA per volume in order to be safe,\u201d notes Dr. Smith, \u201cAlloclae is well below that established standard.\u201d<\/p>\n

While FDA requirements for tissue-based products are stringent, the FDA doesn\u2019t demand the same caliber of clinical data\u2014meaning long-term studies on large numbers of real people\u2014as it does when evaluating drugs. When Allure reached out to the FDA for comment on the regulation of Alloclae, a representative for the organization stated that, \u201cThe limited information provided on \u2018Alloclae\u2019 is not sufficient for us to determine how \u2018Alloclae\u2019 is appropriately regulated.\u201d<\/p>\n

The published data that currently exists on Alloclae is what\u2019s known as basic science literature\u2014studies involving human cells and mouse models\u2014which essentially shows that the composition of the donor tissue resembles that of native human fat and confirms that any potentially triggering DNA materials have been minimized. The studies also demonstrate that the product does, indeed, integrate into surrounding tissue and promote the growth of new fat cells and blood vessels for a limited time after injection.<\/p>\n

When performing a lower body lift on a woman who\u2019d previously had Alloclae injected in the same area, Kamakshi R. Zeidler, MD, a board-certified plastic surgeon in Campbell, California, had the rare experience of seeing the product in the body, three months after it was placed. (Dr. Zeidler is a clinical study investigator for Alloclae.) The Alloclae appeared to be \u201cvery well accepted [by her tissues] and it was remarkably soft,\u201d she says.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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As for studies involving actual patients, the company says they are \u201cpresently supporting five clinical study sites in the U.S. that are treating approximately 50 patients\u201d and that \u201cthe study is focused on the application of Alloclae in the hips, more specifically when Alloclae is used to improve the appearance of hip dips.\u201d (These are slight indentations that some people have between their hips and thighs.) While the company does not have results to share at this time, they can say that \u201cseveral hundred patients have received Alloclae so far this year in both the hip and breast areas and we have received a lot of positive feedback.\u201d<\/p>\n

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Before (left) and after using Alloclae to correct a \u201chip dip.\u201d Courtesy of Dr. Darren Smith.<\/p>\n

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Some doctors have reservations about injecting Alloclae into the breasts specifically, given its relatively short track record. Steven Teitelbaum, MD, a board-certified plastic surgeon in Santa Monica, doesn\u2019t currently stock Alloclae, but says he would consider using it to camouflage divots on the body if he ever encountered patients with this problem. When it comes to the breasts, however, \u201cI\u2019m just very cautious,\u201d he says. \u201cBefore trying it out on my patients, I\u2019d want to know more about how it does in the breast: How long does it last? What happens when it dissolves? What are the chances of mammographic changes and palpable irregularities? Is there a way to remove it if it doesn\u2019t look right? I don\u2019t think we can definitely answer these basic questions yet.\u201d<\/p>\n

While the uncertainty and lack of human clinical trial data is a sticking point for some, a number of plastic surgeons have adopted the product over the past year, injecting it into patients\u2019 breasts, butts, and hip dips to lend modest volume and round out curves in a conservative\u2014I repeat: conservative<\/em>\u2014fashion. This is not a means to a massive rear end. \u201cIt\u2019s intended for really elegant contouring,\u201d says Dr. Shridharani. He\u2019s also used Alloclae to remedy \u201cdevastating deformities\u201d caused by aggressive energy-assisted liposuction. \u201cI see this all the time\u2014thin patients with contour irregularities from liposuction gone awry,\u201d he says. Most \u201cweren\u2019t really lipo candidates, but their surgeons\u2026 took a shot at it, piecemealing together what they thought would be enough fat to give a good outcome.\u201d<\/p>\n

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Before (left) and after correction of liposuction contour deformity (from another surgeon) using Alloclae. Courtesy of Dr. Darren Smith.<\/p>\n

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When discussing risks with Alloclae patients, plastic surgeons tend to follow a similar script to the one they use for other fat-grafting patients, says Dr. Gordon. In addition to expected side effects, like bruising, swelling, and soreness, possible complications include bleeding, infection, palpable lumps, fat necrosis [tissue death], oil cysts, and underwhelming results. Some surgeons argue that necrosis and cysts may be less of a risk with Alloclae than with a patient\u2019s own fat, since Alloclae doesn\u2019t contain living cells with the potential to die and cause those problems.<\/p>\n

A Non-Surgical, Implant-Free Breast Augmentation<\/div>\n

In some practices, Alloclae is proving to be a viable alternative to implants. \u201cWe see so many women wanting a modest breast enhancement without implants,\u201d says Dr. Pittman\u2014a wish that has historically been granted with fat grafting. But with 75% of these patients, he says, \u201cI can tell within a minute of meeting them that they\u2019re not a candidate for fat transfer, because they\u2019re already very thin.\u201d Before Alloclae, a surgeon in this scenario had two choices: Turn the patient away or attempt to liposuction multiple areas\u2014arms, back, thighs, tummy\u2014and risk traumatizing those body parts in order to get enough fat to make a significant difference. But with Alloclae as an option, \u201cwe don\u2019t have to do all that liposuction, we don\u2019t need to use general anesthesia, and we can get a meaningful boost in volume,\u201d says Dr. Zeidler. \u201cWe can do Alloclae in the office, under local, and you can drive yourself home after.\u201d<\/p>\n

Surgeons inject Alloclae as they would fat, evenly distributing small droplets with a blunt-tip cannula. \u201cI numb the insertion site, and once the cannula is in, the patient may feel pressure, and every once in a while a little zing, but they don\u2019t feel pain,\u201d says Dr. Pittman. When treating the breasts, Dr. Shridharani says he typically makes two two-millimeter incisions (as cannula entry points), one in the breast fold and another at the outer rim of the areola.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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The first time Dr. Zeidler used Alloclae, she was treating a woman who\u2019d had a \u201cpretty aggressive explant [breast implant removal] surgery\u201d (done elsewhere) that left her with a flat chest. They started with two rounds of fat transfer, after which the patient desired more volume, but wasn\u2019t up for another round of lipo. She then tried Alloclae and \u201csaw such a meaningful difference from just 50 ccs, which is a much smaller amount than I ever did with fat transfer,\u201d Dr. Zeidler says. Three months later, they did another round of Alloclae and the patient was \u201cecstatic\u201d with her results. She\u2019s now planning a third session, Dr. Zeidler says, \u201cto get to a nice full C cup.\u201d<\/p>\n

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Before (left) and after using Alloclae to make breasts appear fuller. Courtesy of Dr. Kamakshi R. Zeidler.<\/p>\n

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The size increase achievable with Alloclae depends largely on breast anatomy\u2014in particular, the elasticity of the tissues. When the breasts are very tight, they may not be able to accommodate more than 50 ccs each in a single round, says Dr. Zeidler. But \u201cthat\u2019s usually enough to give at least a half-cup boost in volume.\u201d Some women don\u2019t care about bra size so much as \u201cfilling out bathing suits,\u201d she adds, and 50 ccs (or even less) of Alloclae can lend nice shape to the tops of the breast to enhance cleavage (though not as effectively as an implant). When patients have bigger breasts or more laxity of their tissues\u2014and, thus, more space to fill\u2014Dr. Zeidler says she can add up to 150 ccs of Alloclae per side for \u201cmore than a cup-size increase.\u201d She likes to err on the conservative side, since this is a non-surgical procedure and it\u2019s usually easy enough for patients to come back for a little bit more if needed.<\/p>\n

Like Dr. Zeidler, Dr. Shridharani says he can deliver one to two cup sizes with Alloclae, but getting there might require a couple of sessions, a few months apart. It\u2019s important to gradually build volume based on what an individual breast can reasonably hold. The other surgeons I spoke to are, for now, using Alloclae more sparingly in the breasts\u201425 to 50 ccs per side\u2014usually in conjunction with implants (to veil visible edges or rippling) or after removing implants \u201cto fill out the concavity at the tops of the breasts,\u201d says Dr. Gordon, who\u2019s an advisor to the brand. Wherever Alloclae is used, \u201cit\u2019s important to go slow and be really careful, because this is human tissue,\u201d she says. \u201cIt\u2019s not just like a hyaluronic acid filler that we can dissolve with a shot of enzyme.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Before (left) and after using Alloclae to enhance the breasts. Courtesy of Dr. Sachin M. Shridharani.<\/p>\n

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Dr. Shridharani is also seeing \u201ca huge demand\u201d for Alloclae in patients who previously had breast reductions or lifts, and then went on GLP-1s, lost 20 to 30 pounds, and saw their breasts shrink. Assuming their skin quality is still good, and their tissues haven\u2019t stretched, Alloclae can offer a relatively simple solution. (As Allure<\/em> previously reported, GLP-1 medications are anecdotally linked to impaired collagen production in the skin, primarily because they prompt caloric restriction and nutritional deficiencies.)<\/p>\n

I should note that plastic surgeons are somewhat split on the usefulness of Alloclae in GLP-1 patients overall. Dr. Smith says he\u2019s excited to see Alloclae \u201copen up the world of fat transfer to GLP-1 patients who\u2019ve lost volume\u2014 maybe not from where they wanted to\u2014and don\u2019t have a lot of fat to donate to the cause.\u201d Likewise, Dr. Shridharani says Alloclae can come in handy in cases where he\u2019d rather not risk creating or exacerbating skin laxity by suctioning what little fat GLP-1 patients have left. Other surgeons see less of a role for Alloclae in this group, especially as a standalone treatment, because these patients often have loose tissue that needs to be tailored and reshaped. In GLP-1 breast patients, \u201cI\u2019m more reliably using implants to create structure,\u201d notes Dr. Zeidler. \u201c These women generally need breast lifts, as well, to reduce excess skin.\u201d She may use Alloclae after, to fine-tune the results, but it\u2019s not going to save the patient from having surgery, which is ordinarily part of the product\u2019s appeal.<\/p>\n

How Alloclae Compares to Implants and Native Fat<\/div>\n

The Alloclae aesthetic is distinct from that of breast implants and more akin to that of fat, though not a carbon copy. Implants offer predictable volume\u2014\u201cif we put in a 280 cc implant, we know your breast is going to change by 280 ccs,\u201d says Dr. Pittman\u2014and impart structure, giving the breast a shape to conform to. Fat, on the other hand, is amorphous and creates a more natural effect. Dr. Shridharani explains the difference to patients like this: \u201cYour breast will take on the shape of an implant, be it round or tear-drop, but fat takes on the shape of your breast.\u201d Following fat grafting, \u201cyour breast will still look like your breast, only fuller.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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Alloclae falls somewhere in between. Surgeons find it to be thicker and more structural than fat\u2014\u201cit\u2019s giving a lot of lift and shape,\u201d notes Dr. Zeidler\u2014likely due to the way it\u2019s purified and concentrated. When discussing breast augmentation options with patients, Dr. Zeidler puts \u201csoft, fluffy\u201d fat at one end of the spectrum and implants at the other. In the middle is Alloclae: \u201cCompared to fat transfer, Alloclae is providing a more meaningful boost in volume and giving more oomph, cc per cc,\u201d she says. And so far, \u201cit\u2019s looking like the volume we\u2019re putting in is very stable and reliable.\u201d<\/p>\n

Dr. Gordon, who\u2019s been using Alloclae for just over a year, says she, too, has found it to be very predictable in terms of long-term gains. \u201cIn my experience, the take and retention are really good\u2014like 90% to 100% of what we inject sticks around,\u201d she says. In the first few days after treatment, patients tend to swell. \u201cSome will call me, worried, because it can look bulgy at first, but usually by a week or two, it\u2019s settled down and you can see the correction.\u201d<\/p>\n

While studies are being done by the company to quantify Alloclae results at six months and one year, the surgeons I spoke to, who\u2019ve been using it for the past year, have been pleased with the product\u2019s longevity. \u201cIt\u2019s almost like what you see on the table is what you get,\u201d says Dr. Shridharani. Since Alloclae can be injected with patients awake, Dr. Shridharani will sometimes have people stand up and look at themselves in the mirror to assess their results. If they like what they see, he might put in a tiny bit more to account for temporary swelling, but otherwise, he says he doesn\u2019t expect the outcome to change very much, because, in his experience, \u201cthere\u2019s not a lot of resorption.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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With fat grafting, on the other hand, survival and durability can vary based on myriad factors, including the specific ways in which the fat is collected, handled, processed, and reinjected. In the past, doctors would routinely estimate that about 50% of grafted fat would take. Today, some of the more advanced fat harvesting systems boast retention rates of 75 to 80 percent.<\/p>\n

Dr. Pittman, who started using Alloclae in January, says he\u2019s been surprised by how well the product performs, especially compared to fat. \u201cIf I were going to graft the upper [portion] of the breast with regular fat, I would need at least 150 ccs of fat for each side, knowing that 50% or 60% may stay and the rest will resorb,\u201d he says. \u201cWith Alloclae, I\u2019m using only 50 ccs in each breast to do this, and we don\u2019t see things deflating months later. That\u2019s what\u2019s so phenomenal\u2014the resorption rate seems to be way less than what we see with patients\u2019 own fat.\u201d<\/p>\n

At this point, however, Alloclae has been in use for just over a year and \u201cthere\u2019s really no data to support what I\u2019m saying here,\u201d Dr. Pittman tells me. \u201cThere\u2019s been no real study that I\u2019m aware of looking at overall retention using imaging [to measure volume changes].\u201d He\u2019s very honest with patients about this and careful not to overpromise. \u201cI tell them, fat transfer is unpredictable and we have data,\u201d he says. \u201cAlloclae is unpredictable and we don\u2019t have data.\u201d While anecdotal reports are overwhelmingly positive and Dr. Pittman certainly sees a role for Alloclae, \u201cI\u2019ll feel better when we have published long-term results,\u201d he says. \u201cSomething that seems all the rage right now might crash and burn in a year.\u201d<\/p>\n

While surgeons can\u2019t conclusively say if Alloclae rivals your own fat, many are cautiously optimistic. Dr. Smith calls the injectable a \u201csuper option\u201d for patients who are short on fat, but says he\u2019s still partial to the old-fashioned kind. \u201cAll things being equal, I\u2019m going to use native fat every time, simply because it\u2019s living tissue. And with any allogeneic [donor] product, there\u2019s going to be more uncertainty,\u201d he says. Still, other doctors are leaning into Alloclae, especially for small-volume tweaks that may not warrant the heavy-lift of lipo. While I\u2019m reluctant to label anything in the cosmetic realm a \u201cquick fix\u201d\u2014beyond trite, it trivializes medical procedures\u2014Alloclae, some experts insist, could prove to be just that.<\/p>\n

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Read more about the latest in aesthetics:<\/strong><\/p>\n

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  • Everyone\u2019s Signing Up for Jawline Liposuction<\/li>\n
  • A Kinder, Gentler Boob Job May Be Upon Us<\/li>\n
  • The “Glow-Up” Facelift Is Real<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n

    Source URL: https:\/\/www.allure.com\/story\/alloclae-injectable-filler-explainer<\/p>\n","protected":false},"excerpt":{"rendered":"

    FAT CHANCE Would You Get a Fat Transfer With Someone Else’s Fat? It\u2019s the newest frontier in regenerative medicine. We asked plastic surgeons for all the details, gory and otherwise. By Jolene Edgar November 19, 2025 Photography by Hannah Khymych These days, it\u2019s rare to write about plastic surgery without mentioning fat. We\u2019re either losing […]<\/p>\n","protected":false},"author":1,"featured_media":846936,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[52],"class_list":["post-846935","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-politics","tag-allure-com"],"_links":{"self":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/846935","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=846935"}],"version-history":[{"count":0,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/846935\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/media\/846936"}],"wp:attachment":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=846935"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=846935"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=846935"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}