{"id":514529,"date":"2025-02-23T11:37:27","date_gmt":"2025-02-23T08:37:27","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=514529"},"modified":"2025-02-23T11:37:27","modified_gmt":"2025-02-23T08:37:27","slug":"un-vaccin-impotriva-tuberculozei-bazat-pe-tehnologia-arnm-a-obtinut-rezultate-promitatoare-in-studiile-preclinice","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=514529","title":{"rendered":"Un vaccin \u00eempotriva tuberculozei bazat pe tehnologia ARNm a ob\u0163inut rezultate promi\u0163\u0103toare \u00een studiile preclinice"},"content":{"rendered":"<div class=\"post-content\">\n<p>Un nou vaccin care stimuleaz\u0103 imunitatea \u00eempotriva tuberculozei (TB) a demonstrat eficacitate \u00een studiile preclinice, realizate pe animale. Vaccinul a fost dezvoltat printr-o colaborare \u00eentre trei institu\u0163ii de cercetare din Australia, transmite News.ro.<\/p>\n<p>Noul vaccin a fost prezentat \u00eentr-un studiu publicat \u00een eBioMedicine, fiind realizat de exper\u0163i de la Sydney Infectious Diseases Institute din cadrul Universit\u0103\u0163ii din Sydney, Centenary Institute \u015fi Monash Institute of Pharmaceutical Science (MIPS) de la Universitatea Monash.<\/p>\n<p>\u00cen prezent, singurul vaccin aprobat \u00eempotriva TB este BCG (Bacillus Calmette-Guerin), vechi de un secol, a c\u0103rui eficacitate la adul\u0163i este inconsistent\u0103.<\/p>\n<p>Noul studiu a constatat c\u0103 vaccinul, dezvoltat utiliz\u00e2nd tehnologia ARN mesager (ARNm), a reu\u015fit s\u0103 declan\u015feze un r\u0103spuns imun care a contribuit la reducerea num\u0103rului de bacterii care provoac\u0103 tuberculoz\u0103 (Mycobacterium tuberculosis) la \u015foarecii infecta\u0163i.<\/p>\n<p>\u00cen plus, pentru \u015foarecii care au primit vaccinul BCG, o doz\u0103 de rapel cu noul vaccin ARNm le-a \u00eembun\u0103t\u0103\u0163it semnificativ protec\u0163ia pe termen lung.<\/p>\n<p>\u00cen tehnologia ARNm, instruc\u0163iuni genetice sunt folosite pentru a declan\u015fa un r\u0103spuns imun \u00een organism, spre deosebire de vaccinurile tradi\u0163ionale, care utilizeaz\u0103 versiuni sl\u0103bite sau inactivate ale unui virus.<\/p>\n<p>\u201eDescoperirile noastre demonstreaz\u0103 c\u0103 un vaccin ARNm poate induce r\u0103spunsuri imune puternice, specifice patogenului, care vizeaz\u0103 tuberculoza, o boal\u0103 care nu a mai beneficiat de mult timp de dezvoltarea unui vaccin eficient\u201d, a afirmat prof. Jamie Triccas, autor principal al studiului \u015fi director adjunct al Sydney Infectious Diseases Institute.<\/p>\n<p>Tuberculoza este principala cauz\u0103 de mortalitate infec\u0163ioas\u0103 la nivel mondial, responsabil\u0103 pentru aproximativ 1,3 milioane de decese \u00een fiecare an, cu o prevalen\u0163\u0103 deosebit\u0103 \u00een \u0163\u0103ri precum India, Indonezia, Vietnam \u015fi Pakistan.<\/p>\n<p>Cercet\u0103torii sper\u0103 c\u0103 vaccinul ARNm se va dovedi mai eficient \u015fi mai consistent dec\u00e2t vaccinul BCG atunci c\u00e2nd va fi testat la oameni, \u00een studii clinice.<\/p>\n<p>Spre deosebire de vaccinurile pe baz\u0103 de proteine sau cele cu patogeni atenua\u0163i, vaccinurile ARNm permit o adaptare rapid\u0103, f\u0103c\u00e2ndu-le o op\u0163iune atractiv\u0103 pentru eforturile globale de control al tuberculozei.<\/p>\n<p>Dup\u0103 rezultatele promi\u0163\u0103toare din studiile preclinice, echipa de cercetare inten\u0163ioneaz\u0103 s\u0103 testeze vaccinul \u00een studii clinice.<\/p>\n<div class=\"code-block code-block-15\">\n<h4>Urm\u0103re\u0219te mai jos produc\u021biile video ale G4Media:<\/h4>\n<\/div>\n<\/div>\n<p> Source URL: https:\/\/www.g4media.ro\/un-vaccin-impotriva-tuberculozei-bazat-pe-tehnologia-arnm-a-obtinut-rezultate-promitatoare-in-studiile-preclinice.html<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Un nou vaccin care stimuleaz\u0103 imunitatea \u00eempotriva tuberculozei (TB) a demonstrat eficacitate \u00een studiile preclinice, realizate pe animale. Vaccinul a fost dezvoltat printr-o colaborare \u00eentre trei institu\u0163ii de cercetare din Australia, transmite News.ro. Noul vaccin a fost prezentat \u00eentr-un studiu publicat \u00een eBioMedicine, fiind realizat de exper\u0163i de la Sydney Infectious Diseases Institute din cadrul [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":514530,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[24],"class_list":["post-514529","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-politics","tag-g4media"],"_links":{"self":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/514529","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=514529"}],"version-history":[{"count":0,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/514529\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/media\/514530"}],"wp:attachment":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=514529"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=514529"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=514529"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}