{"id":2224764,"date":"2026-10-27T18:36:56","date_gmt":"2026-10-27T15:36:56","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=2224764"},"modified":"2026-10-27T18:36:56","modified_gmt":"2026-10-27T15:36:56","slug":"pas-urias-in-lupta-cu-cancerul-o-noua-combinatie-de-medicamente-reduce-riscul-de-deces-cu-58","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=2224764","title":{"rendered":"Pas uria\u0219 \u00een lupta cu cancerul: O nou\u0103 combina\u021bie de medicamente reduce riscul de deces cu 58%"},"content":{"rendered":"<p>[analyse_image type=&#8221;featured&#8221; src=&#8221;https:\/\/cdn.adh.reperio.news\/image-1\/14c94ceb-d5cc-4beb-b305-7361cd3c8580\/index.jpeg?p=f%3Djpeg%26w%3D1200%26h%3D630%26r%3Dcover&#8221;]<\/p>\n<article class=\"svelte-x63bga\">\n<nav>\n<ul class=\"breadcrump svelte-1pk9a69\">\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/\" title=\"Adev\u0103rul\" class=\"svelte-1pk9a69\">Home<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\" class=\"svelte-1pk9a69\">Stil de via\u021b\u0103<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\/stiinta\" class=\"svelte-1pk9a69\">\u0218tiin\u021b\u0103<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\/stiinta\/pas-urias-in-lupta-cu-cancerul-o-noua-combinatie-2566990.html\" class=\"svelte-1pk9a69\">Pas uria\u0219 \u00een lupta cu cancerul: O nou\u0103 combina\u021bie de medicamente reduce riscul de deces cu 58%<\/a><\/li>\n<\/ul>\n<\/nav>\n<p><main class=\"svelte-x63bga\"><\/p>\n<p>O combina\u021bie de medicamente testat\u0103 la pacien\u021bii cu cancer pulmonar cu celule mici, o form\u0103 agresiv\u0103 a bolii, a redus riscul de deces cu 58% fa\u021b\u0103 de tratamentul standard utilizat singur. Rezultatele studiului arat\u0103 \u0219i o cre\u0219tere a duratei mediane de supravie\u021buire cu peste opt luni.<\/p>\n<div class=\"container-image  svelte-1xbw4f3\"><source type=\"image\/webp\" srcset=\"https:\/\/cdn.adh.reperio.news\/image-1\/14c94ceb-d5cc-4beb-b305-7361cd3c8580\/index.jpeg?p=a%3D1%26co%3D1.05%26w%3D1400%26h%3D750%26r%3Dcontain%26f%3Dwebp 1400w\" media=\"(min-width: 1400px)\" \/><\/p>\n<div class=\"caption svelte-1xbw4f3\"><span class=\"captionText svelte-1xbw4f3\">Cancerul pulmonar agresiv, tratat cu o nou\u0103 combina\u021bie de medicamente <span class=\"source svelte-1xbw4f3\">Foto: Cancer Treatment Centers of America<\/span><\/span><\/div>\n<\/div>\n<p>Medicamentul Imdelltra, dezvoltat de compania Amgen, administrat \u00eempreun\u0103 cu imunoterapia Imfinzi, produs\u0103 de AstraZeneca, a redus riscul de deces cu 58% \u00een compara\u021bie cu administrarea exclusiv\u0103 a medicamentului Imfinzi, la pacien\u021bii cu cancer pulmonar cu celule mici \u00een stadiu extins. Datele provin dintr-un studiu prezentat s\u00e2mb\u0103t\u0103, \u00een cadrul unei conferin\u021be medicale importante, potrivit <a href=\"https:\/\/www.reuters.com\/legal\/litigation\/amgen-drug-combined-with-immunotherapy-extends-survival-lung-cancer-trial-2026-10-24\/\" rel=\"nofollow\">Reuters.<\/a><\/p>\n<p>\u00cen prezent, Imfinzi reprezint\u0103 tratamentul standard dup\u0103 chimioterapie pentru pacien\u021bii cu aceast\u0103 form\u0103 de cancer, extrem de agresiv\u0103 \u0219i dificil de tratat, la care boala nu progreseaz\u0103 dup\u0103 administrarea ini\u021bial\u0103 a chimioterapiei.<\/p>\n<p>Studiul a ar\u0103tat c\u0103 pacien\u021bii care au primit ambele medicamente au avut o supravie\u021buire median\u0103 de 21,1 luni, comparativ cu 12,7 luni \u00een cazul celor trata\u021bi doar cu Imfinzi.<\/p>\n<p><i>\u201eDac\u0103 administrezi Imdelltra din ce \u00een ce mai devreme, ob\u021bii beneficii clinice mai mari\u201d<\/i>, a declarat Paul Burton, directorul medical al companiei Amgen, cu sediul \u00een California. Acesta a descris rezultatele drept<i> \u201ef\u0103r\u0103 precedent \u00een avansarea tratamentului cancerului pulmonar cu celule mici \u00een stadiu extins\u201d.<\/i><\/p>\n<h2>Imdelltra ar putea genera v\u00e2nz\u0103ri anuale de peste 2,5 miliarde de dolari<\/h2>\n<p>Pre\u021bul de list\u0103 al Imdelltra \u00een Statele Unite este de aproximativ 30.000 de dolari pentru un ciclu de tratament, ceea ce \u00eenseamn\u0103 peste 390.000 de dolari pe an. Anali\u0219tii de pe Wall Street estimeaz\u0103 c\u0103 v\u00e2nz\u0103rile anuale ale medicamentului ar putea dep\u0103\u0219i 2,5 miliarde de dolari p\u00e2n\u0103 \u00een 2030, conform datelor LSEG.<\/p>\n<p>\u00cen prezent, medicamentul Amgen este aprobat pentru adul\u021bii cu <a href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/descoperire-revolutionara-un-test-de-sange-ar-2495941.html\">cancer pulmonar cu celule mici<\/a> \u00een stadii avansate, la care boala a progresat \u00een ciuda chimioterapiei. Aprobarea s-a bazat pe date care au ar\u0103tat c\u0103 Imdelltra a redus riscul de deces cu 40% \u00een acest context.<\/p>\n<p>Rezultatele complete ale studiului, care a inclus 563 de pacien\u021bi, au fost prezentate \u00een cadrul reuniunii Societ\u0103\u021bii Europene de Oncologie Medical\u0103, organizat\u0103 la Madrid, \u0219i publicate \u00een revista New England Journal of Medicine. Amgen anun\u021base anterior c\u0103 studiul clinic de faz\u0103 a III-a a avut rezultate pozitive.<\/p>\n<h2>Cum ac\u021bioneaz\u0103 cele dou\u0103 medicamente<\/h2>\n<p>Imdelltra face parte dintr-o clas\u0103 de medicamente numite anticorpi bispecifici, concepu\u021bi s\u0103 aduc\u0103 \u00een contact celulele T ale sistemului imunitar \u0219i celulele canceroase, astfel \u00eenc\u00e2t primele s\u0103 le poat\u0103 distruge.<\/p>\n<p>Imfinzi este o form\u0103 mai veche de imunoterapie, care blocheaz\u0103 mecanismul prin care tumorile se ascund de atacul sistemului imunitar.<\/p>\n<p>Cele mai multe <a href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/boala-care-face-prapad-in-romania-8-oameni-isi-2450554.html\">cazuri de cancer pulmonar<\/a> sunt reprezentate de formele f\u0103r\u0103 celule mici. Cancerul pulmonar cu celule mici, forma vizat\u0103 de Imdelltra, reprezint\u0103 p\u00e2n\u0103 la 15% din totalul cazurilor. La nivel mondial, sunt diagnosticate anual aproximativ 250.000 de cazuri noi, potrivit Institutelor Na\u021bionale de S\u0103n\u0103tate din Statele Unite (NIH).<\/p>\n<p>Foarte pu\u021bini dintre pacien\u021bii diagnostica\u021bi cu aceast\u0103 form\u0103 de cancer pot fi opera\u021bi, iar majoritatea primesc ini\u021bial radioterapie \u0219i chimioterapie, a explicat Paul Burton.<\/p>\n<p>Ratele de supravie\u021buire depind de momentul diagnostic\u0103rii bolii. Cu toate acestea, rata general\u0103 de supravie\u021buire la cinci ani este de numai aproximativ 9%, potrivit Societ\u0103\u021bii Americane de Cancer.<\/p>\n<h2>Aproape 80% dintre pacien\u021bii trata\u021bi cu ambele medicamente au supravie\u021buit un an<\/h2>\n<p>Potrivit Amgen, aproape 80% dintre pacien\u021bii inclu\u0219i \u00een studiu care au primit combina\u021bia de medicamente erau \u00een via\u021b\u0103 dup\u0103 un an, comparativ cu 53% dintre cei trata\u021bi exclusiv cu Imfinzi. Monitorizarea pacien\u021bilor continu\u0103.<\/p>\n<p>Tratamentul combinat a fost asociat \u00eens\u0103 \u0219i cu o frecven\u021b\u0103 mai mare a unor reac\u021bii adverse grave. Acestea, inclusiv sc\u0103derea num\u0103rului de globule albe din s\u00e2nge, au fost raportate la 20,9% dintre pacien\u021bii care au primit ambele medicamente, fa\u021b\u0103 de 10,8% \u00een grupul tratat doar cu Imfinzi.<\/p>\n<p>Un alt efect advers, sindromul de eliberare a citokinelor, o reac\u021bie inflamatorie intens\u0103 \u0219i poten\u021bial periculoas\u0103, a fost raportat la 49,6% dintre pacien\u021bii care au primit Imdelltra. Dintre aceste cazuri, unul singur a fost grav. Nu au fost \u00eenregistrate decese asociate acestui sindrom.<\/p>\n<p>Reac\u021biile adverse au dus la \u00eentreruperea tratamentului combinat \u00een cazul a 5,7% dintre pacien\u021bi. \u00cen grupul care a primit exclusiv Imfinzi, propor\u021bia a fost de 5,8%.<\/p>\n<p><\/main><\/p>\n<footer class=\"svelte-x63bga\">\n<div class=\"related-wrap related-footer svelte-78g0vl\"><span class=\"related-label svelte-78g0vl\">Cite\u0219te \u0219i<\/span><a class=\"related svelte-78g0vl\" data-gtrack=\"{&quot;event&quot;:&quot;utm_click&quot;,&quot;data&quot;:{&quot;event_category&quot;:&quot;article_related&quot;}}\" href=\"https:\/\/adevarul.ro\/stil-de-viata\/magazin\/inteligenta-artificiala-schimba-lupta-cu-cancerul-2565081.html\" title=\"Alt articol de interes pentru tine\"><img decoding=\"async\" class=\"thumb svelte-78g0vl\" src=\"https:\/\/cdn.adh.reperio.news\/image-b\/ba1525eb-49bc-48f6-b59c-ce275556e634\/index.jpeg?p=f%3Dwebp%26w%3D120%26h%3D80%26r%3Dcover%26a%3D0\" alt loading=\"lazy\" width=\"80\" height=\"54\"><span class=\"title svelte-78g0vl\">Inteligen\u021ba artificial\u0103 schimb\u0103 lupta cu cancerul. 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