{"id":2061372,"date":"2026-07-25T07:12:47","date_gmt":"2026-07-25T04:12:47","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=2061372"},"modified":"2026-07-25T07:12:47","modified_gmt":"2026-07-25T04:12:47","slug":"an-altitude-alibi-does-cyclings-anti-doping-system-have-a-major-loophole","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=2061372","title":{"rendered":"An altitude alibi: Does cycling&#8217;s anti-doping system have a major loophole?"},"content":{"rendered":"<p>[analyse_image type=&#8221;featured&#8221; src=&#8221;https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-2000-80.jpg&#8221;]<\/p>\n<p><article class=\"page-content-onecol flex-1\nnews-article article\n\"><\/p>\n<div class=\"widget-area-group widget-area-group-2col flex flex-wrap box-border\">\n<div id=\"widgetArea16\" class=\"widget-area basis-full md:basis-2\/3 widget-area-g-md-vp-2-3 widget-area-g-lg-vp-2-3 widget-area-g-xl-vp-2-3 page-widget-area-16\">\n<div data-widget-type=\"hero\" id=\"hero\" class=\"clear-both widget widget-hero widget-hero widget-hero-hero widget-hero widget-hero-fter-news\">\n<div class=\"news-article\">\n<header data-component-name=\"Article:Hero\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumbs\">\n<ol>\n<li>\nPro Cycling\n<\/li>\n<li>\nRules\n<\/li>\n<li>\nDoping\n<\/li>\n<\/ol>\n<\/nav>\n<h1>An altitude alibi: Does cycling&#8217;s anti-doping system have a major loophole?<\/h1>\n<div class=\"kiosq-member-label\" data-component-name=\"Article:Hero:KiosqPaywallLabels\"><span class=\"kiosq-member-label-text\"><br \/>\nMEMBER EXCLUSIVE<br \/>\n<\/span><\/div>\n<div class=\"byline-social\">\n<div class=\"vds-byline-block flex flex-row flex-nowrap my-1.5 gap-2 text-left items-start justify-center mx-auto max-sm:text-center max-sm:items-center\" data-component-name=\"Article:BylineBlock\">\n<p>Features<\/p>\n<div class=\"my-auto vds-simple-byline\"><span class=\"inline-block vds-author\"><br \/>\nBy<br \/>\nJames Witts <\/span><\/p>\n<div class=\"flex gap-1 vds-byline-with-avatar__meta max-sm:justify-center\"><span class=\"vds-date block font-normal tracking-normal normal-case text-xs\"><br \/>\nPublished<br \/>\n<time data-component-name=\"UI:DateTime\" datetime=\"2026-07-25T07:12:47Z\" class=\"relative-date\"><br \/>\n25 July 2026<br \/>\n<\/time><\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"strapline\">Cycling&#8217;s recent nighttime anti-doping wake-up calls highlighted concerns that micro-dosing is fuelling an ever-accelerating peloton. Further concerns arise from the similar biological footprints left by hypoxic adaptation and artificial EPO. Is modern-day cycling as clean as we hoped? Cyclingnews investigates\u2026<\/p>\n<\/div>\n<aside class=\"text-gray-700 flex items-center mx-0 my-5 p-0 justify-center text-center\" id=\"affiliate-disclaimer\" data-component-name=\"AffiliateDisclaimer\" data-hawk-message=\"Affiliate disclaimer removed because hawk deemed there are no affiliate links on this page\">\n<p class=\"text-[color:var(--affiliate-disclaimer--text-color,inherit)] mb-2 text-[length:var(--affiliate-disclaimer--font-size,0.75rem)] leading-[18px] md:text-[13px] [&amp;&gt;a]:text-inherit [&amp;&gt;a]:underline\">\nWhen you purchase through links on our site, we may earn an affiliate commission. Here\u2019s how it works.\n<\/p>\n<\/aside>\n<\/header>\n<\/div>\n<\/div>\n<div data-widget-type=\"contentparsed\" id=\"content\" class=\"clear-both widget widget-contentparsed widget-content widget-contentparsed-content widget-content-parsed widget-content-parsed-content_document \">\n<div class=\"wcp-item-content\">\n<section class=\"content-wrapper\">\n<div class=\"box less-space hero-image-wrapper\">\n<figure class=\"mb-0\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1600-80.jpg.webp 1600w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-750-80.jpg.webp 750w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><figcaption class=\"font-article-copy text-(--image--text--color) font-article-copy mt-2\"><span class=\"caption-text font-article-copy\">Altitude training only makes the jobs of anti-doping authorities harder given the similar biological footprints of hypoxic adaptation and artificial EPO<\/span><span class=\"credit font-article-copy\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<\/div>\n<div id=\"article-body\" class=\"text-copy bodyCopy auto paywall-locker\">\n<div data-analytics-id=\"utility-bar\" id=\"utility-bar\" class=\"font-ui-heading flex justify-between items-center py-2 border-t border-b border-gray-300 border-solid mb-5 mx-auto\" data-component-name=\"UtilityBar\" data-mrf-recirculation=\"utility-bar\">\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div data-component-name=\"Social:Dropdown\" role=\"menu\" id=\"utilitybar__dropdown--share\" aria-labelledby=\"utilitybar__button--share\" class=\"absolute left-0 top-full w-44 bg-white rounded-md shadow-md border border-neutral-200 z-[9996] list-none m-0 py-2 px-3 border-solid\">\n<ul class=\"m-0!\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Facebook<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>X<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Pinterest<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Email<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-share-this-article\" role=\"tooltip\" aria-hidden=\"true\">\nShare this article\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\"><span class=\"ml-1 inline-flex h-5 px-2 shrink-0 items-center justify-center self-center overflow-hidden whitespace-nowrap rounded-[10px] bg-primary-500 text-[11px] leading-none font-ui-heading font-semibold text-white\">0<\/span><\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-join-the-conversation\" role=\"tooltip\" aria-hidden=\"true\">\nJoin the conversation\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<p>Follow us<\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-add-us-as-a-preferred-source-on-google\" role=\"tooltip\" aria-hidden=\"true\">\nAdd us as a preferred source on Google\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-subscribe-to-our-newsletter\" role=\"tooltip\" aria-hidden=\"true\">\nSubscribe to our newsletter\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a\">As I write this, online is abuzz with Jonas Vingegaard crashing out of this year\u2019s Tour de France. The potential cause? Being awoken at 2 a.m. for an anti-doping test. Tadej Poga\u010dar, wrote <em>The Guardian<\/em>\u2019s Jeremy Whittle, said the disturbance could &#8220;be a small percentage in why he crashed because he probably didn\u2019t sleep good&#8221;, adding: &#8220;I know how it feels. They woke me up at five in the morning also, but at least I got my deep sleep. It\u2019s better than if they come at two.&#8221; Why were the Dane and Slovenian woken between 11 p.m. and 6 a.m., which is uncommon from the International Testing Agency (ITA), who roll out the anti-doping programme on behalf of the UCI? No official reasons have been given, and being selected for a test, including out of hours, is a standard part of anti-doping controls, and does not imply any suspicion of, or wrongdoing by, the riders concerned.<\/p>\n<p>However, when WADA first permitted nighttime testing across all its sports in 2015, there was a reason for it. The Cycling Independent Reform Commission (CIRC) stated in 2015 that &#8220;the absence of nighttime testing [was] a weakness in the current system&#8221;, specifically regarding the issue of micro-dosing.<\/p>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a-2\" aria-hidden=\"true\" class=\"kiosq-b\">Here, we delve deep into micro-dosing\u2019s detection challenge, made harder by the issue of altitude\u2026<\/p>\n<h2 id=\"the-science-says-no-3\" aria-hidden=\"true\" class=\"kiosq-b\">The science says \u2018no\u2019<\/h2>\n<p id=\"elk-2c91627e-8688-11f1-8223-458f0831d746\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;In 2010, Carsten Lundby and I had a <u>study<\/u> published [in the European Journal of Applied Physiology] where we sent anonymous doped EPO [the blood-booster erythropoietin] samples to anti-doping laboratories in Cologne and Lausanne to see if the results would come back positive. The results were poor. Not because the technicians are poor, but the gaps in the test, especially the passport.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The words of Dr Paul Robach, who works in the department of biomedical research at the National School of Mountain Sports, Chamonix, France. Robach is a world-leading authority on the blood changes fuelled by either the needle or a mountain.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Back to his eye-opening 2010 research. Half of the subjects who were injected with a significant amount of EPO before moving into the micro-dosing maintenance phase tested negative. Concerning. The World Anti-Doping Agency would rightly counter that the sensitivity of doping tests has improved in the intervening 16 years. Still, in my new book <em>Dope<\/em> it became clear that the micro-dosing shortcomings remained, one of the major flaws being rapidly flushed-out markers.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a3bc-873f-11f1-8dcc-933486d78dbe\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The ITA carried out several nighttime tests at the Tour de France recently <\/span><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<p id=\"elk-c7c3a42a-873f-11f1-80fc-c5204e01f89f\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;If a rider micro-dosed EPO at 11 p.m. and the doping control officer tested them at six the next morning, they\u2019d catch them with a direct blood test,&#8221; says Robach. &#8220;But the chances would be lower with the passport. It\u2019s because EPO has a short half-life of a few hours.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A direct doping test looks for a prohibited substance or its metabolites in an athlete\u2019s urine or blood, providing evidence that a banned drug has been used. The blood test doesn\u2019t search for specific substances. Instead, it tracks an athlete\u2019s blood markers over time and flags up unusual changes that may indicate doping. While direct tests aim to catch the substance itself, the blood passport is designed to detect the lasting biological effects of doping.<\/p>\n<h2 id=\"in-search-of-more-oxygen-3\" aria-hidden=\"true\" class=\"kiosq-b\">In search of more oxygen<\/h2>\n<p id=\"elk-2c91636e-8688-11f1-a262-a789e4d8a7c0\" aria-hidden=\"true\" class=\"kiosq-b\">Ultimately, no intelligence agency will communicate the reasons behind targeted or nocturnal testing. But the nighttime testing at the Tour does highlight a limitation of anti-doping procedures when it comes to micro-doping, which is exacerbated when trying to unpick the physiological changes accrued from synthetic EPO compared to altitude-stimulated EPO.<\/p>\n<div class=\"fancy-box kiosq-b\" id=\"elk-e2f7bdcc-87f7-11f1-b66b-2d5e5a6bb950\" aria-hidden=\"true\">\n<div class=\"fancy_box-title\">More features like this&#8230;<\/div>\n<div class=\"fancy_box_body\">\n<figure class=\"van-image-figure \">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-2560-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<ul>\n<li><strong>What to know about Tour de France nighttime testing \u2013 The rules, the results timeline, the ITA, reactions and more explained<\/strong><\/li>\n<li><strong>&#8216;Nowhere else would we accept that level of surveillance&#8217; \u2013 Between Whereabouts, nighttime testing and &#8216;clean anxiety&#8217;, is the anti-doping system in need of reform?<\/strong><\/li>\n<li><strong>&#8216;It\u2019s a wild west of doping activity&#8217; &#8211; How cycling&#8217;s amateur scene has become the epicentre for doping<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"elk-e2f7be44-87f7-11f1-b980-e5729c83d50e\" aria-hidden=\"true\" class=\"kiosq-b\">Which is perhaps not surprising, as the aim of each intervention is the same: to boost red blood cells, meaning the rider can tap into more oxygen to fuel working muscles. Achieving that goal by injection is prohibited. Heading high and forcing the oxygen-starved body to generate more EPO to create more red blood cells isn\u2019t.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A <u>2022 paper<\/u> by Jonas Saugy highlighted the problem, the researcher revealing that an athlete\u2019s blood profile when micro-dosing was &#8220;hardly distinguishable from those identified after hypoxic exposure&#8221; without doping.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The similar blood profiles included haemoglobin mass, which is the total amount of haemoglobin (oxygen carrier) in a rider\u2019s red blood cells. There\u2019s a tight relationship between VO2 max and haemoglobin mass, with research revealing that a 1g increase in haemoglobin mass can increase VO2 max by around 4ml\/min\/kg. As VO2 max is one of the limiting factors when it comes to an endurance sport like road cycling, the benefits are clear.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Further separate research highlights similar benefits enjoyed from micro-dosing and training at altitude. A <u>2024 study<\/u> revealed that injecting nine IU\/kg of bodyweight of EPO three times weekly over four weeks boosted endurance by up to 6% in trained athletes, which would equate to around 2% in elites, who have less room to grow.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">As for altitude training, a 2016 meta-analysis of elite athletes reported an average VO2max increase of around 2%, so similar to those micro-dosing results.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a4a2-873f-11f1-8610-9328df48c900\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">Tenerife and its iconic Teide volcano is a popular altitude training location for WorldTour cyclists <\/span><span class=\"credit\">(Image credit: Nicolas Economou\/NurPhoto via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"the-variability-of-altitude-training-3\" aria-hidden=\"true\" class=\"kiosq-b\">The variability of altitude training<\/h2>\n<p id=\"elk-2c9164a4-8688-11f1-86ad-9925d1ea9434\" aria-hidden=\"true\" class=\"kiosq-b\">It begs the question: why cheat when the legal means (altitude) deliver similar gains? &#8220;A rider\u2019s response to altitude training is highly variable,&#8221; says Robach. &#8220;We have an ongoing study that shows our group\u2019s haematological response to one year at high altitude varies from 1% to 50%.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach\u2019s results mirror earlier <u>research<\/u> charting how elite endurance athletes respond to altitude training camps and whether they can be reliably classified as &#8220;responders&#8221; or &#8220;non-responders.&#8221; Researchers analysed 82 altitude camps involving 59 athletes and measured changes in haemoglobin mass.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Haemoglobin mass increased after 56% of camps, rising to 65% when athletes trained above 2,000 metres (we\u2019ll come back to that height-related stimulus shortly). However, responses varied greatly both between athletes and within the same athlete across different camps.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;From the 15 athletes who participated in altitude training camps at least twice, 27% always had positive haemoglobin responses; 60% both positive and negative responses; and 13% only negative responses.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">In other words, altitude training doesn\u2019t always work. Worse than that for the rider and support staff, it might work for a rider at one camp but not at the next.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologist Inigo Mujika would suggest this variability\u2019s down to sidestepping the five I\u2019s. These are: Iron \u2013 inadequate iron intake may compromise adaptations to altitude; Intake \u2013 low energy diets don\u2019t support adaptations; Injury \u2013 prolonged inflammatory responses associated with serious soft tissue injury can interfere with adaptation; Illness \u2013 viral and bacterial infections do the same; and Intensity \u2013 excessive workload at the start of an altitude camp can promote excessive fatigue and, again, impair adaptation.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even with the best-laid plans, results from altitude training remain inconsistent. One reason why is limitations in how low each rider can go\u2026<\/p>\n<h2 id=\"triggering-hif-1-3\" aria-hidden=\"true\" class=\"kiosq-b\">Triggering HIF-1<\/h2>\n<p id=\"elk-2c91658a-8688-11f1-a342-df9d5ddc3877\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Ultimately, optimising altitude training is around the amount that you can safely reduce your oxygen saturation level [SpO2], which you can measure with a pulse oximeter on the tip of your finger,&#8221; says top coach and sport scientist Dan Healey, who formerly worked with Alberto Contador at Tinkoff-Saxo. A normal range at sea level is around 95 to 100%. When you train at altitude, the thinner air naturally means that [it] usually drops. &#8220;You\u2019ll aim for the rider\u2019s SpO2 to drop to 90 and into the 80s. The sweet spot for optimum EPO production is probably in the 70s.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Healey says you need that rarefied stimulus to trigger a protein complex called hypoxia-inducible factor-1 alpha (HIF-1 alpha). &#8220;Every day, HIF-1 alpha is produced but killed. It\u2019s a really complex mechanism. But when you go to altitude, it\u2019s free to do its thing. HIF-1 alpha will join with HIF-2. That\u2019s when you get EPO production and why teams spend a lot of money on altitude camps. Basically, they\u2019re spending top dollar to trigger HIF-1.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even when ticking those five \u2018I\u2019 boxes of Mujika\u2019s, how much HIF-1 alpha is triggered can vary greatly. In <em>Dope<\/em>, Rory Townsend told me that no matter what he does, his SpO2 levels remain well into the 90s. He\u2019s seemingly a staunch non-responder. That said, he\u2019s never hit the lofty heights of Healey\u2019s recent research.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;The sweet spot for triggering HIF-1 is around 5,000m,&#8221; he says. &#8220;You\u2019ll need to do it in really short doses of extreme hypoxia \u2013 so SpO2 in the 70s for accelerated EPO release \u2013 though you must monitor the rider closely and ensure things are done safely.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\"><em>Cyclingnews <\/em>reiterates that this type of training should only be carried out under the supervision of expert medical guidance.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach agrees that adding a little more certainty from altitude training might require going higher than the 2-2,500m that most teams peak at. &#8220;But many coaches are concerned if they go too high the riders will be too fatigued or not sleep. I think it\u2019d be okay at 3-3,500m. But 5,000m? That\u2019s exploratory and yet to be scientifically proven.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologists and sports scientists love nothing more than consistency. That their research and applied practice delivers gains time and time again. It\u2019s repeatable. That\u2019s anathema to altitude training. Sometimes it works, sometimes it doesn\u2019t. But with micro-dosing EPO? &#8220;Ultimately, you\u2019ll have a higher chance of consistently boosting your haemoglobin mass with EPO than altitude,&#8221; says Robach. &#8220;Altitude training is complicated.&#8221;<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a51a-873f-11f1-8f01-bfb38d44e5f5\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The biological footprint similarities between hypoxic adaptation and artificial EPO make the ITA&#8217;s job even more challenging <\/span><span class=\"credit\">(Image credit: THOMAS SAMSON\/AFP via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"what-of-the-future-3\" aria-hidden=\"true\" class=\"kiosq-b\">What of the future?<\/h2>\n<p id=\"elk-2c91667a-8688-11f1-a5fa-298b66ae223f\" aria-hidden=\"true\" class=\"kiosq-b\">So, there are compelling reasons why a rider might micro-dose, especially at altitude, as there\u2019s evidence that you enjoy a double boost, again without testing negative unless tested close to injection time.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s also not solely about micro-dosing EPO. Both infusing your own blood and injecting human growth hormone at nominal levels deliver a physiological advantage and a small detection window.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Which is why a credible anti-doping system can\u2019t rely so much on the biological blood passport. Sidestepping the cost implications of research and implementing a new test that\u2019s legally watertight, are there new tests on the horizon that could actually solve the micro-dosing and altitude riddle?<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Possibly. While much of the focus has been on changes in reticulocytes and other red blood cell markers, an alternative approach may be to examine shifts in plasma volume. One of the primary physiological responses to altitude exposure is a reduction in plasma volume \u2013 the liquid component of blood \u2013 which can influence many of the variables monitored by the biological passport.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">WADA has already explored machine-learning models that estimate an athlete\u2019s expected plasma volume over time, using artificial intelligence to distinguish normal physiological variation from patterns consistent with doping. Although this would require an additional blood measurement, incorporating plasma volume estimates could help differentiate the effects of altitude exposure from those of EPO micro-dosing.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;There\u2019s also great potential in the area of omics,&#8221; says Robach. This taps into the ongoing work of Professor Yannis Pitsiladis, a leading advocate for applying omics technologies \u2013 genomics, transcriptomics, proteomics and metabolomics \u2013 to anti-doping. By analysing thousands of biological markers simultaneously, these approaches could reveal subtle signatures of EPO use, blood manipulation and other forms of doping, potentially improving detection.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Exploring iron metabolism could pay off, too,&#8221; adds Robach, who along with colleagues has shown that even low doses of recombinant EPO stimulate the hormone erythroferrone and corresponding changes in iron regulation. Altitude doesn\u2019t result in the same iron profile.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;But my dream is that EPO manufacturers put a tracer in their drugs,&#8221; says Robach, &#8220;but I can\u2019t see the likes of Novo Nordisk doing that. Their drugs are for therapeutic purposes. Understandably, sporting abuse isn\u2019t top of their concerns.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s clear that anti-doping faces two fundamental challenges: how do you detect a performance-boosting substance that has such a short half-life? And how do you separate a rider\u2019s legitimate adaptation to the mountains from an artificial attempt to recreate the same advantage? It\u2019s also clear that the battle against micro-dosing will not be won by one breakthrough test. Altitude, EPO and blood manipulation all exploit the same physiological pathway: increasing oxygen delivery through red blood cells. As detection evolves, the future may lie in looking beyond traditional blood markers towards plasma volume, iron metabolism and omics. Until then, the flaws of micro-dosing mean athlete welfare will play second fiddle to the credibility of the anti-doping system.<\/p>\n<\/div>\n<div class=\"block mb-5\" id=\"articleTag\" data-component-name=\"PostArticleLinks\" data-nosnippet data-mrf-recirculation=\"post-article-links\">\n<div class=\"border-b border-b-black border-solid py-2.5 text-black font-bold uppercase\">TOPICS<\/div>\n<nav class=\"py-2.5 flex gap-2.5 flex-wrap\" data-analytics-id=\"article-tag\" data-mrf-recirculation=\"article-tag\">\n<p>Premium Investigations<\/p>\n<p>Premium In-Depth Racing<\/p>\n<\/nav>\n<\/div>\n<div id=\"slice-container-authorBio-vXKsvXvQao2yRgTfSgw4w9\" class=\"slice-container slice-author-bio authorBio-vXKsvXvQao2yRgTfSgw4w9 slice-container-authorBio\">\n<div class=\"author author__default-layout author--separator\">\n<div class=\"author__header\">\n<div class=\"author__heading\">\n<div class=\"author__name\">James Witts<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<div class=\"relative max-w-[1070px] viafoura-twig-component mt-6 mx-4 lg:mx-0\" data-component-name=\"Viafoura:Comments\" data-nosnippet data-community-guidelines-text=\"&lt;p class=&apos;vfcustom-community-guidelines&apos;&gt;Please follow our &lt;a href=&quot;https:\/\/www.cyclingnews.com\/about\/#section-community-guidelines&quot; 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&#8211; 2022 Alpe d&#8217;Huez winner Tom Pidcock suffers badly on same ascent in 2026 Tour de France<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">3<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>&#8216;With all those people, something was bound to go wrong&#8217; &#8211; Remco Evenepoel strengthens his Tour de France position despite being blocked by fans and motorbikes on Alpe d&#8217;Huez<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">4<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>Sepp Kuss still aiming for Tour de France stage win on Alpe d&#8217;Huez after being denied by Tadej Poga\u010dar on stage 19<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">5<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>&#8216;We&#8217;ve kept motivating each other&#8217; &#8211; Isaac del Toro tightens grip on Tour de France podium as UAE Team Emirates bounce back from illness<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<article class=\"page-content-onecol flex-1\nnews-article article\n\"><\/p>\n<div class=\"widget-area-group widget-area-group-2col flex flex-wrap box-border\">\n<div id=\"widgetArea16\" class=\"widget-area basis-full md:basis-2\/3 widget-area-g-md-vp-2-3 widget-area-g-lg-vp-2-3 widget-area-g-xl-vp-2-3 page-widget-area-16\">\n<div data-widget-type=\"hero\" id=\"hero\" class=\"clear-both widget widget-hero widget-hero widget-hero-hero widget-hero widget-hero-fter-news\">\n<div class=\"news-article\">\n<header data-component-name=\"Article:Hero\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumbs\">\n<ol>\n<li>\nPro Cycling\n<\/li>\n<li>\nRules\n<\/li>\n<li>\nDoping\n<\/li>\n<\/ol>\n<\/nav>\n<h1>An altitude alibi: Does cycling&#8217;s anti-doping system have a major loophole?<\/h1>\n<div class=\"kiosq-member-label\" data-component-name=\"Article:Hero:KiosqPaywallLabels\"><span class=\"kiosq-member-label-text\"><br \/>\nMEMBER EXCLUSIVE<br \/>\n<\/span><\/div>\n<div class=\"byline-social\">\n<div class=\"vds-byline-block flex flex-row flex-nowrap my-1.5 gap-2 text-left items-start justify-center mx-auto max-sm:text-center max-sm:items-center\" data-component-name=\"Article:BylineBlock\">\n<p>Features<\/p>\n<div class=\"my-auto vds-simple-byline\"><span class=\"inline-block vds-author\"><br \/>\nBy<br \/>\nJames Witts <\/span><\/p>\n<div class=\"flex gap-1 vds-byline-with-avatar__meta max-sm:justify-center\"><span class=\"vds-date block font-normal tracking-normal normal-case text-xs\"><br \/>\nPublished<br \/>\n<time data-component-name=\"UI:DateTime\" datetime=\"2026-07-25T07:12:47Z\" class=\"relative-date\"><br \/>\n25 July 2026<br \/>\n<\/time><\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"strapline\">Cycling&#8217;s recent nighttime anti-doping wake-up calls highlighted concerns that micro-dosing is fuelling an ever-accelerating peloton. Further concerns arise from the similar biological footprints left by hypoxic adaptation and artificial EPO. Is modern-day cycling as clean as we hoped? Cyclingnews investigates\u2026<\/p>\n<\/div>\n<aside class=\"text-gray-700 flex items-center mx-0 my-5 p-0 justify-center text-center\" id=\"affiliate-disclaimer\" data-component-name=\"AffiliateDisclaimer\" data-hawk-message=\"Affiliate disclaimer removed because hawk deemed there are no affiliate links on this page\">\n<p class=\"text-[color:var(--affiliate-disclaimer--text-color,inherit)] mb-2 text-[length:var(--affiliate-disclaimer--font-size,0.75rem)] leading-[18px] md:text-[13px] [&amp;&gt;a]:text-inherit [&amp;&gt;a]:underline\">\nWhen you purchase through links on our site, we may earn an affiliate commission. Here\u2019s how it works.\n<\/p>\n<\/aside>\n<\/header>\n<\/div>\n<\/div>\n<div data-widget-type=\"contentparsed\" id=\"content\" class=\"clear-both widget widget-contentparsed widget-content widget-contentparsed-content widget-content-parsed widget-content-parsed-content_document \">\n<div class=\"wcp-item-content\">\n<section class=\"content-wrapper\">\n<div class=\"box less-space hero-image-wrapper\">\n<figure class=\"mb-0\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1600-80.jpg.webp 1600w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-750-80.jpg.webp 750w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><figcaption class=\"font-article-copy text-(--image--text--color) font-article-copy mt-2\"><span class=\"caption-text font-article-copy\">Altitude training only makes the jobs of anti-doping authorities harder given the similar biological footprints of hypoxic adaptation and artificial EPO<\/span><span class=\"credit font-article-copy\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<\/div>\n<div id=\"article-body\" class=\"text-copy bodyCopy auto paywall-locker\">\n<div data-analytics-id=\"utility-bar\" id=\"utility-bar\" class=\"font-ui-heading flex justify-between items-center py-2 border-t border-b border-gray-300 border-solid mb-5 mx-auto\" data-component-name=\"UtilityBar\" data-mrf-recirculation=\"utility-bar\">\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div data-component-name=\"Social:Dropdown\" role=\"menu\" id=\"utilitybar__dropdown--share\" aria-labelledby=\"utilitybar__button--share\" class=\"absolute left-0 top-full w-44 bg-white rounded-md shadow-md border border-neutral-200 z-[9996] list-none m-0 py-2 px-3 border-solid\">\n<ul class=\"m-0!\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Facebook<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>X<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Pinterest<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Email<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-share-this-article\" role=\"tooltip\" aria-hidden=\"true\">\nShare this article\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\"><span class=\"ml-1 inline-flex h-5 px-2 shrink-0 items-center justify-center self-center overflow-hidden whitespace-nowrap rounded-[10px] bg-primary-500 text-[11px] leading-none font-ui-heading font-semibold text-white\">0<\/span><\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-join-the-conversation\" role=\"tooltip\" aria-hidden=\"true\">\nJoin the conversation\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<p>Follow us<\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-add-us-as-a-preferred-source-on-google\" role=\"tooltip\" aria-hidden=\"true\">\nAdd us as a preferred source on Google\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-subscribe-to-our-newsletter\" role=\"tooltip\" aria-hidden=\"true\">\nSubscribe to our newsletter\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a\">As I write this, online is abuzz with Jonas Vingegaard crashing out of this year\u2019s Tour de France. The potential cause? Being awoken at 2 a.m. for an anti-doping test. Tadej Poga\u010dar, wrote <em>The Guardian<\/em>\u2019s Jeremy Whittle, said the disturbance could &#8220;be a small percentage in why he crashed because he probably didn\u2019t sleep good&#8221;, adding: &#8220;I know how it feels. They woke me up at five in the morning also, but at least I got my deep sleep. It\u2019s better than if they come at two.&#8221; Why were the Dane and Slovenian woken between 11 p.m. and 6 a.m., which is uncommon from the International Testing Agency (ITA), who roll out the anti-doping programme on behalf of the UCI? No official reasons have been given, and being selected for a test, including out of hours, is a standard part of anti-doping controls, and does not imply any suspicion of, or wrongdoing by, the riders concerned.<\/p>\n<p>However, when WADA first permitted nighttime testing across all its sports in 2015, there was a reason for it. The Cycling Independent Reform Commission (CIRC) stated in 2015 that &#8220;the absence of nighttime testing [was] a weakness in the current system&#8221;, specifically regarding the issue of micro-dosing.<\/p>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a-2\" aria-hidden=\"true\" class=\"kiosq-b\">Here, we delve deep into micro-dosing\u2019s detection challenge, made harder by the issue of altitude\u2026<\/p>\n<h2 id=\"the-science-says-no-3\" aria-hidden=\"true\" class=\"kiosq-b\">The science says \u2018no\u2019<\/h2>\n<p id=\"elk-2c91627e-8688-11f1-8223-458f0831d746\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;In 2010, Carsten Lundby and I had a <u>study<\/u> published [in the European Journal of Applied Physiology] where we sent anonymous doped EPO [the blood-booster erythropoietin] samples to anti-doping laboratories in Cologne and Lausanne to see if the results would come back positive. The results were poor. Not because the technicians are poor, but the gaps in the test, especially the passport.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The words of Dr Paul Robach, who works in the department of biomedical research at the National School of Mountain Sports, Chamonix, France. Robach is a world-leading authority on the blood changes fuelled by either the needle or a mountain.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Back to his eye-opening 2010 research. Half of the subjects who were injected with a significant amount of EPO before moving into the micro-dosing maintenance phase tested negative. Concerning. The World Anti-Doping Agency would rightly counter that the sensitivity of doping tests has improved in the intervening 16 years. Still, in my new book <em>Dope<\/em> it became clear that the micro-dosing shortcomings remained, one of the major flaws being rapidly flushed-out markers.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a3bc-873f-11f1-8dcc-933486d78dbe\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The ITA carried out several nighttime tests at the Tour de France recently <\/span><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<p id=\"elk-c7c3a42a-873f-11f1-80fc-c5204e01f89f\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;If a rider micro-dosed EPO at 11 p.m. and the doping control officer tested them at six the next morning, they\u2019d catch them with a direct blood test,&#8221; says Robach. &#8220;But the chances would be lower with the passport. It\u2019s because EPO has a short half-life of a few hours.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A direct doping test looks for a prohibited substance or its metabolites in an athlete\u2019s urine or blood, providing evidence that a banned drug has been used. The blood test doesn\u2019t search for specific substances. Instead, it tracks an athlete\u2019s blood markers over time and flags up unusual changes that may indicate doping. While direct tests aim to catch the substance itself, the blood passport is designed to detect the lasting biological effects of doping.<\/p>\n<h2 id=\"in-search-of-more-oxygen-3\" aria-hidden=\"true\" class=\"kiosq-b\">In search of more oxygen<\/h2>\n<p id=\"elk-2c91636e-8688-11f1-a262-a789e4d8a7c0\" aria-hidden=\"true\" class=\"kiosq-b\">Ultimately, no intelligence agency will communicate the reasons behind targeted or nocturnal testing. But the nighttime testing at the Tour does highlight a limitation of anti-doping procedures when it comes to micro-doping, which is exacerbated when trying to unpick the physiological changes accrued from synthetic EPO compared to altitude-stimulated EPO.<\/p>\n<div class=\"fancy-box kiosq-b\" id=\"elk-e2f7bdcc-87f7-11f1-b66b-2d5e5a6bb950\" aria-hidden=\"true\">\n<div class=\"fancy_box-title\">More features like this&#8230;<\/div>\n<div class=\"fancy_box_body\">\n<figure class=\"van-image-figure \">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-2560-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<ul>\n<li><strong>What to know about Tour de France nighttime testing \u2013 The rules, the results timeline, the ITA, reactions and more explained<\/strong><\/li>\n<li><strong>&#8216;Nowhere else would we accept that level of surveillance&#8217; \u2013 Between Whereabouts, nighttime testing and &#8216;clean anxiety&#8217;, is the anti-doping system in need of reform?<\/strong><\/li>\n<li><strong>&#8216;It\u2019s a wild west of doping activity&#8217; &#8211; How cycling&#8217;s amateur scene has become the epicentre for doping<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"elk-e2f7be44-87f7-11f1-b980-e5729c83d50e\" aria-hidden=\"true\" class=\"kiosq-b\">Which is perhaps not surprising, as the aim of each intervention is the same: to boost red blood cells, meaning the rider can tap into more oxygen to fuel working muscles. Achieving that goal by injection is prohibited. Heading high and forcing the oxygen-starved body to generate more EPO to create more red blood cells isn\u2019t.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A <u>2022 paper<\/u> by Jonas Saugy highlighted the problem, the researcher revealing that an athlete\u2019s blood profile when micro-dosing was &#8220;hardly distinguishable from those identified after hypoxic exposure&#8221; without doping.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The similar blood profiles included haemoglobin mass, which is the total amount of haemoglobin (oxygen carrier) in a rider\u2019s red blood cells. There\u2019s a tight relationship between VO2 max and haemoglobin mass, with research revealing that a 1g increase in haemoglobin mass can increase VO2 max by around 4ml\/min\/kg. As VO2 max is one of the limiting factors when it comes to an endurance sport like road cycling, the benefits are clear.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Further separate research highlights similar benefits enjoyed from micro-dosing and training at altitude. A <u>2024 study<\/u> revealed that injecting nine IU\/kg of bodyweight of EPO three times weekly over four weeks boosted endurance by up to 6% in trained athletes, which would equate to around 2% in elites, who have less room to grow.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">As for altitude training, a 2016 meta-analysis of elite athletes reported an average VO2max increase of around 2%, so similar to those micro-dosing results.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a4a2-873f-11f1-8610-9328df48c900\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">Tenerife and its iconic Teide volcano is a popular altitude training location for WorldTour cyclists <\/span><span class=\"credit\">(Image credit: Nicolas Economou\/NurPhoto via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"the-variability-of-altitude-training-3\" aria-hidden=\"true\" class=\"kiosq-b\">The variability of altitude training<\/h2>\n<p id=\"elk-2c9164a4-8688-11f1-86ad-9925d1ea9434\" aria-hidden=\"true\" class=\"kiosq-b\">It begs the question: why cheat when the legal means (altitude) deliver similar gains? &#8220;A rider\u2019s response to altitude training is highly variable,&#8221; says Robach. &#8220;We have an ongoing study that shows our group\u2019s haematological response to one year at high altitude varies from 1% to 50%.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach\u2019s results mirror earlier <u>research<\/u> charting how elite endurance athletes respond to altitude training camps and whether they can be reliably classified as &#8220;responders&#8221; or &#8220;non-responders.&#8221; Researchers analysed 82 altitude camps involving 59 athletes and measured changes in haemoglobin mass.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Haemoglobin mass increased after 56% of camps, rising to 65% when athletes trained above 2,000 metres (we\u2019ll come back to that height-related stimulus shortly). However, responses varied greatly both between athletes and within the same athlete across different camps.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;From the 15 athletes who participated in altitude training camps at least twice, 27% always had positive haemoglobin responses; 60% both positive and negative responses; and 13% only negative responses.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">In other words, altitude training doesn\u2019t always work. Worse than that for the rider and support staff, it might work for a rider at one camp but not at the next.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologist Inigo Mujika would suggest this variability\u2019s down to sidestepping the five I\u2019s. These are: Iron \u2013 inadequate iron intake may compromise adaptations to altitude; Intake \u2013 low energy diets don\u2019t support adaptations; Injury \u2013 prolonged inflammatory responses associated with serious soft tissue injury can interfere with adaptation; Illness \u2013 viral and bacterial infections do the same; and Intensity \u2013 excessive workload at the start of an altitude camp can promote excessive fatigue and, again, impair adaptation.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even with the best-laid plans, results from altitude training remain inconsistent. One reason why is limitations in how low each rider can go\u2026<\/p>\n<h2 id=\"triggering-hif-1-3\" aria-hidden=\"true\" class=\"kiosq-b\">Triggering HIF-1<\/h2>\n<p id=\"elk-2c91658a-8688-11f1-a342-df9d5ddc3877\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Ultimately, optimising altitude training is around the amount that you can safely reduce your oxygen saturation level [SpO2], which you can measure with a pulse oximeter on the tip of your finger,&#8221; says top coach and sport scientist Dan Healey, who formerly worked with Alberto Contador at Tinkoff-Saxo. A normal range at sea level is around 95 to 100%. When you train at altitude, the thinner air naturally means that [it] usually drops. &#8220;You\u2019ll aim for the rider\u2019s SpO2 to drop to 90 and into the 80s. The sweet spot for optimum EPO production is probably in the 70s.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Healey says you need that rarefied stimulus to trigger a protein complex called hypoxia-inducible factor-1 alpha (HIF-1 alpha). &#8220;Every day, HIF-1 alpha is produced but killed. It\u2019s a really complex mechanism. But when you go to altitude, it\u2019s free to do its thing. HIF-1 alpha will join with HIF-2. That\u2019s when you get EPO production and why teams spend a lot of money on altitude camps. Basically, they\u2019re spending top dollar to trigger HIF-1.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even when ticking those five \u2018I\u2019 boxes of Mujika\u2019s, how much HIF-1 alpha is triggered can vary greatly. In <em>Dope<\/em>, Rory Townsend told me that no matter what he does, his SpO2 levels remain well into the 90s. He\u2019s seemingly a staunch non-responder. That said, he\u2019s never hit the lofty heights of Healey\u2019s recent research.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;The sweet spot for triggering HIF-1 is around 5,000m,&#8221; he says. &#8220;You\u2019ll need to do it in really short doses of extreme hypoxia \u2013 so SpO2 in the 70s for accelerated EPO release \u2013 though you must monitor the rider closely and ensure things are done safely.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\"><em>Cyclingnews <\/em>reiterates that this type of training should only be carried out under the supervision of expert medical guidance.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach agrees that adding a little more certainty from altitude training might require going higher than the 2-2,500m that most teams peak at. &#8220;But many coaches are concerned if they go too high the riders will be too fatigued or not sleep. I think it\u2019d be okay at 3-3,500m. But 5,000m? That\u2019s exploratory and yet to be scientifically proven.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologists and sports scientists love nothing more than consistency. That their research and applied practice delivers gains time and time again. It\u2019s repeatable. That\u2019s anathema to altitude training. Sometimes it works, sometimes it doesn\u2019t. But with micro-dosing EPO? &#8220;Ultimately, you\u2019ll have a higher chance of consistently boosting your haemoglobin mass with EPO than altitude,&#8221; says Robach. &#8220;Altitude training is complicated.&#8221;<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a51a-873f-11f1-8f01-bfb38d44e5f5\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The biological footprint similarities between hypoxic adaptation and artificial EPO make the ITA&#8217;s job even more challenging <\/span><span class=\"credit\">(Image credit: THOMAS SAMSON\/AFP via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"what-of-the-future-3\" aria-hidden=\"true\" class=\"kiosq-b\">What of the future?<\/h2>\n<p id=\"elk-2c91667a-8688-11f1-a5fa-298b66ae223f\" aria-hidden=\"true\" class=\"kiosq-b\">So, there are compelling reasons why a rider might micro-dose, especially at altitude, as there\u2019s evidence that you enjoy a double boost, again without testing negative unless tested close to injection time.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s also not solely about micro-dosing EPO. Both infusing your own blood and injecting human growth hormone at nominal levels deliver a physiological advantage and a small detection window.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Which is why a credible anti-doping system can\u2019t rely so much on the biological blood passport. Sidestepping the cost implications of research and implementing a new test that\u2019s legally watertight, are there new tests on the horizon that could actually solve the micro-dosing and altitude riddle?<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Possibly. While much of the focus has been on changes in reticulocytes and other red blood cell markers, an alternative approach may be to examine shifts in plasma volume. One of the primary physiological responses to altitude exposure is a reduction in plasma volume \u2013 the liquid component of blood \u2013 which can influence many of the variables monitored by the biological passport.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">WADA has already explored machine-learning models that estimate an athlete\u2019s expected plasma volume over time, using artificial intelligence to distinguish normal physiological variation from patterns consistent with doping. Although this would require an additional blood measurement, incorporating plasma volume estimates could help differentiate the effects of altitude exposure from those of EPO micro-dosing.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;There\u2019s also great potential in the area of omics,&#8221; says Robach. This taps into the ongoing work of Professor Yannis Pitsiladis, a leading advocate for applying omics technologies \u2013 genomics, transcriptomics, proteomics and metabolomics \u2013 to anti-doping. By analysing thousands of biological markers simultaneously, these approaches could reveal subtle signatures of EPO use, blood manipulation and other forms of doping, potentially improving detection.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Exploring iron metabolism could pay off, too,&#8221; adds Robach, who along with colleagues has shown that even low doses of recombinant EPO stimulate the hormone erythroferrone and corresponding changes in iron regulation. Altitude doesn\u2019t result in the same iron profile.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;But my dream is that EPO manufacturers put a tracer in their drugs,&#8221; says Robach, &#8220;but I can\u2019t see the likes of Novo Nordisk doing that. Their drugs are for therapeutic purposes. Understandably, sporting abuse isn\u2019t top of their concerns.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s clear that anti-doping faces two fundamental challenges: how do you detect a performance-boosting substance that has such a short half-life? And how do you separate a rider\u2019s legitimate adaptation to the mountains from an artificial attempt to recreate the same advantage? It\u2019s also clear that the battle against micro-dosing will not be won by one breakthrough test. Altitude, EPO and blood manipulation all exploit the same physiological pathway: increasing oxygen delivery through red blood cells. As detection evolves, the future may lie in looking beyond traditional blood markers towards plasma volume, iron metabolism and omics. Until then, the flaws of micro-dosing mean athlete welfare will play second fiddle to the credibility of the anti-doping system.<\/p>\n<\/div>\n<div class=\"block mb-5\" id=\"articleTag\" data-component-name=\"PostArticleLinks\" data-nosnippet data-mrf-recirculation=\"post-article-links\">\n<div class=\"border-b border-b-black border-solid py-2.5 text-black font-bold uppercase\">TOPICS<\/div>\n<nav class=\"py-2.5 flex gap-2.5 flex-wrap\" data-analytics-id=\"article-tag\" data-mrf-recirculation=\"article-tag\">\n<p>Premium Investigations<\/p>\n<p>Premium In-Depth Racing<\/p>\n<\/nav>\n<\/div>\n<div id=\"slice-container-authorBio-vXKsvXvQao2yRgTfSgw4w9\" class=\"slice-container slice-author-bio authorBio-vXKsvXvQao2yRgTfSgw4w9 slice-container-authorBio\">\n<div class=\"author author__default-layout author--separator\">\n<div class=\"author__header\">\n<div class=\"author__heading\">\n<div class=\"author__name\">James Witts<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n<div class=\"relative max-w-[1070px] viafoura-twig-component mt-6 mx-4 lg:mx-0\" data-component-name=\"Viafoura:Comments\" data-nosnippet data-community-guidelines-text=\"&lt;p class=&apos;vfcustom-community-guidelines&apos;&gt;Please follow our &lt;a href=&quot;https:\/\/www.cyclingnews.com\/about\/#section-community-guidelines&quot; 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&#8211; 2022 Alpe d&#8217;Huez winner Tom Pidcock suffers badly on same ascent in 2026 Tour de France<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">3<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>&#8216;With all those people, something was bound to go wrong&#8217; &#8211; Remco Evenepoel strengthens his Tour de France position despite being blocked by fans and motorbikes on Alpe d&#8217;Huez<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">4<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>Sepp Kuss still aiming for Tour de France stage win on Alpe d&#8217;Huez after being denied by Tadej Poga\u010dar on stage 19<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"popular-box__article-list\">\n<div class=\"popular-box__article-list__container\">\n<div class=\"popular-box__article-list__content\">\n<div class=\"popular-box__article-list__number-text\">5<\/div>\n<div class=\"popular-box__article-list__heading\">\n<p>&#8216;We&#8217;ve kept motivating each other&#8217; &#8211; Isaac del Toro tightens grip on Tour de France podium as UAE Team Emirates bounce back from illness<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ol>\n<\/section>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/article>\n<div class=\"news-article\">\n<header data-component-name=\"Article:Hero\">\n<nav class=\"breadcrumb\" aria-label=\"Breadcrumbs\">\n<ol>\n<li>\nPro Cycling\n<\/li>\n<li>\nRules\n<\/li>\n<li>\nDoping\n<\/li>\n<\/ol>\n<\/nav>\n<h1>An altitude alibi: Does cycling&#8217;s anti-doping system have a major loophole?<\/h1>\n<div class=\"kiosq-member-label\" data-component-name=\"Article:Hero:KiosqPaywallLabels\"><span class=\"kiosq-member-label-text\"><br \/>\nMEMBER EXCLUSIVE<br \/>\n<\/span><\/div>\n<div class=\"byline-social\">\n<div class=\"vds-byline-block flex flex-row flex-nowrap my-1.5 gap-2 text-left items-start justify-center mx-auto max-sm:text-center max-sm:items-center\" data-component-name=\"Article:BylineBlock\">\n<p>Features<\/p>\n<div class=\"my-auto vds-simple-byline\"><span class=\"inline-block vds-author\"><br \/>\nBy<br \/>\nJames Witts <\/span><\/p>\n<div class=\"flex gap-1 vds-byline-with-avatar__meta max-sm:justify-center\"><span class=\"vds-date block font-normal tracking-normal normal-case text-xs\"><br \/>\nPublished<br \/>\n<time data-component-name=\"UI:DateTime\" datetime=\"2026-07-25T07:12:47Z\" class=\"relative-date\"><br \/>\n25 July 2026<br \/>\n<\/time><\/span><\/div>\n<\/div>\n<\/div>\n<p class=\"strapline\">Cycling&#8217;s recent nighttime anti-doping wake-up calls highlighted concerns that micro-dosing is fuelling an ever-accelerating peloton. Further concerns arise from the similar biological footprints left by hypoxic adaptation and artificial EPO. Is modern-day cycling as clean as we hoped? Cyclingnews investigates\u2026<\/p>\n<\/div>\n<aside class=\"text-gray-700 flex items-center mx-0 my-5 p-0 justify-center text-center\" id=\"affiliate-disclaimer\" data-component-name=\"AffiliateDisclaimer\" data-hawk-message=\"Affiliate disclaimer removed because hawk deemed there are no affiliate links on this page\">\n<p class=\"text-[color:var(--affiliate-disclaimer--text-color,inherit)] mb-2 text-[length:var(--affiliate-disclaimer--font-size,0.75rem)] leading-[18px] md:text-[13px] [&amp;&gt;a]:text-inherit [&amp;&gt;a]:underline\">\nWhen you purchase through links on our site, we may earn an affiliate commission. Here\u2019s how it works.\n<\/p>\n<\/aside>\n<\/header>\n<\/div>\n<div id=\"article-body\" class=\"text-copy bodyCopy auto paywall-locker\">\n<div data-analytics-id=\"utility-bar\" id=\"utility-bar\" class=\"font-ui-heading flex justify-between items-center py-2 border-t border-b border-gray-300 border-solid mb-5 mx-auto\" data-component-name=\"UtilityBar\" data-mrf-recirculation=\"utility-bar\">\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div data-component-name=\"Social:Dropdown\" role=\"menu\" id=\"utilitybar__dropdown--share\" aria-labelledby=\"utilitybar__button--share\" class=\"absolute left-0 top-full w-44 bg-white rounded-md shadow-md border border-neutral-200 z-[9996] list-none m-0 py-2 px-3 border-solid\">\n<ul class=\"m-0!\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Facebook<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>X<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Pinterest<\/p>\n<\/li>\n<li class=\"!p-0 !m-0 list-none border-b border-gray-200 border-solid\">\n<p>Email<\/p>\n<\/li>\n<\/ul>\n<\/div>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-share-this-article\" role=\"tooltip\" aria-hidden=\"true\">\nShare this article\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\"><span class=\"ml-1 inline-flex h-5 px-2 shrink-0 items-center justify-center self-center overflow-hidden whitespace-nowrap rounded-[10px] bg-primary-500 text-[11px] leading-none font-ui-heading font-semibold text-white\">0<\/span><\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-join-the-conversation\" role=\"tooltip\" aria-hidden=\"true\">\nJoin the conversation\n<\/div>\n<\/div>\n<\/div>\n<div class=\"flex gap-2 text-[#333] subcontainer\">\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<p>Follow us<\/p>\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-add-us-as-a-preferred-source-on-google\" role=\"tooltip\" aria-hidden=\"true\">\nAdd us as a preferred source on Google\n<\/div>\n<\/div>\n<div class=\"relative tooltip-container\" role=\"tooltip\">\n<div class=\"font-ui-heading max-sm:hidden tooltip absolute left-1\/2 bg-gray-900 text-white text-xs leading-none px-3 py-1.5 rounded-md z-[10001] whitespace-nowrap\" id=\"tooltip-subscribe-to-our-newsletter\" role=\"tooltip\" aria-hidden=\"true\">\nSubscribe to our newsletter\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a\">As I write this, online is abuzz with Jonas Vingegaard crashing out of this year\u2019s Tour de France. The potential cause? Being awoken at 2 a.m. for an anti-doping test. Tadej Poga\u010dar, wrote <em>The Guardian<\/em>\u2019s Jeremy Whittle, said the disturbance could &#8220;be a small percentage in why he crashed because he probably didn\u2019t sleep good&#8221;, adding: &#8220;I know how it feels. They woke me up at five in the morning also, but at least I got my deep sleep. It\u2019s better than if they come at two.&#8221; Why were the Dane and Slovenian woken between 11 p.m. and 6 a.m., which is uncommon from the International Testing Agency (ITA), who roll out the anti-doping programme on behalf of the UCI? No official reasons have been given, and being selected for a test, including out of hours, is a standard part of anti-doping controls, and does not imply any suspicion of, or wrongdoing by, the riders concerned.<\/p>\n<p>However, when WADA first permitted nighttime testing across all its sports in 2015, there was a reason for it. The Cycling Independent Reform Commission (CIRC) stated in 2015 that &#8220;the absence of nighttime testing [was] a weakness in the current system&#8221;, specifically regarding the issue of micro-dosing.<\/p>\n<p id=\"elk-2c9160ee-8688-11f1-94af-4bd798a0490a-2\" aria-hidden=\"true\" class=\"kiosq-b\">Here, we delve deep into micro-dosing\u2019s detection challenge, made harder by the issue of altitude\u2026<\/p>\n<h2 id=\"the-science-says-no-3\" aria-hidden=\"true\" class=\"kiosq-b\">The science says \u2018no\u2019<\/h2>\n<p id=\"elk-2c91627e-8688-11f1-8223-458f0831d746\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;In 2010, Carsten Lundby and I had a <u>study<\/u> published [in the European Journal of Applied Physiology] where we sent anonymous doped EPO [the blood-booster erythropoietin] samples to anti-doping laboratories in Cologne and Lausanne to see if the results would come back positive. The results were poor. Not because the technicians are poor, but the gaps in the test, especially the passport.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The words of Dr Paul Robach, who works in the department of biomedical research at the National School of Mountain Sports, Chamonix, France. Robach is a world-leading authority on the blood changes fuelled by either the needle or a mountain.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Back to his eye-opening 2010 research. Half of the subjects who were injected with a significant amount of EPO before moving into the micro-dosing maintenance phase tested negative. Concerning. The World Anti-Doping Agency would rightly counter that the sensitivity of doping tests has improved in the intervening 16 years. Still, in my new book <em>Dope<\/em> it became clear that the micro-dosing shortcomings remained, one of the major flaws being rapidly flushed-out markers.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a3bc-873f-11f1-8dcc-933486d78dbe\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/6ykzekFUcErvsV3h6KstsX-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The ITA carried out several nighttime tests at the Tour de France recently <\/span><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<p id=\"elk-c7c3a42a-873f-11f1-80fc-c5204e01f89f\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;If a rider micro-dosed EPO at 11 p.m. and the doping control officer tested them at six the next morning, they\u2019d catch them with a direct blood test,&#8221; says Robach. &#8220;But the chances would be lower with the passport. It\u2019s because EPO has a short half-life of a few hours.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A direct doping test looks for a prohibited substance or its metabolites in an athlete\u2019s urine or blood, providing evidence that a banned drug has been used. The blood test doesn\u2019t search for specific substances. Instead, it tracks an athlete\u2019s blood markers over time and flags up unusual changes that may indicate doping. While direct tests aim to catch the substance itself, the blood passport is designed to detect the lasting biological effects of doping.<\/p>\n<h2 id=\"in-search-of-more-oxygen-3\" aria-hidden=\"true\" class=\"kiosq-b\">In search of more oxygen<\/h2>\n<p id=\"elk-2c91636e-8688-11f1-a262-a789e4d8a7c0\" aria-hidden=\"true\" class=\"kiosq-b\">Ultimately, no intelligence agency will communicate the reasons behind targeted or nocturnal testing. But the nighttime testing at the Tour does highlight a limitation of anti-doping procedures when it comes to micro-doping, which is exacerbated when trying to unpick the physiological changes accrued from synthetic EPO compared to altitude-stimulated EPO.<\/p>\n<div class=\"fancy-box kiosq-b\" id=\"elk-e2f7bdcc-87f7-11f1-b66b-2d5e5a6bb950\" aria-hidden=\"true\">\n<div class=\"fancy_box-title\">More features like this&#8230;<\/div>\n<div class=\"fancy_box_body\">\n<figure class=\"van-image-figure \">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-2560-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/MVMyQy4j8kc4GNYaZbNDvN-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class><span class=\"credit\">(Image credit: Getty Images)<\/span><\/figcaption><\/figure>\n<ul>\n<li><strong>What to know about Tour de France nighttime testing \u2013 The rules, the results timeline, the ITA, reactions and more explained<\/strong><\/li>\n<li><strong>&#8216;Nowhere else would we accept that level of surveillance&#8217; \u2013 Between Whereabouts, nighttime testing and &#8216;clean anxiety&#8217;, is the anti-doping system in need of reform?<\/strong><\/li>\n<li><strong>&#8216;It\u2019s a wild west of doping activity&#8217; &#8211; How cycling&#8217;s amateur scene has become the epicentre for doping<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"elk-e2f7be44-87f7-11f1-b980-e5729c83d50e\" aria-hidden=\"true\" class=\"kiosq-b\">Which is perhaps not surprising, as the aim of each intervention is the same: to boost red blood cells, meaning the rider can tap into more oxygen to fuel working muscles. Achieving that goal by injection is prohibited. Heading high and forcing the oxygen-starved body to generate more EPO to create more red blood cells isn\u2019t.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">A <u>2022 paper<\/u> by Jonas Saugy highlighted the problem, the researcher revealing that an athlete\u2019s blood profile when micro-dosing was &#8220;hardly distinguishable from those identified after hypoxic exposure&#8221; without doping.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">The similar blood profiles included haemoglobin mass, which is the total amount of haemoglobin (oxygen carrier) in a rider\u2019s red blood cells. There\u2019s a tight relationship between VO2 max and haemoglobin mass, with research revealing that a 1g increase in haemoglobin mass can increase VO2 max by around 4ml\/min\/kg. As VO2 max is one of the limiting factors when it comes to an endurance sport like road cycling, the benefits are clear.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Further separate research highlights similar benefits enjoyed from micro-dosing and training at altitude. A <u>2024 study<\/u> revealed that injecting nine IU\/kg of bodyweight of EPO three times weekly over four weeks boosted endurance by up to 6% in trained athletes, which would equate to around 2% in elites, who have less room to grow.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">As for altitude training, a 2016 meta-analysis of elite athletes reported an average VO2max increase of around 2%, so similar to those micro-dosing results.<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a4a2-873f-11f1-8610-9328df48c900\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/kc62n3c2rCuDgEWKAYxrDD-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">Tenerife and its iconic Teide volcano is a popular altitude training location for WorldTour cyclists <\/span><span class=\"credit\">(Image credit: Nicolas Economou\/NurPhoto via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"the-variability-of-altitude-training-3\" aria-hidden=\"true\" class=\"kiosq-b\">The variability of altitude training<\/h2>\n<p id=\"elk-2c9164a4-8688-11f1-86ad-9925d1ea9434\" aria-hidden=\"true\" class=\"kiosq-b\">It begs the question: why cheat when the legal means (altitude) deliver similar gains? &#8220;A rider\u2019s response to altitude training is highly variable,&#8221; says Robach. &#8220;We have an ongoing study that shows our group\u2019s haematological response to one year at high altitude varies from 1% to 50%.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach\u2019s results mirror earlier <u>research<\/u> charting how elite endurance athletes respond to altitude training camps and whether they can be reliably classified as &#8220;responders&#8221; or &#8220;non-responders.&#8221; Researchers analysed 82 altitude camps involving 59 athletes and measured changes in haemoglobin mass.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Haemoglobin mass increased after 56% of camps, rising to 65% when athletes trained above 2,000 metres (we\u2019ll come back to that height-related stimulus shortly). However, responses varied greatly both between athletes and within the same athlete across different camps.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;From the 15 athletes who participated in altitude training camps at least twice, 27% always had positive haemoglobin responses; 60% both positive and negative responses; and 13% only negative responses.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">In other words, altitude training doesn\u2019t always work. Worse than that for the rider and support staff, it might work for a rider at one camp but not at the next.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologist Inigo Mujika would suggest this variability\u2019s down to sidestepping the five I\u2019s. These are: Iron \u2013 inadequate iron intake may compromise adaptations to altitude; Intake \u2013 low energy diets don\u2019t support adaptations; Injury \u2013 prolonged inflammatory responses associated with serious soft tissue injury can interfere with adaptation; Illness \u2013 viral and bacterial infections do the same; and Intensity \u2013 excessive workload at the start of an altitude camp can promote excessive fatigue and, again, impair adaptation.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even with the best-laid plans, results from altitude training remain inconsistent. One reason why is limitations in how low each rider can go\u2026<\/p>\n<h2 id=\"triggering-hif-1-3\" aria-hidden=\"true\" class=\"kiosq-b\">Triggering HIF-1<\/h2>\n<p id=\"elk-2c91658a-8688-11f1-a342-df9d5ddc3877\" aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Ultimately, optimising altitude training is around the amount that you can safely reduce your oxygen saturation level [SpO2], which you can measure with a pulse oximeter on the tip of your finger,&#8221; says top coach and sport scientist Dan Healey, who formerly worked with Alberto Contador at Tinkoff-Saxo. A normal range at sea level is around 95 to 100%. When you train at altitude, the thinner air naturally means that [it] usually drops. &#8220;You\u2019ll aim for the rider\u2019s SpO2 to drop to 90 and into the 80s. The sweet spot for optimum EPO production is probably in the 70s.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Healey says you need that rarefied stimulus to trigger a protein complex called hypoxia-inducible factor-1 alpha (HIF-1 alpha). &#8220;Every day, HIF-1 alpha is produced but killed. It\u2019s a really complex mechanism. But when you go to altitude, it\u2019s free to do its thing. HIF-1 alpha will join with HIF-2. That\u2019s when you get EPO production and why teams spend a lot of money on altitude camps. Basically, they\u2019re spending top dollar to trigger HIF-1.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">But even when ticking those five \u2018I\u2019 boxes of Mujika\u2019s, how much HIF-1 alpha is triggered can vary greatly. In <em>Dope<\/em>, Rory Townsend told me that no matter what he does, his SpO2 levels remain well into the 90s. He\u2019s seemingly a staunch non-responder. That said, he\u2019s never hit the lofty heights of Healey\u2019s recent research.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;The sweet spot for triggering HIF-1 is around 5,000m,&#8221; he says. &#8220;You\u2019ll need to do it in really short doses of extreme hypoxia \u2013 so SpO2 in the 70s for accelerated EPO release \u2013 though you must monitor the rider closely and ensure things are done safely.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\"><em>Cyclingnews <\/em>reiterates that this type of training should only be carried out under the supervision of expert medical guidance.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Robach agrees that adding a little more certainty from altitude training might require going higher than the 2-2,500m that most teams peak at. &#8220;But many coaches are concerned if they go too high the riders will be too fatigued or not sleep. I think it\u2019d be okay at 3-3,500m. But 5,000m? That\u2019s exploratory and yet to be scientifically proven.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Exercise physiologists and sports scientists love nothing more than consistency. That their research and applied practice delivers gains time and time again. It\u2019s repeatable. That\u2019s anathema to altitude training. Sometimes it works, sometimes it doesn\u2019t. But with micro-dosing EPO? &#8220;Ultimately, you\u2019ll have a higher chance of consistently boosting your haemoglobin mass with EPO than altitude,&#8221; says Robach. &#8220;Altitude training is complicated.&#8221;<\/p>\n<figure class=\"van-image-figure full-width-layout kiosq-b\" data-bordeaux-image-check id=\"elk-c7c3a51a-873f-11f1-8f01-bfb38d44e5f5\" aria-hidden=\"true\">\n<div class=\"image-full-width-wrapper\">\n<div class=\"image-widthsetter\">\n<p class=\"vanilla-image-block\">\n<source type=\"image\/webp\" srcset=\"https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-2000-80.jpg.webp 2560w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1920-80.jpg.webp 1920w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1440-80.jpg.webp 1440w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1280-80.jpg.webp 1280w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1200-80.jpg.webp 1200w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-1024-80.jpg.webp 1024w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-970-80.jpg.webp 970w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-650-80.jpg.webp 650w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-480-80.jpg.webp 480w, https:\/\/cdn.mos.cms.futurecdn.net\/PxmgP7TnWCUTXGPcRmkgic-320-80.jpg.webp 320w\" sizes=\"100vw\" \/><\/p>\n<\/div>\n<\/div><figcaption class=\" full-width-layout\"><span class=\"caption-text\">The biological footprint similarities between hypoxic adaptation and artificial EPO make the ITA&#8217;s job even more challenging <\/span><span class=\"credit\">(Image credit: THOMAS SAMSON\/AFP via Getty Images)<\/span><\/figcaption><\/figure>\n<h2 id=\"what-of-the-future-3\" aria-hidden=\"true\" class=\"kiosq-b\">What of the future?<\/h2>\n<p id=\"elk-2c91667a-8688-11f1-a5fa-298b66ae223f\" aria-hidden=\"true\" class=\"kiosq-b\">So, there are compelling reasons why a rider might micro-dose, especially at altitude, as there\u2019s evidence that you enjoy a double boost, again without testing negative unless tested close to injection time.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s also not solely about micro-dosing EPO. Both infusing your own blood and injecting human growth hormone at nominal levels deliver a physiological advantage and a small detection window.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Which is why a credible anti-doping system can\u2019t rely so much on the biological blood passport. Sidestepping the cost implications of research and implementing a new test that\u2019s legally watertight, are there new tests on the horizon that could actually solve the micro-dosing and altitude riddle?<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">Possibly. While much of the focus has been on changes in reticulocytes and other red blood cell markers, an alternative approach may be to examine shifts in plasma volume. One of the primary physiological responses to altitude exposure is a reduction in plasma volume \u2013 the liquid component of blood \u2013 which can influence many of the variables monitored by the biological passport.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">WADA has already explored machine-learning models that estimate an athlete\u2019s expected plasma volume over time, using artificial intelligence to distinguish normal physiological variation from patterns consistent with doping. Although this would require an additional blood measurement, incorporating plasma volume estimates could help differentiate the effects of altitude exposure from those of EPO micro-dosing.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;There\u2019s also great potential in the area of omics,&#8221; says Robach. This taps into the ongoing work of Professor Yannis Pitsiladis, a leading advocate for applying omics technologies \u2013 genomics, transcriptomics, proteomics and metabolomics \u2013 to anti-doping. By analysing thousands of biological markers simultaneously, these approaches could reveal subtle signatures of EPO use, blood manipulation and other forms of doping, potentially improving detection.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;Exploring iron metabolism could pay off, too,&#8221; adds Robach, who along with colleagues has shown that even low doses of recombinant EPO stimulate the hormone erythroferrone and corresponding changes in iron regulation. Altitude doesn\u2019t result in the same iron profile.<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">&#8220;But my dream is that EPO manufacturers put a tracer in their drugs,&#8221; says Robach, &#8220;but I can\u2019t see the likes of Novo Nordisk doing that. Their drugs are for therapeutic purposes. Understandably, sporting abuse isn\u2019t top of their concerns.&#8221;<\/p>\n<p aria-hidden=\"true\" class=\"kiosq-b\">It\u2019s clear that anti-doping faces two fundamental challenges: how do you detect a performance-boosting substance that has such a short half-life? And how do you separate a rider\u2019s legitimate adaptation to the mountains from an artificial attempt to recreate the same advantage? It\u2019s also clear that the battle against micro-dosing will not be won by one breakthrough test. Altitude, EPO and blood manipulation all exploit the same physiological pathway: increasing oxygen delivery through red blood cells. As detection evolves, the future may lie in looking beyond traditional blood markers towards plasma volume, iron metabolism and omics. Until then, the flaws of micro-dosing mean athlete welfare will play second fiddle to the credibility of the anti-doping system.<\/p>\n<\/div>\n<p>[analyse_source url=&#8221;https:\/\/www.cyclingnews.com\/pro-cycling\/doping\/an-altitude-alibi-does-cyclings-anti-doping-system-have-a-major-loophole\/&#8221;]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[analyse_image type=&#8221;featured&#8221; src=&#8221;https:\/\/cdn.mos.cms.futurecdn.net\/6YKztgCxUP3MKzPH5tU736-2000-80.jpg&#8221;] Pro Cycling Rules Doping An altitude alibi: Does cycling&#8217;s anti-doping system have a major loophole? MEMBER EXCLUSIVE Features By James Witts Published 25 July 2026 Cycling&#8217;s recent nighttime anti-doping wake-up calls highlighted concerns that micro-dosing is fuelling an ever-accelerating peloton. Further concerns arise from the similar biological footprints left by hypoxic adaptation [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[226,68],"class_list":["post-2061372","post","type-post","status-publish","format-standard","hentry","category-politics","tag-crawlmanager","tag-cyclingnews-com"],"_links":{"self":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/2061372","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2061372"}],"version-history":[{"count":0,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/2061372\/revisions"}],"wp:attachment":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2061372"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2061372"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2061372"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}