{"id":2048809,"date":"2026-07-17T12:05:50","date_gmt":"2026-07-17T09:05:50","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=2048809"},"modified":"2026-07-17T12:05:50","modified_gmt":"2026-07-17T09:05:50","slug":"un-vaccin-experimental-pentru-prevenirea-cancerului-pancreatic-a-declansat-un-raspuns-imunitar-la-90","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=2048809","title":{"rendered":"Un vaccin experimental pentru prevenirea cancerului pancreatic a declan\u0219at un r\u0103spuns imunitar la 90%&#8230;"},"content":{"rendered":"<p>[analyse_image type=&#8221;featured&#8221; src=&#8221;https:\/\/cdn.adh.reperio.news\/image-f\/fa6f780b-0f0f-4a6d-aa50-fc0d97010c1d\/index.jpeg?p=f%3Djpeg%26w%3D1200%26h%3D630%26r%3Dcover&#8221;]<\/p>\n<article class=\"svelte-x63bga\">\n<nav>\n<ul class=\"breadcrump svelte-1pk9a69\">\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/\" title=\"Adev\u0103rul\" class=\"svelte-1pk9a69\">Home<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\" class=\"svelte-1pk9a69\">Stil de via\u021b\u0103<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\/stiinta\" class=\"svelte-1pk9a69\">\u0218tiin\u021b\u0103<\/a><\/li>\n<li class=\"svelte-1pk9a69\"><a href=\"https:\/\/adevarul.ro\/stil-de-viata\/stiinta\/un-vaccin-experimental-pentru-prevenirea-2543925.html\" class=\"svelte-1pk9a69\">Un vaccin experimental pentru prevenirea cancerului pancreatic a declan\u0219at un r\u0103spuns imunitar la 90% dintre subiec\u021bi<\/a><\/li>\n<\/ul>\n<\/nav>\n<p><main class=\"svelte-x63bga\"><\/p>\n<p>Un vaccin experimental care \u021binte\u0219te muta\u021biile genei KRAS a declan\u0219at un r\u0103spuns imunitar puternic la 90% dintre participan\u021bii cu risc ridicat de cancer pancreatic.<\/p>\n<div class=\"container-image  svelte-1xbw4f3\"><source type=\"image\/webp\" srcset=\"https:\/\/cdn.adh.reperio.news\/image-f\/fa6f780b-0f0f-4a6d-aa50-fc0d97010c1d\/index.jpeg?p=a%3D1%26co%3D1.05%26w%3D1400%26h%3D750%26r%3Dcontain%26f%3Dwebp 1400w\" media=\"(min-width: 1400px)\" \/><\/p>\n<div class=\"caption\">Vaccinul experimental \u021binte\u0219te muta\u021biile genei KRAS FOTO Pharmacy Magazine<\/div>\n<\/div>\n<p>Cercet\u0103torii de la Johns Hopkins Kimmel Cancer Center \u0219i Skip Viragh Center for Pancreatic Cancer au publicat primele rezultate ale unei strategii preventive care vizeaz\u0103 muta\u021biile genei KRAS, una dintre cele mai frecvente cauze genetice ale adenocarcinomului ductal pancreatic. Echipa a dezvoltat un vaccin experimental pe baz\u0103 de peptide, denumit mKRAS-VAX, conceput pentru a antrena sistemul imunitar s\u0103 recunoasc\u0103 \u0219i s\u0103 elimine celulele care prezint\u0103 muta\u021bii frecvente ale genei KRAS \u00eenainte ca acestea s\u0103 evolueze spre cancer, potrivit <a href=\"https:\/\/bioengineer.org\/experimental-kras-vaccine-stimulates-immune-response-in-high-risk-pancreatic-cancer-patients\/\" rel=\"nofollow\">Bioengineer.<\/a><\/p>\n<p>Cancerul pancreatic se dezvolt\u0103, de regul\u0103, lent, pe parcursul mai multor ani, pornind de la leziuni precanceroase, cum sunt chisturile pancreatice. \u00centruc\u00e2t muta\u021biile KRAS sunt prezente \u00een majoritatea cazurilor de cancer pancreatic \u0219i \u00een multe dintre leziunile precanceroase, cercet\u0103torii au ales s\u0103 le \u021binteasc\u0103, cu scopul de a opri evolu\u021bia bolii \u00eentr-un stadiu cu risc crescut.<\/p>\n<p>Studiul a urm\u0103rit \u00een principal evaluarea siguran\u021bei \u0219i a capacit\u0103\u021bii vaccinului de a stimula un r\u0103spuns imunitar, \u00een cadrul unui studiu clinic de faz\u0103 I, primul efectuat la oameni. Dou\u0103zeci de participan\u021bi cu predispozi\u021bie ereditar\u0103 la <a href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/patru-semne-ale-cancerului-pancreatic-la-care-2400642.html\">cancer pancreatic<\/a> \u0219i cu anomalii pancreatice depistate prin investiga\u021bii imagistice au primit c\u00e2te patru doze de vaccin, administrate pe parcursul a 13 s\u0103pt\u0103m\u00e2ni, \u00eentre aprilie 2022 \u0219i februarie 2026. Cercet\u0103torii au monitorizat reac\u021biile adverse \u0219i r\u0103spunsul imun specific \u00eempotriva KRAS prin analize de s\u00e2nge \u0219i evalu\u0103ri periodice.<\/p>\n<h2>Vaccinul a stimulat r\u0103spunsul imunitar la 90% dintre participan\u021bi<\/h2>\n<p>Monitorizarea r\u0103spunsului imun a ar\u0103tat c\u0103 18 dintre cei 20 de participan\u021bi (90%) au dezvoltat un r\u0103spuns semnificativ \u00eendreptat \u00eempotriva formelor mutante ale proteinei KRAS. \u00cen medie, activitatea limfocitelor T specifice acestor muta\u021bii a crescut de 18,2 ori, ceea ce indic\u0103 faptul c\u0103 vaccinul a activat cu succes celulele imunitare capabile s\u0103 recunoasc\u0103 antigenele asociate muta\u021biilor KRAS.<\/p>\n<p>Analize imunologice suplimentare au eviden\u021biat at\u00e2t r\u0103spunsuri ale limfocitelor T CD4+, c\u00e2t \u0219i ale celor CD8+, precum \u0219i formarea unor limfocite T cu memorie, care s-au men\u021binut \u00een timp. Mai mult, clonele de limfocite T specifice KRAS au r\u0103mas detectabile p\u00e2n\u0103 la doi ani dup\u0103 vaccinare, ceea ce sugereaz\u0103 c\u0103 r\u0103spunsul imun ar putea oferi o supraveghere de lung\u0103 durat\u0103 \u00eempotriva apari\u021biei bolii.<\/p>\n<p>Dup\u0103 o perioad\u0103 median\u0103 de urm\u0103rire de 16,5 luni, niciunul dintre participan\u021bi nu a dezvoltat <a href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/ce-este-cancerul-de-pancreas-si-de-ce-e-atat-de-2501095.html\">cancer pancreatic<\/a> \u0219i nici leziuni cu risc ridicat care s\u0103 necesite interven\u021bie chirurgical\u0103. Reac\u021biile adverse asociate tratamentului au fost u\u0219oare p\u00e2n\u0103 la moderate, cele mai frecvente fiind reac\u021biile la locul inject\u0103rii \u0219i simptome asem\u0103n\u0103toare gripei, precum oboseala \u0219i frisoanele.<\/p>\n<p>\u00centruc\u00e2t studiul nu a fost conceput pentru a demonstra c\u0103 vaccinul previne apari\u021bia cancerului, autorii subliniaz\u0103 limitele cercet\u0103rii: num\u0103rul participan\u021bilor este redus, iar perioada de monitorizare este \u00eenc\u0103 prea scurt\u0103 pentru a permite concluzii clinice definitive. Cu toate acestea, ei consider\u0103 c\u0103 rezultatele reprezint\u0103 o dovad\u0103 de principiu c\u0103 vaccinarea \u021bintit\u0103 \u00eempotriva muta\u021biilor KRAS poate genera un r\u0103spuns imun de durat\u0103 la persoanele cu risc ereditar crescut de cancer pancreatic.<\/p>\n<h2>Ce au observat cercet\u0103torii \u00een cazul chisturilor pancreatice<\/h2>\n<p>Cercet\u0103torii au realizat \u0219i analize exploratorii privind evolu\u021bia chisturilor pancreatice la participan\u021bii care au efectuat investiga\u021bii imagistice de control. La cinci dintre cei cu chisturi de mici dimensiuni s-a observat dispari\u021bia complet\u0103 a acestora pe imagini, \u00een timp ce la al\u021bi trei s-a \u00eenregistrat o regresie par\u021bial\u0103. \u00cen celelalte cazuri, chisturile au r\u0103mas stabile.<\/p>\n<p>Echipa de cercetare raportase anterior c\u0103 un vaccin \u00eempotriva muta\u021biilor KRAS, testat la pacien\u021bi opera\u021bi \u0219i cu risc ridicat de recidiv\u0103, a fost asociat cu rezultate promi\u021b\u0103toare pe termen lung, \u00een special \u00een r\u00e2ndul celor care au dezvoltat un r\u0103spuns imun puternic. Aceste rezultate au stat la baza lans\u0103rii studiului axat pe preven\u021bie, iar noile date sus\u021bin continuarea evalu\u0103rii acestei abord\u0103ri \u00een studii mai ample.<\/p>\n<p><\/main><\/p>\n<footer class=\"svelte-x63bga\">\n<div class=\"related-wrap related-footer svelte-78g0vl\"><span class=\"related-label svelte-78g0vl\">Cite\u0219te \u0219i<\/span><a class=\"related svelte-78g0vl\" data-gtrack=\"{&quot;event&quot;:&quot;utm_click&quot;,&quot;data&quot;:{&quot;event_category&quot;:&quot;article_related&quot;}}\" href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/cancerul-pancreatic-detectat-mai-devreme-cu-2527211.html\" title=\"Alt articol de interes pentru tine\"><img decoding=\"async\" class=\"thumb svelte-78g0vl\" src=\"https:\/\/cdn.adh.reperio.news\/image-9\/96a75b7a-b25e-449a-bb6e-ae7badb93670\/index.jpeg\" alt loading=\"lazy\" width=\"80\" height=\"54\"><span class=\"title svelte-78g0vl\">Cancerul pancreatic, detectat mai devreme cu ajutorul inteligen\u021bei artificiale   <\/span><\/a><a class=\"related svelte-78g0vl\" data-gtrack=\"{&quot;event&quot;:&quot;utm_click&quot;,&quot;data&quot;:{&quot;event_category&quot;:&quot;article_related&quot;}}\" href=\"https:\/\/adevarul.ro\/stiri-interne\/sanatate\/premiera-in-romania-o-interventie-robotica-pentru-2542164.html\" title=\"Alt articol de interes pentru tine\"><img decoding=\"async\" class=\"thumb svelte-78g0vl\" src=\"https:\/\/cdn.adh.reperio.news\/image-1\/17ab1409-9dbe-400a-85ee-31cb1492521c\/index.jpeg\" alt loading=\"lazy\" width=\"80\" height=\"54\"><span class=\"title svelte-78g0vl\">Premier\u0103 \u00een Rom\u00e2nia: o interven\u021bie robotic\u0103 pentru cancerul de prostat\u0103 realizat\u0103 la B\u0103neasa Tumor Center Hospital introduce o tehnic\u0103 avansat\u0103 de verificare a siguran\u021bei oncologice \u00een timpul opera\u021biei <\/span><\/a><a class=\"related svelte-78g0vl\" data-gtrack=\"{&quot;event&quot;:&quot;utm_click&quot;,&quot;data&quot;:{&quot;event_category&quot;:&quot;article_related&quot;}}\" href=\"https:\/\/adevarul.ro\/dezvoltare-personala\/sport-si-nutritie\/somnul-si-sportul-pot-limita-efectele-unor-mutatii-2542697.html\" title=\"Alt articol de interes pentru tine\"><img decoding=\"async\" class=\"thumb svelte-78g0vl\" src=\"https:\/\/cdn.adh.reperio.news\/image-8\/8a51bd36-9e37-47b1-b62c-cb3ff4405d4a\/index.jpeg\" alt loading=\"lazy\" width=\"80\" height=\"54\"><span class=\"title svelte-78g0vl\">Somnul \u0219i sportul pot limita efectele unor muta\u021bii care cresc riscul de infarct \u0219i AVC. Descoperirea publicat\u0103 \u00een Nature<\/span><\/a><\/div>\n<div class=\"meta svelte-x63bga\">\n<div class=\"authors svelte-x63bga\"><span class=\"names svelte-x63bga\"><a href=\"https:\/\/adevarul.ro\/author\/46\" rel=\"author\" class=\"svelte-x63bga\">Teodora Marinescu<\/a><\/span><\/div>\n<\/div>\n<p><a class=\"moreFromCategory svelte-x63bga\" href=\"https:\/\/adevarul.ro\/stil-de-viata\/stiinta\" title=\"\u0218tiin\u021b\u0103\">Mai multe din <strong class=\"svelte-x63bga\">\u0218tiin\u021b\u0103<\/strong> \u203a<\/a><\/footer>\n<\/article>\n<p>[analyse_source url=&#8221;https:\/\/adevarul.ro\/stil-de-viata\/stiinta\/un-vaccin-experimental-pentru-prevenirea-2543925.html&#8221;]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[analyse_image type=&#8221;featured&#8221; src=&#8221;https:\/\/cdn.adh.reperio.news\/image-f\/fa6f780b-0f0f-4a6d-aa50-fc0d97010c1d\/index.jpeg?p=f%3Djpeg%26w%3D1200%26h%3D630%26r%3Dcover&#8221;] Home Stil de via\u021b\u0103 \u0218tiin\u021b\u0103 Un vaccin experimental pentru prevenirea cancerului pancreatic a declan\u0219at un r\u0103spuns imunitar la 90% dintre subiec\u021bi Un vaccin experimental care \u021binte\u0219te muta\u021biile genei KRAS a declan\u0219at un r\u0103spuns imunitar puternic la 90% dintre participan\u021bii cu risc ridicat de cancer pancreatic. Vaccinul experimental \u021binte\u0219te muta\u021biile genei KRAS FOTO [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[89],"tags":[19,226],"class_list":["post-2048809","post","type-post","status-publish","format-standard","hentry","category-romania","tag-adevarul","tag-crawlmanager"],"_links":{"self":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/2048809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2048809"}],"version-history":[{"count":0,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/2048809\/revisions"}],"wp:attachment":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2048809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2048809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2048809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}