{"id":1721423,"date":"2026-01-30T12:42:29","date_gmt":"2026-01-30T09:42:29","guid":{"rendered":"https:\/\/analyse.optim.biz\/?p=1721423"},"modified":"2026-01-30T12:42:29","modified_gmt":"2026-01-30T09:42:29","slug":"read-this-if-youre-considering-spironolactone-for-acne","status":"publish","type":"post","link":"https:\/\/analyse.optim.biz\/?p=1721423","title":{"rendered":"Read This If You&#8217;re Considering Spironolactone For Acne"},"content":{"rendered":"<p><main id=\"main_1-0\" class=\"comp main layout-body--continuous-scroll mntl-block\" data-tracking-container=\"true\"><\/p>\n<article id=\"beauty-article--sc_1-0\" class=\"comp beauty-article--sc beauty-article mntl-article mntl-article--three-column sc-ad-container\" data-tracking-container=\"true\">\n<div class=\"loc article-header\">\n<div id=\"article-header_1-0\" class=\"comp article-header mntl-block article-top\">\n<h1 id=\"article-heading_1-0\" class=\"comp article-heading mntl-text-block\">Read This If You&#8217;re Considering Spironolactone For Acne<\/h1>\n<p id=\"article-subheading_1-0\" class=\"comp article-subheading mntl-text-block\">Here&#8217;s what dermatologists have to say. <\/p>\n<div id=\"article-meta_1-0\" class=\"comp article-meta mntl-article-meta mntl-block\" data-tracking-container=\"true\">\n<div id=\"bylines_1-0\" class=\"comp bylines beauty-bylines mntl-bylines\" data-tracking-container=\"true\">\n<div id=\"mntl-bylines__group_1-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--author\">\n<div id=\"mntl-bylines__item_1-0\" class=\"comp mntl-bylines__item mntl-attribution__item mntl-attribution__item--has-date\"><span class=\"mntl-attribution__item-descriptor\">By<\/span><\/p>\n<div data-tooltip=\"Becci is a contributing beauty editor at Cosmopolitan. She also contributes regularly to Byrdie, Stylist, Fabulous, and Brides.\" data-inline-tooltip=\"true\"> Becci Vallis<\/p>\n<div id=\"mntl-author-tooltip_1-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top \">\n<div class=\"mntl-author-tooltip__image-wrapper\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" alt=\"Byrdie contributing writer Becci Vallis headshot\" class=\"lazyload mntl-author-tooltip__image mntl-image universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7.webp\" title=\"cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7.webp\" width=\"200\" height=\"200\" class=\"img--noscript mntl-author-tooltip__image mntl-image universal-image__image\" alt=\"Byrdie contributing writer Becci Vallis headshot\" title=\"cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7\"><\/div>\n<\/div>\n<div id=\"mntl-author-tooltip__name_1-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \">\nBecci Vallis\n<\/div>\n<div id=\"mntl-author-tooltip__social-nav_1-0\" class=\"comp mntl-author-tooltip__social-nav beauty-social-nav mntl-social-nav social-nav--tooltip\" data-tracking-container=\"true\">\n<ul class=\"social-nav__list\">\n<li class=\"social-nav__item social-nav__item--instagram\"><\/ul>\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\nBecci is a contributing beauty editor at Cosmopolitan. She also contributes regularly to Byrdie, Stylist, Fabulous, and Brides.\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nByrdie&#8217;s Editorial Guidelines\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mntl-attribution__item-date\">Published on January 30, 2026 07:42AM<\/div>\n<\/div>\n<div id=\"mntl-bylines__group_2-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--beauty_wellness_reviewer\">\n<div id=\"mntl-bylines__item_2-0\" class=\"comp mntl-bylines__item mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Reviewed by<\/span><\/p>\n<div data-tooltip=\"&lt;p&gt;Karen Kagha, MD, FAAD, is a Boston-based board-certified dermatologist. She is currently a Cosmetic and Laser Fellow at Harvard Massachusetts General Hospital.\u00a0&lt;\/p&gt;\" data-inline-tooltip=\"true\"> Karen Kagha, MD<\/p>\n<div id=\"mntl-author-tooltip_2-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top \">\n<div class=\"mntl-author-tooltip__image-wrapper\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" alt=\"Karen Kagha\" class=\"lazyload mntl-author-tooltip__image mntl-image universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/4-karenk-4758d39e48b34a40883c516e51821775.webp\" title=\"4-karenk-4758d39e48b34a40883c516e51821775\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/4-karenk-4758d39e48b34a40883c516e51821775.webp\" width=\"200\" height=\"200\" class=\"img--noscript mntl-author-tooltip__image mntl-image universal-image__image\" alt=\"Karen Kagha\" title=\"4-karenk-4758d39e48b34a40883c516e51821775\"><\/div>\n<\/div>\n<div id=\"mntl-author-tooltip__name_2-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Reviewed by<\/span><br \/>\nKaren Kagha, MD\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\n<p>Karen Kagha, MD, FAAD, is a Boston-based board-certified dermatologist. She is currently a Cosmetic and Laser Fellow at Harvard Massachusetts General Hospital.\u00a0<\/p>\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nAbout Byrdie&#8217;s Beauty &amp; Wellness Board\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mntl-attribution__item-postscript\">BOARD-CERTIFIED DERMATOLOGIST<\/div>\n<\/div>\n<\/div>\n<div id=\"mntl-bylines__group_3-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--fact_checker\">\n<div id=\"mntl-bylines__item_3-0\" class=\"comp mntl-bylines__item mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Fact checked by<\/span><\/p>\n<div data-tooltip=\"Anna Harris is an experienced fact-checker and researcher and a beauty writer and editor.\u00a0\" data-inline-tooltip=\"true\"> Anna Harris<\/p>\n<div id=\"mntl-author-tooltip_3-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top mntl-author-tooltip__top--no-image\">\n<div id=\"mntl-author-tooltip__name_3-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Fact checked by<\/span><br \/>\nAnna Harris\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\nAnna Harris is an experienced fact-checker and researcher and a beauty writer and editor.\u00a0\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nLEARN ABOUT BYRDIE&#8217;S EDITORIAL GUIDELINES\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-left-rail\">\n<div id=\"beauty-sticky-toc_1-0\" class=\"comp beauty-sticky-toc mntl-block js-sticky-container sticky-toc__wrapper\">\n<div id=\"sticky-toc_1-0\" class=\"comp sticky-toc mntl-universal-sticky-toc mntl-sticky-toc mntl-block sticky-toc-widget\" data-desktop-bp=\"70em\">\n<div id=\"toc-wrapper_1-0\" class=\"comp toc-wrapper mntl-toc mntl-block\" data-chop-mobile=\"true\" data-offset=\"60\" data-tracking-container=\"true\">\n<div id=\"mntl-toc__inner_1-0\" class=\"comp mntl-toc__inner mntl-block\">\n<div id=\"mntl-toc__heading_1-0\" class=\"comp mntl-toc__heading mntl-block js-toc-toggle\"><span id=\"mntl-toc__heading-text_1-0\" class=\"comp mntl-toc__heading-text mntl-text-block\">In This Article<\/span><\/p>\n<div id=\"mntl-toc-toggle_1-0\" class=\"comp mntl-toc-toggle mntl-block\">\n<div id=\"mntl-toc-toggle__btn_1-0\" class=\"comp mntl-toc-toggle__btn mntl-text-block js-mntl-toc-toggle text-label-300\" data-click-tracked=\"true\" data-collapsed-text=\"View All\" data-expanded-text=\"View Less\">View All<\/div>\n<\/div>\n<\/div>\n<div id=\"mntl-toc__mobile-toggle_1-0\" class=\"comp mntl-toc__mobile-toggle mntl-block js-sticky-toggle\"><span id=\"mntl-toc__heading-text_2-0\" class=\"comp mntl-toc__heading-text mntl-text-block\">In This Article<\/span><\/div>\n<ul id=\"mntl-toc__list_1-0\" class=\"comp mntl-toc__list mntl-toc__list-heading expert-content text-utility-300\">\n<li id=\"mntl-toc__list-item_1-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_1-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">What Is Spironolactone?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_2-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_2-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">How Does Spironolactone Work?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_3-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_3-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">What Do Studies Say About Spironolactone?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_4-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_4-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Benefits of Spironolactone<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_5-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_5-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Who Can Take Spironolactone Safely?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_6-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_6-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Spironolactone Side Effects and Safety Considerations<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_7-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_7-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Frequently Asked Questions<\/span><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-content\">\n<div id=\"article__broad-video-jw_1-0\" class=\"comp article__broad-video-jw mntl-jwplayer-broad mntl-block is-hidden\" data-pixel-depth=\"100\">\n<div id=\"mntl-jwplayer-broad__title_1-0\" class=\"comp mntl-jwplayer-broad__title mntl-block\"><button id=\"mntl-jwplayer-broad__title-icon--close_1-0\" class=\"comp mntl-jwplayer-broad__title-icon--close mntl-block text-label-100\" data-click-tracked=\"false\"><span id=\"mntl-text-block_2-0\" class=\"comp mntl-text-block\">Close<\/span><\/button><\/div>\n<\/div>\n<div id=\"mntl-block_2-0\" class=\"comp mntl-block article__body right-rail\">\n<figure id=\"mntl-universal-primary-image_1-0\" class=\"comp mntl-universal-primary-image primary-image\" data-tracking-container=\"true\">\n<div class=\"primary-image__media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" alt=\"A person with a contemplative expression resting their arm on a surface\" class=\" primary-image__image mntl-primary-image--blurry\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" class=\"loaded primary-img--noscript primary-image__image mntl-primary-image--blurry\" alt=\"A person with a contemplative expression resting their arm on a surface\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><\/div>\n<\/div><figcaption id=\"primary-image__figcap_1-0\" class=\"comp primary-image__figcap mntl-figure-caption figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>Stocksy<\/p>\n<p><\/span><\/figcaption><\/figure>\n<div id=\"mntl-sc-page_1-0\" class=\"comp mntl-sc-page mntl-block\" data-sc-sticky-offset=\"125\" data-sc-ad-label-height=\"16\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"5\" data-sc-content-positions=\"[1, 1250, 1, 1, 1, 1, 1, 1, 1]\" data-bind-scroll-on-start=\"true\">\n<div id=\"mntl-sc-block_1-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--finalverdict beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-finalverdict\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/p>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Spironolactone is an oral medication primarily used off-label to treat stubborn hormonal acne in women. <\/li>\n<li>The medication works by reducing oil production and blocking hormones that can cause acne breakouts. <\/li>\n<li>Some side effects of Spironolactone include frequent urination, menstrual cramps, and potential fatigue.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Anybody who has experience with acne knows first-hand how frustrating it can be. Whether you only dealt with it for a short period in high school or have been battling it for decades, if you&#8217;re desperate enough to get rid of the bumps on your face and\/or skin, you&#8217;re open to trying almost anything to make it go away. There&#8217;s the standard exfoliating cleansers and tretinoin, but more intense breakouts sometimes call for Accutane or even Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We&#8217;re here to talk about the latter. Spironolactone is primarily known as an oral blood pressure medication. However, dermatologists sometimes recommend their clients use it off-label to treat hormonal acne\u2014and there&#8217;s a lot of science to back up their decision. In fact, one study found that 86% of patients saw their acne improve on spironolactone therapy, and most saw results after three to six months of use. Physicians say Spironolactone works by regulating oil production, blocking acne-causing androgen receptors, and reducing the intensity and lifespan of hormonal breakouts\u2014sounds good, right?\n<\/p>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We know that taking an oral medication of any type can be scary for some, and especially if it&#8217;s used off-label. So, we spoke to two dermatologists and a cosmetic chemist and asked them everything there is to know about about using Spironolactone to treat acne. <strong>Ahead, experts share everything you need to know about spironolactone.<\/strong><\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--meetourexpert beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-meetourexpert\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_2-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Meet the Experts<\/p>\n<div id=\"mntl-sc-block-callout-body_2-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Justine Kluk, MD, is a board-certified dermatologist based in London.<\/li>\n<li>Susan Raffy is a California-based cosmetic chemist and the president of Susan Raffy Consulting.<\/li>\n<li>David Colbert, MD, is a dermatologist and the founder of the New York Dermatology Group.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Is Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is an oral form of medication that was initially developed to treat mild blood pressure irregularities and water retention. However, women with combination skin taking the drug for those aforementioned reasons soon found that one of the side effects was improved skin\u2014in particular, fewer spots and breakouts. Soon after this discovery (and plenty of clinical studies), dermatologists began prescribing Spironolactone off-label to treat difficult hormonal acne cases in women.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--ffingredients beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-ffingredients\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_3-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Spironolactone<\/p>\n<div id=\"mntl-sc-block-callout-body_3-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<p><strong>Type of ingredient:<\/strong> Oral Medication<\/p>\n<p><strong>Main benefits: <\/strong>Regulates oil production, blocks androgen receptors, and reduces the length of hormonal breakouts.<\/p>\n<p><strong>Who should use it:<\/strong> In general, women with hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant. You must have a prescription to use Spironolactone.<\/p>\n<p><strong>How often should you use it?<\/strong> Consult a dermatologist.<\/p>\n<p><strong>Works well with: <\/strong>Generally, it works well with all topical treatments.<\/p>\n<p><strong>Don&#8217;t use with:<\/strong> Check with your physician for interactions with other medications.<\/p>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Board-certified dermatologist Justine Kluk clarifies what is meant by &#8220;off-label&#8221; use: \u201cIt\u2019s not actually specifically licensed for treating acne in absence of a syndrome like PCOS, but dermatologists can prescribe the drug on an off-label basis for women who have a hormonal pattern to their spots and whose acne hasn\u2019t responded to first-line therapies such as prescription creams, antibiotics, and even Accutane.&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> How Does Spironolactone Work? <\/span><\/h2>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The impact Spironolactone has on hormones is what give it those acne-clearing superpowers. It works by blocking the effect that androgens (hormones like testosterone) have on the body. Increased androgens can increase sebum production, which leads to clogged pores and acne flare-ups. So essentially, Spironolactone gets to the root of the cause by blocking the hormones at the core of the problem, which means the acne glands and hair follicles won\u2019t get overloaded, thus reducing the likelihood of developing pimples.\n<\/p>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> And like most skincare products, topical or oral, you have to give Spironolactone some time to work. Kluk says it takes around three months to see results.\n<\/p>\n<h2 id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Do Studies Say About Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> In one study, 85% of patients saw an improvement in their acne, and 55% were completely clear of acne after taking Spironolactone. Another study offered similar results, demonstrating that acne of all severity responded to Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The good thing is that there\u2019s no time limit to how long you can take the drug, unlike the antibiotics that are often prescribed for acne. But Kluk says that many patients see improvement after just two &#8220;rounds&#8221; of treatment and find that they don&#8217;t have to continue taking the medication.\n<\/p>\n<figure id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block beauty-sc-block-image mntl-sc-block-image figure-landscape figure-high-res\">\n<div class=\"figure-media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"799\" alt=\"woman's spironolactone before and after photo\" class=\"lazyload mntl-image mntl-image universal-image__image\" id=\"mntl-sc-block-image_1-0\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" width=\"1000\" height=\"799\" class=\"img--noscript mntl-image mntl-image universal-image__image\" alt=\"woman's spironolactone before and after photo\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><\/div>\n<\/div><figcaption id=\"mntl-figure-caption_1-0\" class=\"comp mntl-figure-caption text-utility-100 figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>@maguaaa67 \/ Instagram<\/p>\n<p><\/span><\/figcaption><\/figure>\n<h2 id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Benefits of Spironolactone <\/span><\/h2>\n<ul id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Effective at Clearing Stubborn Hormonal Acne:<\/strong> While topical ingredients can certainly be effective for many people dealing with hormonal acne, Spironolactone can prevent blemishes from developing in the first place by blocking the androgens that stimulate sebum production. Many women dealing with stubborn hormonal acne that&#8217;s resistant to topical treatments find success in using Spironolactone.<\/li>\n<li><strong>Can Treat Hair Loss in Women:<\/strong> Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss. It hasn&#8217;t been found to have the same impact on men, however.<\/li>\n<li><strong>All-in-One Treatment: <\/strong>Because of the efficacy of Spironolactone, you may no longer need to use drying topicals to treat acne.<\/li>\n<\/ul>\n<h2 id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Who Can Take Spironolactone Safely? <\/span><\/h2>\n<p id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is a prescription medication that should only be used under the direct supervision of a physician. Because the drug tampers with hormone levels and testosterone, it\u2019s recommended for use by women only. It also can\u2019t be prescribed for those who are trying to get pregnant, so bear this in mind if you\u2019re planning to conceive any time soon. Dr. Colbert also notes that in some cases, Spironolactone &#8220;may alter blood potassium levels, therefore, people with kidney disease should not take it,&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Spironolactone Side Effects and Safety Considerations <\/span><\/h2>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">The negative side effects associated with taking oral doses of Spironolactone include &#8220;electrolyte imbalance, breast tenderness, irregular periods, and increased urination,&#8221; says Raffy.\u00a0We elaborate, below.\n<\/p>\n<ol id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Frequent Urination: <\/strong>Spironolactone is a diuretic, so it removes excess fluid from the body via urination. Colbert recommends that patients stay well-hydrated and carry a water bottle while taking Spironolactone to minimize dehydration from the diuretic effect.<\/li>\n<li><strong>Increased Menstruation Cramps: <\/strong>Spironolactone can alter the body&#8217;s electrolyte balance (think potassium, magnesium, and calcium)\u2014thereby leading to low sodium. An imbalance of electrolytes can lead to muscle cramps, which can be particularly problematic during menstruation, when cramps are already an issue. If experiencing any form of cramps or dizziness, speak to a doctor.<\/li>\n<li><strong>Hormonal Acne: <\/strong>While the medication helps with breakouts, it also alters the hormonal balance. As many know from experiencing hormonal breakouts, acne can result.<\/li>\n<li><strong>Fatigue: <\/strong>Spironolactone blocks certain hormones and lowers blood pressure\u2014both of which can cause fatigue. If you feel suddenly tired (and that&#8217;s unusual) it&#8217;s best to seek the advice of an expert before continuing the medication.<\/li>\n<\/ol>\n<div id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block beauty-sc-block-faq--expanded beauty-sc-block-faq mntl-sc-block-faq mntl-block is-expanded\">\n<div id=\"mntl-sc-block-faq__title_1-0\" class=\"comp mntl-sc-block-faq__title mntl-text-block\">FAQ<\/div>\n<ul id=\"mntl-sc-block-faq__content_1-0\" class=\"comp mntl-sc-block-faq__content mntl-accordion \" data-tracking-container=\"true\">\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"1\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_1-0-section-0\"><span class=\"accordion__title\">Who can and can&#8217;t use Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_1-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>In general, dermatologists tend to recommend Spironolactone to women with persistent hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"2\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_2-0-section-1\"><span class=\"accordion__title\">Can Spironolactone cause weight gain?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_2-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>While some individuals have reported experiencing weight gain while taking Spironolactone, there is little evidence to support this. Weight gain is not considered a formal side effect of Spironolactone and it is not listed as a side effect on the packaging of the medication.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"3\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_3-0-section-2\"><span class=\"accordion__title\">Are there alternatives to Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_3-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>If you&#8217;re dealing with hormonal acne, talk to your dermatologist. They may recommend a specific birth control or prescription topical before resorting to Spironolactone.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"4\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_4-0-section-3\"><span class=\"accordion__title\">How quickly does Spironolactone work for acne?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_4-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>The American Academy of Dermatology notes that, on average, women notice improvement in their acne after taking Spironolactone for two to three months.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"5\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_5-0-section-4\"><span class=\"accordion__title\">Why is my face getting worse on Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_5-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>Since Spironolactone blocks certain hormones, the medication can cause acne to get worse at times. If it doesn&#8217;t improve with time, it&#8217;s best to seek expert input.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"citation-sources_1-0\" class=\"comp citation-sources mntl-article-sources mntl-expandable-block u-article-styles\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">Article Sources<\/span><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"citation-sources__text_1-0\" class=\"comp citation-sources__text mntl-text-block\">Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-6\">\n<p>Dermatology. &#8220;Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study.&#8221; October 2017.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience.\u00a0<em>J Clin Aesthet Dermatol<\/em>. 2012;5(3):37-50.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients.\u00a0<em>Int J Womens Dermatol<\/em>. 2017;3(2):111-115. doi:10.1016\/j.ijwd.2016.12.002<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-5\">\n<p>BMJ Open. &#8220;Spironolactone for adult female acne.&#8221; 2021.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-4\">\n<p>Rathnayake D, Sinclair R. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.\u00a0<em>Dermatol Clin<\/em>. 2010;28(3):611-618. doi:10.1016\/j.det.2010.03.011<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-post-content\">\n<div id=\"beauty-breadcrumbs--chips_1-0\" class=\"comp beauty-breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read more:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block text-label-300 breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Skin<\/span><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Skin Concerns<\/span><\/li>\n<li id=\"mntl-breadcrumbs__item_3-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Acne<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/article>\n<div id=\"recirc_1-0\" class=\"comp recirc mntl-block\" data-tracking-container=\"true\">\n<h2 id=\"recirc__heading_1-0\" class=\"comp recirc__heading mntl-text-block\">Related Stories<\/h2>\n<ul id=\"card-list-1_1-0\" class=\"comp card-list-1 card-list mntl-block l-container\" data-tracking-container=\"true\">\n<li id=\"card-list__item_1-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Person receiving a skin treatment with a handheld device operated by a technician wearing gloves\" class=\"lazyload card__img universal-image__image\" 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mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"A person applying moisturizer to their face in a beforeandafter skincare comparison\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-oil-free-moisturizers-tout-recirc-ad0b8ea357c8440da7e6af8aa5d05350-15.webp\" title=\"byr-oil-free-moisturizers-tout-recirc-ad0b8ea357c8440da7e6af8aa5d05350-15\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-oil-free-moisturizers-tout-recirc-ad0b8ea357c8440da7e6af8aa5d05350-15.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"A person applying moisturizer to their face in a beforeandafter skincare comparison\" title=\"byr-oil-free-moisturizers-tout-recirc-ad0b8ea357c8440da7e6af8aa5d05350-15\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">The 5 Best Oil-Free Moisturizers for Hydrated, Nongreasy Skin<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_8-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"A woman wearing oversized sunglasses a patterned scarf tied around her head and a checkered coat posing against a red background\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/anti-aging-skincare-2-edd2ab11f64e4ceba0d4db767c3f0639-21.webp\" title=\"anti-aging-skincare-2-edd2ab11f64e4ceba0d4db767c3f0639-21\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/anti-aging-skincare-2-edd2ab11f64e4ceba0d4db767c3f0639-21.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"A woman wearing oversized sunglasses a patterned scarf tied around her head and a checkered coat posing against a red background\" title=\"anti-aging-skincare-2-edd2ab11f64e4ceba0d4db767c3f0639-21\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">This Is the Anti-Aging Skincare Routine Recommended By Both Dermatologists and Aestheticians <\/span><\/span><\/div>\n<\/li>\n<\/ul>\n<ul id=\"card-list-2_1-0\" class=\"comp card-list-2 card-list mntl-block l-container\" data-tracking-container=\"true\">\n<li id=\"card-list__item_9-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Two individuals applying facial moisturizer to their cheeks\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byrdie-moisturizers-tout-baa58b5d3e3848c3a99350a16b6c0242-17.webp\" title=\"byrdie-moisturizers-tout-baa58b5d3e3848c3a99350a16b6c0242-17\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byrdie-moisturizers-tout-baa58b5d3e3848c3a99350a16b6c0242-17.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Two individuals applying facial moisturizer to their cheeks\" title=\"byrdie-moisturizers-tout-baa58b5d3e3848c3a99350a16b6c0242-17\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">The 13 Best Noncomedogenic Moisturizers for Clear, Healthy Skin<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_10-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"A person smiling closely featuring a visible lip piercing\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/smile-lines-1-3960bfe1b5c148daa807e1952a7a4ed8-17.webp\" title=\"smile-lines-1-3960bfe1b5c148daa807e1952a7a4ed8-17\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/smile-lines-1-3960bfe1b5c148daa807e1952a7a4ed8-17.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"A person smiling closely featuring a visible lip piercing\" title=\"smile-lines-1-3960bfe1b5c148daa807e1952a7a4ed8-17\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">Can You Really Soften Smile Lines? Experts Break It Down<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_11-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Person washing their face on the left and holding a bottle of La RochePosay foaming cleanser on the right\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-best-drugstore-face-washes-tout-recirc-f01e2067d52144b98dfc8e4034033971-20.webp\" title=\"byr-best-drugstore-face-washes-tout-recirc-f01e2067d52144b98dfc8e4034033971-20\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-best-drugstore-face-washes-tout-recirc-f01e2067d52144b98dfc8e4034033971-20.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Person washing their face on the left and holding a bottle of La RochePosay foaming cleanser on the right\" title=\"byr-best-drugstore-face-washes-tout-recirc-f01e2067d52144b98dfc8e4034033971-20\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">The 12 Best Drugstore Face Washes That Rival High-End Cleansers (We Put Them to the Test)<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_12-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Woman applying skincare product to her face with eyes closed focusing on her cheeks and chin\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/hormonal-acne-2-d90fce4981c448a79b864d1cf22c0bf8-10.webp\" title=\"hormonal-acne-2-d90fce4981c448a79b864d1cf22c0bf8-10\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/hormonal-acne-2-d90fce4981c448a79b864d1cf22c0bf8-10.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Woman applying skincare product to her face with eyes closed focusing on her cheeks and chin\" title=\"hormonal-acne-2-d90fce4981c448a79b864d1cf22c0bf8-10\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">These Are the Hormonal Acne Treatments Dermatologists Swear By<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_13-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Two individuals using derma rollers one on the left holding the device and the one on the right wearing a headband\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/the-best-derma-rollers-tout-recirc-d76dd17931814c0db3fcf998cdf26430-11.webp\" title=\"the-best-derma-rollers-tout-recirc-d76dd17931814c0db3fcf998cdf26430-11\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/the-best-derma-rollers-tout-recirc-d76dd17931814c0db3fcf998cdf26430-11.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Two individuals using derma rollers one on the left holding the device and the one on the right wearing a headband\" title=\"the-best-derma-rollers-tout-recirc-d76dd17931814c0db3fcf998cdf26430-11\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">The Best At-Home Derma Rollers for Radiant, Even-Toned Skin<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_14-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"A circular, elongated drop of honey on a textured white background.\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/honeydropletforface-6e639624c7f04029a5effd87eda389c2-3.webp\" title=\"honeydropletforface-6e639624c7f04029a5effd87eda389c2-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/honeydropletforface-6e639624c7f04029a5effd87eda389c2-3.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"A circular, elongated drop of honey on a textured white background.\" title=\"honeydropletforface-6e639624c7f04029a5effd87eda389c2-3\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">Honey on Your Face: Benefits and How to Use It, According to Dermatologists<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_15-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Person with visible blemishes on the cheek focused on the side profile of the face\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr_lutealacne_leadrecirc_alt3-ad44e19dbdd84a308801f3d8b9dce720-3.webp\" title=\"byr_lutealacne_leadrecirc_alt3-ad44e19dbdd84a308801f3d8b9dce720-3\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr_lutealacne_leadrecirc_alt3-ad44e19dbdd84a308801f3d8b9dce720-3.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Person with visible blemishes on the cheek focused on the side profile of the face\" title=\"byr_lutealacne_leadrecirc_alt3-ad44e19dbdd84a308801f3d8b9dce720-3\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">So, You Have the &#8220;Luteal Uglies&#8221;\u2014Here&#8217;s How to Stop the Breakout Cycle<\/span><\/span><\/div>\n<\/li>\n<li id=\"card-list__item_16-0\" class=\"comp card-list__item mntl-block \">\n<div class=\"loc card__top\">\n<div class=\"card__media mntl-image card__media universal-image__container\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"240\" alt=\"Two people applying over the counter retinol products to their faces\" class=\"lazyload card__img universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-best-over-the-counter-retinols-tout-recirc-1-231b2adb3b8644c2b4d15f8aae6fb17e-11.webp\" title=\"byr-best-over-the-counter-retinols-tout-recirc-1-231b2adb3b8644c2b4d15f8aae6fb17e-11\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/byr-best-over-the-counter-retinols-tout-recirc-1-231b2adb3b8644c2b4d15f8aae6fb17e-11.webp\" width=\"300\" height=\"240\" class=\"img--noscript card__img universal-image__image\" alt=\"Two people applying over the counter retinol products to their faces\" title=\"byr-best-over-the-counter-retinols-tout-recirc-1-231b2adb3b8644c2b4d15f8aae6fb17e-11\"><\/div>\n<\/div>\n<\/div>\n<div class=\"card__content \"><span class=\"card__title\"><span class=\"card__title-text \">The 8 Best Over-the-Counter (OTC) Retinols for Smooth, Even Skin, According to Testers<\/span><\/span><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<p><\/main><\/p>\n<article id=\"beauty-article--sc_1-0\" class=\"comp beauty-article--sc beauty-article mntl-article mntl-article--three-column sc-ad-container\" data-tracking-container=\"true\">\n<div class=\"loc article-header\">\n<div id=\"article-header_1-0\" class=\"comp article-header mntl-block article-top\">\n<h1 id=\"article-heading_1-0\" class=\"comp article-heading mntl-text-block\">Read This If You&#8217;re Considering Spironolactone For Acne<\/h1>\n<p id=\"article-subheading_1-0\" class=\"comp article-subheading mntl-text-block\">Here&#8217;s what dermatologists have to say. <\/p>\n<div id=\"article-meta_1-0\" class=\"comp article-meta mntl-article-meta mntl-block\" data-tracking-container=\"true\">\n<div id=\"bylines_1-0\" class=\"comp bylines beauty-bylines mntl-bylines\" data-tracking-container=\"true\">\n<div id=\"mntl-bylines__group_1-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--author\">\n<div id=\"mntl-bylines__item_1-0\" class=\"comp mntl-bylines__item mntl-attribution__item mntl-attribution__item--has-date\"><span class=\"mntl-attribution__item-descriptor\">By<\/span><\/p>\n<div data-tooltip=\"Becci is a contributing beauty editor at Cosmopolitan. She also contributes regularly to Byrdie, Stylist, Fabulous, and Brides.\" data-inline-tooltip=\"true\"> Becci Vallis<\/p>\n<div id=\"mntl-author-tooltip_1-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top \">\n<div class=\"mntl-author-tooltip__image-wrapper\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" alt=\"Byrdie contributing writer Becci Vallis headshot\" class=\"lazyload mntl-author-tooltip__image mntl-image universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7.webp\" title=\"cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7.webp\" width=\"200\" height=\"200\" class=\"img--noscript mntl-author-tooltip__image mntl-image universal-image__image\" alt=\"Byrdie contributing writer Becci Vallis headshot\" title=\"cdn-cliqueinc-com__cache__users__905__becci-vallis-905-1496677975-main_image-2ca837f798794a59bcddea0ee82827c7\"><\/div>\n<\/div>\n<div id=\"mntl-author-tooltip__name_1-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \">\nBecci Vallis\n<\/div>\n<div id=\"mntl-author-tooltip__social-nav_1-0\" class=\"comp mntl-author-tooltip__social-nav beauty-social-nav mntl-social-nav social-nav--tooltip\" data-tracking-container=\"true\">\n<ul class=\"social-nav__list\">\n<li class=\"social-nav__item social-nav__item--instagram\"><\/ul>\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\nBecci is a contributing beauty editor at Cosmopolitan. She also contributes regularly to Byrdie, Stylist, Fabulous, and Brides.\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nByrdie&#8217;s Editorial Guidelines\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mntl-attribution__item-date\">Published on January 30, 2026 07:42AM<\/div>\n<\/div>\n<div id=\"mntl-bylines__group_2-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--beauty_wellness_reviewer\">\n<div id=\"mntl-bylines__item_2-0\" class=\"comp mntl-bylines__item mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Reviewed by<\/span><\/p>\n<div data-tooltip=\"&lt;p&gt;Karen Kagha, MD, FAAD, is a Boston-based board-certified dermatologist. She is currently a Cosmetic and Laser Fellow at Harvard Massachusetts General Hospital.\u00a0&lt;\/p&gt;\" data-inline-tooltip=\"true\"> Karen Kagha, MD<\/p>\n<div id=\"mntl-author-tooltip_2-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top \">\n<div class=\"mntl-author-tooltip__image-wrapper\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"200\" alt=\"Karen Kagha\" class=\"lazyload mntl-author-tooltip__image mntl-image universal-image__image\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/4-karenk-4758d39e48b34a40883c516e51821775.webp\" title=\"4-karenk-4758d39e48b34a40883c516e51821775\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/4-karenk-4758d39e48b34a40883c516e51821775.webp\" width=\"200\" height=\"200\" class=\"img--noscript mntl-author-tooltip__image mntl-image universal-image__image\" alt=\"Karen Kagha\" title=\"4-karenk-4758d39e48b34a40883c516e51821775\"><\/div>\n<\/div>\n<div id=\"mntl-author-tooltip__name_2-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Reviewed by<\/span><br \/>\nKaren Kagha, MD\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\n<p>Karen Kagha, MD, FAAD, is a Boston-based board-certified dermatologist. She is currently a Cosmetic and Laser Fellow at Harvard Massachusetts General Hospital.\u00a0<\/p>\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nAbout Byrdie&#8217;s Beauty &amp; Wellness Board\n<\/div>\n<\/div>\n<\/div>\n<div class=\"mntl-attribution__item-postscript\">BOARD-CERTIFIED DERMATOLOGIST<\/div>\n<\/div>\n<\/div>\n<div id=\"mntl-bylines__group_3-0\" class=\"comp mntl-bylines__group mntl-block mntl-bylines__group--fact_checker\">\n<div id=\"mntl-bylines__item_3-0\" class=\"comp mntl-bylines__item mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Fact checked by<\/span><\/p>\n<div data-tooltip=\"Anna Harris is an experienced fact-checker and researcher and a beauty writer and editor.\u00a0\" data-inline-tooltip=\"true\"> Anna Harris<\/p>\n<div id=\"mntl-author-tooltip_3-0\" class=\"comp mntl-author-tooltip mntl-tooltip mntl-group\">\n<div class=\"mntl-author-tooltip__top mntl-author-tooltip__top--no-image\">\n<div id=\"mntl-author-tooltip__name_3-0\" class=\"comp mntl-author-tooltip__name mntl-attribution__item \"><span class=\"mntl-attribution__item-descriptor\">Fact checked by<\/span><br \/>\nAnna Harris\n<\/div>\n<div class=\"mntl-author-tooltip__bio\">\nAnna Harris is an experienced fact-checker and researcher and a beauty writer and editor.\u00a0\n<\/div>\n<\/div>\n<div class=\"mntl-author-tooltip__bottom\">\nLEARN ABOUT BYRDIE&#8217;S EDITORIAL GUIDELINES\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-left-rail\">\n<div id=\"beauty-sticky-toc_1-0\" class=\"comp beauty-sticky-toc mntl-block js-sticky-container sticky-toc__wrapper\">\n<div id=\"sticky-toc_1-0\" class=\"comp sticky-toc mntl-universal-sticky-toc mntl-sticky-toc mntl-block sticky-toc-widget\" data-desktop-bp=\"70em\">\n<div id=\"toc-wrapper_1-0\" class=\"comp toc-wrapper mntl-toc mntl-block\" data-chop-mobile=\"true\" data-offset=\"60\" data-tracking-container=\"true\">\n<div id=\"mntl-toc__inner_1-0\" class=\"comp mntl-toc__inner mntl-block\">\n<div id=\"mntl-toc__heading_1-0\" class=\"comp mntl-toc__heading mntl-block js-toc-toggle\"><span id=\"mntl-toc__heading-text_1-0\" class=\"comp mntl-toc__heading-text mntl-text-block\">In This Article<\/span><\/p>\n<div id=\"mntl-toc-toggle_1-0\" class=\"comp mntl-toc-toggle mntl-block\">\n<div id=\"mntl-toc-toggle__btn_1-0\" class=\"comp mntl-toc-toggle__btn mntl-text-block js-mntl-toc-toggle text-label-300\" data-click-tracked=\"true\" data-collapsed-text=\"View All\" data-expanded-text=\"View Less\">View All<\/div>\n<\/div>\n<\/div>\n<div id=\"mntl-toc__mobile-toggle_1-0\" class=\"comp mntl-toc__mobile-toggle mntl-block js-sticky-toggle\"><span id=\"mntl-toc__heading-text_2-0\" class=\"comp mntl-toc__heading-text mntl-text-block\">In This Article<\/span><\/div>\n<ul id=\"mntl-toc__list_1-0\" class=\"comp mntl-toc__list mntl-toc__list-heading expert-content text-utility-300\">\n<li id=\"mntl-toc__list-item_1-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_1-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">What Is Spironolactone?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_2-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_2-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">How Does Spironolactone Work?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_3-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_3-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">What Do Studies Say About Spironolactone?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_4-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_4-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Benefits of Spironolactone<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_5-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_5-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Who Can Take Spironolactone Safely?<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_6-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_6-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Spironolactone Side Effects and Safety Considerations<\/span><\/div>\n<\/li>\n<li id=\"mntl-toc__list-item_7-0\" class=\"comp mntl-toc__list-item mntl-block\">\n<div id=\"mntl-toc__list-item-heading_7-0\" class=\"comp mntl-toc__list-item-heading mntl-block\"><span class=\"link__wrapper\">Frequently Asked Questions<\/span><\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-content\">\n<div id=\"article__broad-video-jw_1-0\" class=\"comp article__broad-video-jw mntl-jwplayer-broad mntl-block is-hidden\" data-pixel-depth=\"100\">\n<div id=\"mntl-jwplayer-broad__title_1-0\" class=\"comp mntl-jwplayer-broad__title mntl-block\"><button id=\"mntl-jwplayer-broad__title-icon--close_1-0\" class=\"comp mntl-jwplayer-broad__title-icon--close mntl-block text-label-100\" data-click-tracked=\"false\"><span id=\"mntl-text-block_2-0\" class=\"comp mntl-text-block\">Close<\/span><\/button><\/div>\n<\/div>\n<div id=\"mntl-block_2-0\" class=\"comp mntl-block article__body right-rail\">\n<figure id=\"mntl-universal-primary-image_1-0\" class=\"comp mntl-universal-primary-image primary-image\" data-tracking-container=\"true\">\n<div class=\"primary-image__media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" alt=\"A person with a contemplative expression resting their arm on a surface\" class=\" primary-image__image mntl-primary-image--blurry\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" class=\"loaded primary-img--noscript primary-image__image mntl-primary-image--blurry\" alt=\"A person with a contemplative expression resting their arm on a surface\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><\/div>\n<\/div><figcaption id=\"primary-image__figcap_1-0\" class=\"comp primary-image__figcap mntl-figure-caption figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>Stocksy<\/p>\n<p><\/span><\/figcaption><\/figure>\n<div id=\"mntl-sc-page_1-0\" class=\"comp mntl-sc-page mntl-block\" data-sc-sticky-offset=\"125\" data-sc-ad-label-height=\"16\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"5\" data-sc-content-positions=\"[1, 1250, 1, 1, 1, 1, 1, 1, 1]\" data-bind-scroll-on-start=\"true\">\n<div id=\"mntl-sc-block_1-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--finalverdict beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-finalverdict\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/p>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Spironolactone is an oral medication primarily used off-label to treat stubborn hormonal acne in women. <\/li>\n<li>The medication works by reducing oil production and blocking hormones that can cause acne breakouts. <\/li>\n<li>Some side effects of Spironolactone include frequent urination, menstrual cramps, and potential fatigue.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Anybody who has experience with acne knows first-hand how frustrating it can be. Whether you only dealt with it for a short period in high school or have been battling it for decades, if you&#8217;re desperate enough to get rid of the bumps on your face and\/or skin, you&#8217;re open to trying almost anything to make it go away. There&#8217;s the standard exfoliating cleansers and tretinoin, but more intense breakouts sometimes call for Accutane or even Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We&#8217;re here to talk about the latter. Spironolactone is primarily known as an oral blood pressure medication. However, dermatologists sometimes recommend their clients use it off-label to treat hormonal acne\u2014and there&#8217;s a lot of science to back up their decision. In fact, one study found that 86% of patients saw their acne improve on spironolactone therapy, and most saw results after three to six months of use. Physicians say Spironolactone works by regulating oil production, blocking acne-causing androgen receptors, and reducing the intensity and lifespan of hormonal breakouts\u2014sounds good, right?\n<\/p>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We know that taking an oral medication of any type can be scary for some, and especially if it&#8217;s used off-label. So, we spoke to two dermatologists and a cosmetic chemist and asked them everything there is to know about about using Spironolactone to treat acne. <strong>Ahead, experts share everything you need to know about spironolactone.<\/strong><\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--meetourexpert beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-meetourexpert\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_2-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Meet the Experts<\/p>\n<div id=\"mntl-sc-block-callout-body_2-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Justine Kluk, MD, is a board-certified dermatologist based in London.<\/li>\n<li>Susan Raffy is a California-based cosmetic chemist and the president of Susan Raffy Consulting.<\/li>\n<li>David Colbert, MD, is a dermatologist and the founder of the New York Dermatology Group.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Is Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is an oral form of medication that was initially developed to treat mild blood pressure irregularities and water retention. However, women with combination skin taking the drug for those aforementioned reasons soon found that one of the side effects was improved skin\u2014in particular, fewer spots and breakouts. Soon after this discovery (and plenty of clinical studies), dermatologists began prescribing Spironolactone off-label to treat difficult hormonal acne cases in women.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--ffingredients beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-ffingredients\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_3-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Spironolactone<\/p>\n<div id=\"mntl-sc-block-callout-body_3-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<p><strong>Type of ingredient:<\/strong> Oral Medication<\/p>\n<p><strong>Main benefits: <\/strong>Regulates oil production, blocks androgen receptors, and reduces the length of hormonal breakouts.<\/p>\n<p><strong>Who should use it:<\/strong> In general, women with hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant. You must have a prescription to use Spironolactone.<\/p>\n<p><strong>How often should you use it?<\/strong> Consult a dermatologist.<\/p>\n<p><strong>Works well with: <\/strong>Generally, it works well with all topical treatments.<\/p>\n<p><strong>Don&#8217;t use with:<\/strong> Check with your physician for interactions with other medications.<\/p>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Board-certified dermatologist Justine Kluk clarifies what is meant by &#8220;off-label&#8221; use: \u201cIt\u2019s not actually specifically licensed for treating acne in absence of a syndrome like PCOS, but dermatologists can prescribe the drug on an off-label basis for women who have a hormonal pattern to their spots and whose acne hasn\u2019t responded to first-line therapies such as prescription creams, antibiotics, and even Accutane.&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> How Does Spironolactone Work? <\/span><\/h2>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The impact Spironolactone has on hormones is what give it those acne-clearing superpowers. It works by blocking the effect that androgens (hormones like testosterone) have on the body. Increased androgens can increase sebum production, which leads to clogged pores and acne flare-ups. So essentially, Spironolactone gets to the root of the cause by blocking the hormones at the core of the problem, which means the acne glands and hair follicles won\u2019t get overloaded, thus reducing the likelihood of developing pimples.\n<\/p>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> And like most skincare products, topical or oral, you have to give Spironolactone some time to work. Kluk says it takes around three months to see results.\n<\/p>\n<h2 id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Do Studies Say About Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> In one study, 85% of patients saw an improvement in their acne, and 55% were completely clear of acne after taking Spironolactone. Another study offered similar results, demonstrating that acne of all severity responded to Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The good thing is that there\u2019s no time limit to how long you can take the drug, unlike the antibiotics that are often prescribed for acne. But Kluk says that many patients see improvement after just two &#8220;rounds&#8221; of treatment and find that they don&#8217;t have to continue taking the medication.\n<\/p>\n<figure id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block beauty-sc-block-image mntl-sc-block-image figure-landscape figure-high-res\">\n<div class=\"figure-media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"799\" alt=\"woman's spironolactone before and after photo\" class=\"lazyload mntl-image mntl-image universal-image__image\" id=\"mntl-sc-block-image_1-0\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" width=\"1000\" height=\"799\" class=\"img--noscript mntl-image mntl-image universal-image__image\" alt=\"woman's spironolactone before and after photo\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><\/div>\n<\/div><figcaption id=\"mntl-figure-caption_1-0\" class=\"comp mntl-figure-caption text-utility-100 figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>@maguaaa67 \/ Instagram<\/p>\n<p><\/span><\/figcaption><\/figure>\n<h2 id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Benefits of Spironolactone <\/span><\/h2>\n<ul id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Effective at Clearing Stubborn Hormonal Acne:<\/strong> While topical ingredients can certainly be effective for many people dealing with hormonal acne, Spironolactone can prevent blemishes from developing in the first place by blocking the androgens that stimulate sebum production. Many women dealing with stubborn hormonal acne that&#8217;s resistant to topical treatments find success in using Spironolactone.<\/li>\n<li><strong>Can Treat Hair Loss in Women:<\/strong> Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss. It hasn&#8217;t been found to have the same impact on men, however.<\/li>\n<li><strong>All-in-One Treatment: <\/strong>Because of the efficacy of Spironolactone, you may no longer need to use drying topicals to treat acne.<\/li>\n<\/ul>\n<h2 id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Who Can Take Spironolactone Safely? <\/span><\/h2>\n<p id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is a prescription medication that should only be used under the direct supervision of a physician. Because the drug tampers with hormone levels and testosterone, it\u2019s recommended for use by women only. It also can\u2019t be prescribed for those who are trying to get pregnant, so bear this in mind if you\u2019re planning to conceive any time soon. Dr. Colbert also notes that in some cases, Spironolactone &#8220;may alter blood potassium levels, therefore, people with kidney disease should not take it,&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Spironolactone Side Effects and Safety Considerations <\/span><\/h2>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">The negative side effects associated with taking oral doses of Spironolactone include &#8220;electrolyte imbalance, breast tenderness, irregular periods, and increased urination,&#8221; says Raffy.\u00a0We elaborate, below.\n<\/p>\n<ol id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Frequent Urination: <\/strong>Spironolactone is a diuretic, so it removes excess fluid from the body via urination. Colbert recommends that patients stay well-hydrated and carry a water bottle while taking Spironolactone to minimize dehydration from the diuretic effect.<\/li>\n<li><strong>Increased Menstruation Cramps: <\/strong>Spironolactone can alter the body&#8217;s electrolyte balance (think potassium, magnesium, and calcium)\u2014thereby leading to low sodium. An imbalance of electrolytes can lead to muscle cramps, which can be particularly problematic during menstruation, when cramps are already an issue. If experiencing any form of cramps or dizziness, speak to a doctor.<\/li>\n<li><strong>Hormonal Acne: <\/strong>While the medication helps with breakouts, it also alters the hormonal balance. As many know from experiencing hormonal breakouts, acne can result.<\/li>\n<li><strong>Fatigue: <\/strong>Spironolactone blocks certain hormones and lowers blood pressure\u2014both of which can cause fatigue. If you feel suddenly tired (and that&#8217;s unusual) it&#8217;s best to seek the advice of an expert before continuing the medication.<\/li>\n<\/ol>\n<div id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block beauty-sc-block-faq--expanded beauty-sc-block-faq mntl-sc-block-faq mntl-block is-expanded\">\n<div id=\"mntl-sc-block-faq__title_1-0\" class=\"comp mntl-sc-block-faq__title mntl-text-block\">FAQ<\/div>\n<ul id=\"mntl-sc-block-faq__content_1-0\" class=\"comp mntl-sc-block-faq__content mntl-accordion \" data-tracking-container=\"true\">\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"1\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_1-0-section-0\"><span class=\"accordion__title\">Who can and can&#8217;t use Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_1-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>In general, dermatologists tend to recommend Spironolactone to women with persistent hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"2\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_2-0-section-1\"><span class=\"accordion__title\">Can Spironolactone cause weight gain?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_2-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>While some individuals have reported experiencing weight gain while taking Spironolactone, there is little evidence to support this. Weight gain is not considered a formal side effect of Spironolactone and it is not listed as a side effect on the packaging of the medication.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"3\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_3-0-section-2\"><span class=\"accordion__title\">Are there alternatives to Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_3-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>If you&#8217;re dealing with hormonal acne, talk to your dermatologist. They may recommend a specific birth control or prescription topical before resorting to Spironolactone.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"4\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_4-0-section-3\"><span class=\"accordion__title\">How quickly does Spironolactone work for acne?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_4-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>The American Academy of Dermatology notes that, on average, women notice improvement in their acne after taking Spironolactone for two to three months.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"5\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_5-0-section-4\"><span class=\"accordion__title\">Why is my face getting worse on Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_5-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>Since Spironolactone blocks certain hormones, the medication can cause acne to get worse at times. If it doesn&#8217;t improve with time, it&#8217;s best to seek expert input.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"citation-sources_1-0\" class=\"comp citation-sources mntl-article-sources mntl-expandable-block u-article-styles\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">Article Sources<\/span><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"citation-sources__text_1-0\" class=\"comp citation-sources__text mntl-text-block\">Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-6\">\n<p>Dermatology. &#8220;Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study.&#8221; October 2017.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience.\u00a0<em>J Clin Aesthet Dermatol<\/em>. 2012;5(3):37-50.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients.\u00a0<em>Int J Womens Dermatol<\/em>. 2017;3(2):111-115. doi:10.1016\/j.ijwd.2016.12.002<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-5\">\n<p>BMJ Open. &#8220;Spironolactone for adult female acne.&#8221; 2021.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-4\">\n<p>Rathnayake D, Sinclair R. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.\u00a0<em>Dermatol Clin<\/em>. 2010;28(3):611-618. doi:10.1016\/j.det.2010.03.011<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"loc article-post-content\">\n<div id=\"beauty-breadcrumbs--chips_1-0\" class=\"comp beauty-breadcrumbs--chips mntl-universal-breadcrumbs--chips mntl-block\">\n<div id=\"mntl-breadcrumbs__read-more_1-0\" class=\"comp mntl-breadcrumbs__read-more mntl-text-block text-title-100\">Read more:<\/div>\n<ul id=\"mntl-universal-breadcrumbs_1-0\" class=\"comp mntl-universal-breadcrumbs mntl-block text-label-300 breadcrumbs\" data-tracking-container=\"true\">\n<li id=\"mntl-breadcrumbs__item_1-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Skin<\/span><\/li>\n<li id=\"mntl-breadcrumbs__item_2-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Skin Concerns<\/span><\/li>\n<li id=\"mntl-breadcrumbs__item_3-0\" class=\"comp mntl-breadcrumbs__item mntl-block\"><span class=\"link__wrapper\">Acne<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/article>\n<div class=\"loc article-content\">\n<div id=\"article__broad-video-jw_1-0\" class=\"comp article__broad-video-jw mntl-jwplayer-broad mntl-block is-hidden\" data-pixel-depth=\"100\">\n<div id=\"mntl-jwplayer-broad__title_1-0\" class=\"comp mntl-jwplayer-broad__title mntl-block\"><button id=\"mntl-jwplayer-broad__title-icon--close_1-0\" class=\"comp mntl-jwplayer-broad__title-icon--close mntl-block text-label-100\" data-click-tracked=\"false\"><span id=\"mntl-text-block_2-0\" class=\"comp mntl-text-block\">Close<\/span><\/button><\/div>\n<\/div>\n<div id=\"mntl-block_2-0\" class=\"comp mntl-block article__body right-rail\">\n<figure id=\"mntl-universal-primary-image_1-0\" class=\"comp mntl-universal-primary-image primary-image\" data-tracking-container=\"true\">\n<div class=\"primary-image__media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" alt=\"A person with a contemplative expression resting their arm on a surface\" class=\" primary-image__image mntl-primary-image--blurry\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/acne-2-7a0b62959efc44ff91f1e8de664a7813-24.webp\" width=\"1540\" height=\"1155\" class=\"loaded primary-img--noscript primary-image__image mntl-primary-image--blurry\" alt=\"A person with a contemplative expression resting their arm on a surface\" title=\"acne-2-7a0b62959efc44ff91f1e8de664a7813-24\"><\/div>\n<\/div><figcaption id=\"primary-image__figcap_1-0\" class=\"comp primary-image__figcap mntl-figure-caption figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>Stocksy<\/p>\n<p><\/span><\/figcaption><\/figure>\n<div id=\"mntl-sc-page_1-0\" class=\"comp mntl-sc-page mntl-block\" data-sc-sticky-offset=\"125\" data-sc-ad-label-height=\"16\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"5\" data-sc-content-positions=\"[1, 1250, 1, 1, 1, 1, 1, 1, 1]\" data-bind-scroll-on-start=\"true\">\n<div id=\"mntl-sc-block_1-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--finalverdict beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-finalverdict\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/p>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Spironolactone is an oral medication primarily used off-label to treat stubborn hormonal acne in women. <\/li>\n<li>The medication works by reducing oil production and blocking hormones that can cause acne breakouts. <\/li>\n<li>Some side effects of Spironolactone include frequent urination, menstrual cramps, and potential fatigue.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Anybody who has experience with acne knows first-hand how frustrating it can be. Whether you only dealt with it for a short period in high school or have been battling it for decades, if you&#8217;re desperate enough to get rid of the bumps on your face and\/or skin, you&#8217;re open to trying almost anything to make it go away. There&#8217;s the standard exfoliating cleansers and tretinoin, but more intense breakouts sometimes call for Accutane or even Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We&#8217;re here to talk about the latter. Spironolactone is primarily known as an oral blood pressure medication. However, dermatologists sometimes recommend their clients use it off-label to treat hormonal acne\u2014and there&#8217;s a lot of science to back up their decision. In fact, one study found that 86% of patients saw their acne improve on spironolactone therapy, and most saw results after three to six months of use. Physicians say Spironolactone works by regulating oil production, blocking acne-causing androgen receptors, and reducing the intensity and lifespan of hormonal breakouts\u2014sounds good, right?\n<\/p>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We know that taking an oral medication of any type can be scary for some, and especially if it&#8217;s used off-label. So, we spoke to two dermatologists and a cosmetic chemist and asked them everything there is to know about about using Spironolactone to treat acne. <strong>Ahead, experts share everything you need to know about spironolactone.<\/strong><\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--meetourexpert beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-meetourexpert\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_2-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Meet the Experts<\/p>\n<div id=\"mntl-sc-block-callout-body_2-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Justine Kluk, MD, is a board-certified dermatologist based in London.<\/li>\n<li>Susan Raffy is a California-based cosmetic chemist and the president of Susan Raffy Consulting.<\/li>\n<li>David Colbert, MD, is a dermatologist and the founder of the New York Dermatology Group.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Is Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is an oral form of medication that was initially developed to treat mild blood pressure irregularities and water retention. However, women with combination skin taking the drug for those aforementioned reasons soon found that one of the side effects was improved skin\u2014in particular, fewer spots and breakouts. Soon after this discovery (and plenty of clinical studies), dermatologists began prescribing Spironolactone off-label to treat difficult hormonal acne cases in women.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--ffingredients beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-ffingredients\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_3-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Spironolactone<\/p>\n<div id=\"mntl-sc-block-callout-body_3-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<p><strong>Type of ingredient:<\/strong> Oral Medication<\/p>\n<p><strong>Main benefits: <\/strong>Regulates oil production, blocks androgen receptors, and reduces the length of hormonal breakouts.<\/p>\n<p><strong>Who should use it:<\/strong> In general, women with hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant. You must have a prescription to use Spironolactone.<\/p>\n<p><strong>How often should you use it?<\/strong> Consult a dermatologist.<\/p>\n<p><strong>Works well with: <\/strong>Generally, it works well with all topical treatments.<\/p>\n<p><strong>Don&#8217;t use with:<\/strong> Check with your physician for interactions with other medications.<\/p>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Board-certified dermatologist Justine Kluk clarifies what is meant by &#8220;off-label&#8221; use: \u201cIt\u2019s not actually specifically licensed for treating acne in absence of a syndrome like PCOS, but dermatologists can prescribe the drug on an off-label basis for women who have a hormonal pattern to their spots and whose acne hasn\u2019t responded to first-line therapies such as prescription creams, antibiotics, and even Accutane.&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> How Does Spironolactone Work? <\/span><\/h2>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The impact Spironolactone has on hormones is what give it those acne-clearing superpowers. It works by blocking the effect that androgens (hormones like testosterone) have on the body. Increased androgens can increase sebum production, which leads to clogged pores and acne flare-ups. So essentially, Spironolactone gets to the root of the cause by blocking the hormones at the core of the problem, which means the acne glands and hair follicles won\u2019t get overloaded, thus reducing the likelihood of developing pimples.\n<\/p>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> And like most skincare products, topical or oral, you have to give Spironolactone some time to work. Kluk says it takes around three months to see results.\n<\/p>\n<h2 id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Do Studies Say About Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> In one study, 85% of patients saw an improvement in their acne, and 55% were completely clear of acne after taking Spironolactone. Another study offered similar results, demonstrating that acne of all severity responded to Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The good thing is that there\u2019s no time limit to how long you can take the drug, unlike the antibiotics that are often prescribed for acne. But Kluk says that many patients see improvement after just two &#8220;rounds&#8221; of treatment and find that they don&#8217;t have to continue taking the medication.\n<\/p>\n<figure id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block beauty-sc-block-image mntl-sc-block-image figure-landscape figure-high-res\">\n<div class=\"figure-media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"799\" alt=\"woman's spironolactone before and after photo\" class=\"lazyload mntl-image mntl-image universal-image__image\" id=\"mntl-sc-block-image_1-0\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" width=\"1000\" height=\"799\" class=\"img--noscript mntl-image mntl-image universal-image__image\" alt=\"woman's spironolactone before and after photo\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><\/div>\n<\/div><figcaption id=\"mntl-figure-caption_1-0\" class=\"comp mntl-figure-caption text-utility-100 figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>@maguaaa67 \/ Instagram<\/p>\n<p><\/span><\/figcaption><\/figure>\n<h2 id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Benefits of Spironolactone <\/span><\/h2>\n<ul id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Effective at Clearing Stubborn Hormonal Acne:<\/strong> While topical ingredients can certainly be effective for many people dealing with hormonal acne, Spironolactone can prevent blemishes from developing in the first place by blocking the androgens that stimulate sebum production. Many women dealing with stubborn hormonal acne that&#8217;s resistant to topical treatments find success in using Spironolactone.<\/li>\n<li><strong>Can Treat Hair Loss in Women:<\/strong> Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss. It hasn&#8217;t been found to have the same impact on men, however.<\/li>\n<li><strong>All-in-One Treatment: <\/strong>Because of the efficacy of Spironolactone, you may no longer need to use drying topicals to treat acne.<\/li>\n<\/ul>\n<h2 id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Who Can Take Spironolactone Safely? <\/span><\/h2>\n<p id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is a prescription medication that should only be used under the direct supervision of a physician. Because the drug tampers with hormone levels and testosterone, it\u2019s recommended for use by women only. It also can\u2019t be prescribed for those who are trying to get pregnant, so bear this in mind if you\u2019re planning to conceive any time soon. Dr. Colbert also notes that in some cases, Spironolactone &#8220;may alter blood potassium levels, therefore, people with kidney disease should not take it,&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Spironolactone Side Effects and Safety Considerations <\/span><\/h2>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">The negative side effects associated with taking oral doses of Spironolactone include &#8220;electrolyte imbalance, breast tenderness, irregular periods, and increased urination,&#8221; says Raffy.\u00a0We elaborate, below.\n<\/p>\n<ol id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Frequent Urination: <\/strong>Spironolactone is a diuretic, so it removes excess fluid from the body via urination. Colbert recommends that patients stay well-hydrated and carry a water bottle while taking Spironolactone to minimize dehydration from the diuretic effect.<\/li>\n<li><strong>Increased Menstruation Cramps: <\/strong>Spironolactone can alter the body&#8217;s electrolyte balance (think potassium, magnesium, and calcium)\u2014thereby leading to low sodium. An imbalance of electrolytes can lead to muscle cramps, which can be particularly problematic during menstruation, when cramps are already an issue. If experiencing any form of cramps or dizziness, speak to a doctor.<\/li>\n<li><strong>Hormonal Acne: <\/strong>While the medication helps with breakouts, it also alters the hormonal balance. As many know from experiencing hormonal breakouts, acne can result.<\/li>\n<li><strong>Fatigue: <\/strong>Spironolactone blocks certain hormones and lowers blood pressure\u2014both of which can cause fatigue. If you feel suddenly tired (and that&#8217;s unusual) it&#8217;s best to seek the advice of an expert before continuing the medication.<\/li>\n<\/ol>\n<div id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block beauty-sc-block-faq--expanded beauty-sc-block-faq mntl-sc-block-faq mntl-block is-expanded\">\n<div id=\"mntl-sc-block-faq__title_1-0\" class=\"comp mntl-sc-block-faq__title mntl-text-block\">FAQ<\/div>\n<ul id=\"mntl-sc-block-faq__content_1-0\" class=\"comp mntl-sc-block-faq__content mntl-accordion \" data-tracking-container=\"true\">\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"1\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_1-0-section-0\"><span class=\"accordion__title\">Who can and can&#8217;t use Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_1-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>In general, dermatologists tend to recommend Spironolactone to women with persistent hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"2\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_2-0-section-1\"><span class=\"accordion__title\">Can Spironolactone cause weight gain?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_2-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>While some individuals have reported experiencing weight gain while taking Spironolactone, there is little evidence to support this. Weight gain is not considered a formal side effect of Spironolactone and it is not listed as a side effect on the packaging of the medication.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"3\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_3-0-section-2\"><span class=\"accordion__title\">Are there alternatives to Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_3-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>If you&#8217;re dealing with hormonal acne, talk to your dermatologist. They may recommend a specific birth control or prescription topical before resorting to Spironolactone.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"4\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_4-0-section-3\"><span class=\"accordion__title\">How quickly does Spironolactone work for acne?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_4-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>The American Academy of Dermatology notes that, on average, women notice improvement in their acne after taking Spironolactone for two to three months.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"5\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_5-0-section-4\"><span class=\"accordion__title\">Why is my face getting worse on Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_5-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>Since Spironolactone blocks certain hormones, the medication can cause acne to get worse at times. If it doesn&#8217;t improve with time, it&#8217;s best to seek expert input.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<div id=\"citation-sources_1-0\" class=\"comp citation-sources mntl-article-sources mntl-expandable-block u-article-styles\" data-scroll-offset=\"70\">\n<div class=\"loc toggle-content\">\n<div id=\"mntl-article-sources__wrapper_1-0\" class=\"comp mntl-article-sources__wrapper mntl-block\" data-click-tracked=\"true\"><span id=\"mntl-article-sources__heading_1-0\" class=\"comp mntl-article-sources__heading mntl-text-block\">Article Sources<\/span><\/div>\n<\/div>\n<div class=\"loc expandable-content\">\n<div id=\"citation-sources__text_1-0\" class=\"comp citation-sources__text mntl-text-block\">Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.<\/div>\n<div id=\"mntl-article-sources__citation-sources_1-0\" class=\"comp mntl-article-sources__citation-sources mntl-citation-sources mntl-sources\" data-tracking-container=\"true\">\n<ol class=\"mntl-sources__content\">\n<li class=\"mntl-sources__source\" id=\"citation-6\">\n<p>Dermatology. &#8220;Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study.&#8221; October 2017.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-2\">\n<p>Kim GK, Del Rosso JQ. Oral spironolactone in post-teenage female patients with acne vulgaris: practical considerations for the clinician based on current data and clinical experience.\u00a0<em>J Clin Aesthet Dermatol<\/em>. 2012;5(3):37-50.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-3\">\n<p>Charny JW, Choi JK, James WD. Spironolactone for the treatment of acne in women, a retrospective study of 110 patients.\u00a0<em>Int J Womens Dermatol<\/em>. 2017;3(2):111-115. doi:10.1016\/j.ijwd.2016.12.002<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-5\">\n<p>BMJ Open. &#8220;Spironolactone for adult female acne.&#8221; 2021.<\/p>\n<\/li>\n<li class=\"mntl-sources__source\" id=\"citation-4\">\n<p>Rathnayake D, Sinclair R. Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.\u00a0<em>Dermatol Clin<\/em>. 2010;28(3):611-618. doi:10.1016\/j.det.2010.03.011<\/p>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"mntl-sc-page_1-0\" class=\"comp mntl-sc-page mntl-block\" data-sc-sticky-offset=\"125\" data-sc-ad-label-height=\"16\" data-sc-ad-track-spacing=\"100\" data-sc-min-track-height=\"250\" data-sc-max-track-height=\"600\" data-sc-breakpoint=\"50em\" data-sc-load-immediate=\"5\" data-sc-content-positions=\"[1, 1250, 1, 1, 1, 1, 1, 1, 1]\" data-bind-scroll-on-start=\"true\">\n<div id=\"mntl-sc-block_1-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--finalverdict beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-finalverdict\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_1-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Key Takeaways<\/p>\n<div id=\"mntl-sc-block-callout-body_1-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Spironolactone is an oral medication primarily used off-label to treat stubborn hormonal acne in women. <\/li>\n<li>The medication works by reducing oil production and blocking hormones that can cause acne breakouts. <\/li>\n<li>Some side effects of Spironolactone include frequent urination, menstrual cramps, and potential fatigue.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_2-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Anybody who has experience with acne knows first-hand how frustrating it can be. Whether you only dealt with it for a short period in high school or have been battling it for decades, if you&#8217;re desperate enough to get rid of the bumps on your face and\/or skin, you&#8217;re open to trying almost anything to make it go away. There&#8217;s the standard exfoliating cleansers and tretinoin, but more intense breakouts sometimes call for Accutane or even Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_4-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We&#8217;re here to talk about the latter. Spironolactone is primarily known as an oral blood pressure medication. However, dermatologists sometimes recommend their clients use it off-label to treat hormonal acne\u2014and there&#8217;s a lot of science to back up their decision. In fact, one study found that 86% of patients saw their acne improve on spironolactone therapy, and most saw results after three to six months of use. Physicians say Spironolactone works by regulating oil production, blocking acne-causing androgen receptors, and reducing the intensity and lifespan of hormonal breakouts\u2014sounds good, right?\n<\/p>\n<p id=\"mntl-sc-block_6-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> We know that taking an oral medication of any type can be scary for some, and especially if it&#8217;s used off-label. So, we spoke to two dermatologists and a cosmetic chemist and asked them everything there is to know about about using Spironolactone to treat acne. <strong>Ahead, experts share everything you need to know about spironolactone.<\/strong><\/p>\n<div id=\"mntl-sc-block_8-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--meetourexpert beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-meetourexpert\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_2-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Meet the Experts<\/p>\n<div id=\"mntl-sc-block-callout-body_2-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<ul>\n<li>Justine Kluk, MD, is a board-certified dermatologist based in London.<\/li>\n<li>Susan Raffy is a California-based cosmetic chemist and the president of Susan Raffy Consulting.<\/li>\n<li>David Colbert, MD, is a dermatologist and the founder of the New York Dermatology Group.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<h2 id=\"mntl-sc-block_9-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Is Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_10-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is an oral form of medication that was initially developed to treat mild blood pressure irregularities and water retention. However, women with combination skin taking the drug for those aforementioned reasons soon found that one of the side effects was improved skin\u2014in particular, fewer spots and breakouts. Soon after this discovery (and plenty of clinical studies), dermatologists began prescribing Spironolactone off-label to treat difficult hormonal acne cases in women.\n<\/p>\n<div id=\"mntl-sc-block_12-0\" class=\"comp mntl-sc-block beauty-sc-block-callout--ffingredients beauty-sc-block-callout mntl-sc-block-callout mntl-block theme-ffingredients\" data-tracking-id=\"mntl-sc-block-callout\" data-tracking-container=\"true\">\n<p id=\"mntl-sc-block-callout-heading_3-0\" class=\"comp mntl-sc-block-callout-heading mntl-text-block\">Spironolactone<\/p>\n<div id=\"mntl-sc-block-callout-body_3-0\" class=\"comp mntl-sc-block-callout-body mntl-text-block\">\n<p><strong>Type of ingredient:<\/strong> Oral Medication<\/p>\n<p><strong>Main benefits: <\/strong>Regulates oil production, blocks androgen receptors, and reduces the length of hormonal breakouts.<\/p>\n<p><strong>Who should use it:<\/strong> In general, women with hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant. You must have a prescription to use Spironolactone.<\/p>\n<p><strong>How often should you use it?<\/strong> Consult a dermatologist.<\/p>\n<p><strong>Works well with: <\/strong>Generally, it works well with all topical treatments.<\/p>\n<p><strong>Don&#8217;t use with:<\/strong> Check with your physician for interactions with other medications.<\/p>\n<\/div>\n<\/div>\n<p id=\"mntl-sc-block_13-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Board-certified dermatologist Justine Kluk clarifies what is meant by &#8220;off-label&#8221; use: \u201cIt\u2019s not actually specifically licensed for treating acne in absence of a syndrome like PCOS, but dermatologists can prescribe the drug on an off-label basis for women who have a hormonal pattern to their spots and whose acne hasn\u2019t responded to first-line therapies such as prescription creams, antibiotics, and even Accutane.&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_15-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> How Does Spironolactone Work? <\/span><\/h2>\n<p id=\"mntl-sc-block_16-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The impact Spironolactone has on hormones is what give it those acne-clearing superpowers. It works by blocking the effect that androgens (hormones like testosterone) have on the body. Increased androgens can increase sebum production, which leads to clogged pores and acne flare-ups. So essentially, Spironolactone gets to the root of the cause by blocking the hormones at the core of the problem, which means the acne glands and hair follicles won\u2019t get overloaded, thus reducing the likelihood of developing pimples.\n<\/p>\n<p id=\"mntl-sc-block_18-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> And like most skincare products, topical or oral, you have to give Spironolactone some time to work. Kluk says it takes around three months to see results.\n<\/p>\n<h2 id=\"mntl-sc-block_20-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> What Do Studies Say About Spironolactone? <\/span><\/h2>\n<p id=\"mntl-sc-block_21-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> In one study, 85% of patients saw an improvement in their acne, and 55% were completely clear of acne after taking Spironolactone. Another study offered similar results, demonstrating that acne of all severity responded to Spironolactone.\n<\/p>\n<p id=\"mntl-sc-block_23-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> The good thing is that there\u2019s no time limit to how long you can take the drug, unlike the antibiotics that are often prescribed for acne. But Kluk says that many patients see improvement after just two &#8220;rounds&#8221; of treatment and find that they don&#8217;t have to continue taking the medication.\n<\/p>\n<figure id=\"mntl-sc-block_25-0\" class=\"comp mntl-sc-block beauty-sc-block-image mntl-sc-block-image figure-landscape figure-high-res\">\n<div class=\"figure-media\">\n<div class=\"img-placeholder\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"799\" alt=\"woman's spironolactone before and after photo\" class=\"lazyload mntl-image mntl-image universal-image__image\" id=\"mntl-sc-block-image_1-0\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/analyse.optim.biz\/wp-content\/uploads\/2026\/02\/spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6.webp\" width=\"1000\" height=\"799\" class=\"img--noscript mntl-image mntl-image universal-image__image\" alt=\"woman's spironolactone before and after photo\" title=\"spironolactonebeforeafter-df90a47d5f494021961b02bbcf5d34d6\"><\/div>\n<\/div><figcaption id=\"mntl-figure-caption_1-0\" class=\"comp mntl-figure-caption text-utility-100 figure-article-caption\"><span class=\"figure-article-caption-owner\"><\/p>\n<p>@maguaaa67 \/ Instagram<\/p>\n<p><\/span><\/figcaption><\/figure>\n<h2 id=\"mntl-sc-block_26-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Benefits of Spironolactone <\/span><\/h2>\n<ul id=\"mntl-sc-block_27-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Effective at Clearing Stubborn Hormonal Acne:<\/strong> While topical ingredients can certainly be effective for many people dealing with hormonal acne, Spironolactone can prevent blemishes from developing in the first place by blocking the androgens that stimulate sebum production. Many women dealing with stubborn hormonal acne that&#8217;s resistant to topical treatments find success in using Spironolactone.<\/li>\n<li><strong>Can Treat Hair Loss in Women:<\/strong> Due to its impact on hormone regulation, the drug has recently been prescribed for women experiencing hair loss. It hasn&#8217;t been found to have the same impact on men, however.<\/li>\n<li><strong>All-in-One Treatment: <\/strong>Because of the efficacy of Spironolactone, you may no longer need to use drying topicals to treat acne.<\/li>\n<\/ul>\n<h2 id=\"mntl-sc-block_29-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Who Can Take Spironolactone Safely? <\/span><\/h2>\n<p id=\"mntl-sc-block_30-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\"> Spironolactone is a prescription medication that should only be used under the direct supervision of a physician. Because the drug tampers with hormone levels and testosterone, it\u2019s recommended for use by women only. It also can\u2019t be prescribed for those who are trying to get pregnant, so bear this in mind if you\u2019re planning to conceive any time soon. Dr. Colbert also notes that in some cases, Spironolactone &#8220;may alter blood potassium levels, therefore, people with kidney disease should not take it,&#8221;\n<\/p>\n<h2 id=\"mntl-sc-block_32-0\" class=\"comp mntl-sc-block beauty-sc-block-heading mntl-sc-block-heading\"><span class=\"mntl-sc-block-heading__text text-title-300\"> Spironolactone Side Effects and Safety Considerations <\/span><\/h2>\n<p id=\"mntl-sc-block_33-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">The negative side effects associated with taking oral doses of Spironolactone include &#8220;electrolyte imbalance, breast tenderness, irregular periods, and increased urination,&#8221; says Raffy.\u00a0We elaborate, below.\n<\/p>\n<ol id=\"mntl-sc-block_35-0\" class=\"comp mntl-sc-block beauty-sc-block-html mntl-sc-block-html\">\n<li><strong>Frequent Urination: <\/strong>Spironolactone is a diuretic, so it removes excess fluid from the body via urination. Colbert recommends that patients stay well-hydrated and carry a water bottle while taking Spironolactone to minimize dehydration from the diuretic effect.<\/li>\n<li><strong>Increased Menstruation Cramps: <\/strong>Spironolactone can alter the body&#8217;s electrolyte balance (think potassium, magnesium, and calcium)\u2014thereby leading to low sodium. An imbalance of electrolytes can lead to muscle cramps, which can be particularly problematic during menstruation, when cramps are already an issue. If experiencing any form of cramps or dizziness, speak to a doctor.<\/li>\n<li><strong>Hormonal Acne: <\/strong>While the medication helps with breakouts, it also alters the hormonal balance. As many know from experiencing hormonal breakouts, acne can result.<\/li>\n<li><strong>Fatigue: <\/strong>Spironolactone blocks certain hormones and lowers blood pressure\u2014both of which can cause fatigue. If you feel suddenly tired (and that&#8217;s unusual) it&#8217;s best to seek the advice of an expert before continuing the medication.<\/li>\n<\/ol>\n<div id=\"mntl-sc-block_37-0\" class=\"comp mntl-sc-block beauty-sc-block-faq--expanded beauty-sc-block-faq mntl-sc-block-faq mntl-block is-expanded\">\n<div id=\"mntl-sc-block-faq__title_1-0\" class=\"comp mntl-sc-block-faq__title mntl-text-block\">FAQ<\/div>\n<ul id=\"mntl-sc-block-faq__content_1-0\" class=\"comp mntl-sc-block-faq__content mntl-accordion \" data-tracking-container=\"true\">\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"1\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_1-0-section-0\"><span class=\"accordion__title\">Who can and can&#8217;t use Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_1-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>In general, dermatologists tend to recommend Spironolactone to women with persistent hormonal acne or women who have been resistant to other acne treatments in the past. It is not recommended for men or for women who are looking to become pregnant.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"2\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_2-0-section-1\"><span class=\"accordion__title\">Can Spironolactone cause weight gain?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_2-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>While some individuals have reported experiencing weight gain while taking Spironolactone, there is little evidence to support this. Weight gain is not considered a formal side effect of Spironolactone and it is not listed as a side effect on the packaging of the medication.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"3\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_3-0-section-2\"><span class=\"accordion__title\">Are there alternatives to Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_3-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>If you&#8217;re dealing with hormonal acne, talk to your dermatologist. They may recommend a specific birth control or prescription topical before resorting to Spironolactone.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"4\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_4-0-section-3\"><span class=\"accordion__title\">How quickly does Spironolactone work for acne?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_4-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>The American Academy of Dermatology notes that, on average, women notice improvement in their acne after taking Spironolactone for two to three months.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<li class=\"accordion__item js-accordion-item is-active\" data-ordinal=\"5\">\n<div class=\"accordion__header js-accordion-trigger\" id=\"mntl-accordion__item_5-0-section-4\"><span class=\"accordion__title\">Why is my face getting worse on Spironolactone?<\/span><\/div>\n<div class=\"accordion__body\">\n<div id=\"mntl-accordion__content_5-0\" class=\"comp mntl-accordion__content\">\n<div class=\"faq-accordion__item-answer\">\n<p>Since Spironolactone blocks certain hormones, the medication can cause acne to get worse at times. If it doesn&#8217;t improve with time, it&#8217;s best to seek expert input.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<p> Source URL: https:\/\/www.byrdie.com\/spironolactone-for-acne-11895917<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Read This If You&#8217;re Considering Spironolactone For Acne Here&#8217;s what dermatologists have to say. By Becci Vallis Becci Vallis Becci is a contributing beauty editor at Cosmopolitan. She also contributes regularly to Byrdie, Stylist, Fabulous, and Brides. Byrdie&#8217;s Editorial Guidelines Published on January 30, 2026 07:42AM Reviewed by Karen Kagha, MD Reviewed by Karen Kagha, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1721424,"comment_status":"open","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2],"tags":[83,226],"class_list":["post-1721423","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-politics","tag-byrdie-com","tag-crawlmanager"],"_links":{"self":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/1721423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1721423"}],"version-history":[{"count":0,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/posts\/1721423\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=\/wp\/v2\/media\/1721424"}],"wp:attachment":[{"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1721423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1721423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/analyse.optim.biz\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1721423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}